TBC1D15

TBC1D15
Identifiers
Aliases	TBC1D15 , RAB7-GAP, TBC1 domain family member 15
External IDs	OMIM: 612662 MGI: 1913937 HomoloGene: 11249 GeneCards: TBC1D15
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q21.1 Start 71,839,707 bp [1] End 71,927,248 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 D2 Start 115,197,872 bp [2] End 115,251,467 bp [2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity Cellular component • cytoplasm • extracellular region • endomembrane system • intracellular anatomical structure Biological process • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • regulation of cilium assembly • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity • intracellular protein transport • regulation of vesicle fusion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64786	66687
Ensembl	ENSG00000121749	ENSMUSG00000020130
UniProt	Q8TC07	Q9CXF4
RefSeq (mRNA)	NM_001146213 NM_001146214 NM_022771	NM_025706
RefSeq (protein)	NP_001139685 NP_001139686 NP_073608	NP_079982
Location (UCSC)	Chr 12: 71.84 – 71.93 Mb	Chr 10: 115.2 – 115.25 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

TBC1 domain family member 15 is a protein that in humans is encoded by the TBC1D15 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000121749 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020130 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
6. "Entrez Gene: TBC1D15 TBC1 domain family, member 15".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Zhang XM, Walsh B, Mitchell CA, Rowe T (2005). "TBC domain family, member 15 is a novel mammalian Rab GTPase-activating protein with substrate preference for Rab7". Biochem. Biophys. Res. Commun. 335 (1): 154–61. doi:10.1016/j.bbrc.2005.07.070. PMID   16055087.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.