TBCA

TBCA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H7C
Identifiers
Aliases	TBCA , tubulin folding cofactor A
External IDs	OMIM: 610058 MGI: 107549 HomoloGene: 3388 GeneCards: TBCA
Gene location (Human)
Chr.	Chromosome 5 (human)
End	77,868,780 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	94,842,922 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• chaperone binding ; • GO:0001948 protein binding ; • beta-tubulin binding ; • RNA binding ;
Cellular component	• cytoplasm ; • microtubule cytoskeleton ; • nucleolus ; • microtubule ; • cytoskeleton ; • extracellular exosome ;
Biological process	• post-chaperonin tubulin folding pathway ; • tubulin complex assembly ; • protein folding ;
	Sources:Amigo / QuickGO
Orthologs
	6902
	21371
	ENSG00000171530
	ENSMUSG00000042043
	O75347
	P48428
	NM_004607 ; NM_001297738 ; NM_001297740
	NM_009321
	NP_001284667 ; NP_001284669 ; NP_004598
	NP_033347
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 22, 2021

Tubulin-specific chaperone A is a protein that in humans is encoded by the TBCA gene.^[5]^[6]^[7]

The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A.^[7]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171530 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042043 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi: 10.1073/pnas.95.14.8175 . PMC 20949 . PMID 9653160.
↑ Tian G, Huang Y, Rommelaere H, Vandekerckhove J, Ampe C, Cowan NJ (Sep 1996). "Pathway leading to correctly folded beta-tubulin". Cell. 86 (2): 287–96. doi: 10.1016/S0092-8674(00)80100-2 . PMID 8706133.
1 2 "Entrez Gene: TBCA tubulin folding cofactor A".

Lewis SA, Tian G, Vainberg IE, Cowan NJ (1996). "Chaperonin-mediated folding of actin and tubulin". J. Cell Biol. 132 (1–2): 1–4. doi:10.1083/jcb.132.1.1. PMC 2120700 . PMID 8567715.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934 . PMID 11042152.
Guasch A, Aloria K, Pérez R, et al. (2002). "Three-dimensional structure of human tubulin chaperone cofactor A". J. Mol. Biol. 318 (4): 1139–49. doi:10.1016/S0022-2836(02)00185-7. hdl:10261/109021. PMID 12054808.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Nolasco S, Bellido J, Gonçalves J, et al. (2005). "Tubulin cofactor A gene silencing in mammalian cells induces changes in microtubule cytoskeleton, cell cycle arrest and cell death" (PDF). FEBS Lett. 579 (17): 3515–24. doi: 10.1016/j.febslet.2005.05.022 . hdl:10400.21/3045. PMID 15963512.
Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171530 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042043 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9653160-5] Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi: 10.1073/pnas.95.14.8175 . PMC 20949 . PMID 9653160.

[pmid8706133-6] Tian G, Huang Y, Rommelaere H, Vandekerckhove J, Ampe C, Cowan NJ (Sep 1996). "Pathway leading to correctly folded beta-tubulin". Cell. 86 (2): 287–96. doi: 10.1016/S0092-8674(00)80100-2 . PMID 8706133.

[entrez-7] 1 2 "Entrez Gene: TBCA tubulin folding cofactor A".

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TBCA

Related Research Articles

References

Further reading