TC-G 1005

TC-G 1005

Identifiers
IUPAC name (4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[4-(2,5-dimethylphenoxy)pyridin-3-yl]methanone
CAS Number	1415407-60-1
PubChem CID	71450251
ChemSpider	28663072
ChEMBL	ChEMBL2181226
Chemical and physical data
Formula	C25H25N3O2
Molar mass	399.494 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=CC(=C(C=C1)C)OC2=C(C=NC=C2)C(=O)N3CCN(C4=CC=CC=C43)C5CC5
InChI InChI=1S/C25H25N3O2/c1-17-7-8-18(2)24(15-17)30-23-11-12-26-16-20(23)25(29)28-14-13-27(19-9-10-19)21-5-3-4-6-22(21)28/h3-8,11-12,15-16,19H,9-10,13-14H2,1-2H3 Key:JQULIQJSYPZQMA-UHFFFAOYSA-N

TC-G 1005 is an experimental drug which acts as a potent and selective agonist for the G protein-coupled bile acid receptor (GPBAR1/TGR5). It is used for studying the function of this receptor, and has been found to induce secretion of glucagon-like peptide-1 and reduce blood glucose levels. ^{[1] [2]}

References

1. Duan H, Ning M, Chen X, Zou Q, Zhang L, Feng Y, et al. (December 2012). "Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists". Journal of Medicinal Chemistry. 55 (23): 10475–10489. doi:10.1021/jm301071h. PMID   23148522.
2. Urso A, D'Ovidio F, Xu D, Emala CW, Bunnett NW, Perez-Zoghbi JF (February 2020). "Bile acids inhibit cholinergic constriction in proximal and peripheral airways from humans and rodents". American Journal of Physiology. Lung Cellular and Molecular Physiology. 318 (2): L264 –L275. doi:10.1152/ajplung.00242.2019. PMC   7474253 . PMID   31800261.