TARBP1

Last updated
TARBP1
Protein TARBP1 PDB 2ha8.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TARBP1 , TRM3, TRP-185, TRP185, TAR (HIV-1) RNA binding protein 1, TRMT3
External IDs OMIM: 605052; MGI: 4936930; HomoloGene: 38082; GeneCards: TARBP1; OMA:TARBP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005646

NM_001159907

RefSeq (protein)

NP_005637

NP_001153379

Location (UCSC) Chr 1: 234.39 – 234.48 Mb Chr 8: 127.15 – 127.2 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable methyltransferase TARBP1 is an enzyme that in humans is encoded by the TARBP1 gene. [5] [6]

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined. [6]

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000059588 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090290 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wu F, Garcia J, Sigman D, Gaynor R (Dec 1991). "tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185". Genes Dev. 5 (11): 2128–40. doi: 10.1101/gad.5.11.2128 . PMID   1936997.
  6. 1 2 "Entrez Gene: TARBP1 Tar (HIV-1) RNA binding protein 1".

Further reading