TBC1D10A

TBC1D10A
Identifiers
Aliases	TBC1D10A , EPI64, TBC1D10, dJ130H16.1, dJ130H16.2, TBC1 domain family member 10A
External IDs	OMIM: 610020; MGI: 2144164; HomoloGene: 32762; GeneCards: TBC1D10A; OMA:TBC1D10A - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q12.2 Start 30,291,990 bp [1] End 30,326,947 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 A1 Start 4,136,789 bp [2] End 4,165,505 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nasal epithelium skin of arm skin of leg mucosa of esophagus skin of abdomen granulocyte gingival epithelium mucosa of transverse colon ascending aorta spleen Top expressed in lip right kidney gastrula yolk sac molar spermatocyte esophagus proximal tubule corneal stroma spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding protein binding guanyl-nucleotide exchange factor activity GTPase activator activity cadherin binding Cellular component microvillus plasma membrane cell projection extracellular exosome endomembrane system cytosol intracellular anatomical structure Biological process regulation of cilium assembly activation of cysteine-type endopeptidase activity retrograde transport, endosome to Golgi positive regulation of proteolysis activation of GTPase activity regulation of vesicle fusion intracellular protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83874 103724 Ensembl ENSG00000099992 ENSMUSG00000034412 UniProt Q9BXI6 P58802 RefSeq (mRNA) NM_031937 NM_001204240 NM_134023 RefSeq (protein) NP_001191169 NP_114143 NP_001191169.1 NP_114143.1 NP_598784 Location (UCSC) Chr 22: 30.29 – 30.33 Mb Chr 11: 4.14 – 4.17 Mb PubMed search [3] [4]
Wikidata
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TBC1 domain family member 10A is a protein that in humans is encoded by the TBC1D10A gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000099992 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034412 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Reczek D, Bretscher A (Apr 2001). "Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP". J Cell Biol. 153 (1): 191–206. doi:10.1083/jcb.153.1.191. PMC   2185518 . PMID   11285285.
6. "Entrez Gene: TBC1D10A TBC1 domain family, member 10A".

Further reading

• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10) R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID   15790807. S2CID   13047538.
• Kapranov P, Drenkow J, Cheng J, et al. (2005). "Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays". Genome Res. 15 (7): 987–97. doi:10.1101/gr.3455305. PMC   1172043 . PMID   15998911.
• Itoh T, Fukuda M (2006). "Identification of EPI64 as a GTPase-activating protein specific for Rab27A". J. Biol. Chem. 281 (42): 31823–31. doi: 10.1074/jbc.M603808200 . PMID   16923811.
• Hanono A, Garbett D, Reczek D, et al. (2007). "EPI64 regulates microvillar subdomains and structure". J. Cell Biol. 175 (5): 803–13. doi:10.1083/jcb.200604046. PMC   2064679 . PMID   17145964.