TCEA1

TCEA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TFI, 3NDQ, 5IY7, 5IYA, 5IY6, 5IYB, 5IY8, 5IYC
Identifiers
Aliases	TCEA1 , GTF2S, SII, TCEA, TF2S, TFIIS, transcription elongation factor A1
External IDs	OMIM: 601425 MGI: 1196624 HomoloGene: 55984 GeneCards: TCEA1
Gene location (Human)
Chr.	Chromosome 8 (human)
End	54,022,456 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	4,968,132 bp
RNA expression pattern
	Top expressed in
	spongy bone; ; Achilles tendon; ; optic nerve; ; caput epididymis; ; corpus epididymis; ; parotid gland; ; lactiferous duct; ; bronchial epithelial cell; ; saphenous vein; ; vulva;
	Top expressed in
	secondary oocyte; ; medial ganglionic eminence; ; parotid gland; ; lacrimal gland; ; hand; ; calvaria; ; somite; ; abdominal wall; ; seminal vesicula; ; vas deferens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding ; zinc ion binding ; protein binding ; metal ion binding ; nucleic acid binding ;
Cellular component	nucleolus ; nucleus ; nucleoplasm ; transcription factor TFIID complex ;
Biological process	transcription elongation from RNA polymerase II promoter ; transcription-coupled nucleotide-excision repair ; regulation of transcription, DNA-templated ; transcription by RNA polymerase II ; transcription, DNA-templated ; positive regulation of exoribonuclease activity ; positive regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	6917
	21399
	ENSG00000187735
	ENSMUSG00000033813
	P23193
	P10711
	NM_006756 ; NM_201437
	NM_001159750 ; NM_001159751 ; NM_011541
	NP_006747 ; NP_958845
	NP_001153222 ; NP_001153223 ; NP_035671
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 05, 2024

Transcription elongation factor A protein 1 is a protein that in humans is encoded by the TCEA1 gene.^[5]^[6]^[7]

In other organisms, this gene is better known as transcription elongation factor II S (TFIIS). It mainly helps to resolve backtracked elongation complexes by inducing a cut in the RNAP active site, so reaction becomes possible again. It is also found in the eukaryotic transcription preinitiation complex.^[8] A homolog in archaea performs the same main task, while bacteria use the non-homologous Gre.^[9]

Interactions

TCEA1 has been shown to interact with GTF2H1 ^[10]^[11] and POLR2A.^[10]^[11]^[12]

Related Research Articles

<span class="mw-page-title-main">RNA polymerase II</span> Protein complex that transcribes DNA

RNA polymerase II is a multiprotein complex that transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA (snRNA) and microRNA. It is one of the three RNAP enzymes found in the nucleus of eukaryotic cells. A 550 kDa complex of 12 subunits, RNAP II is the most studied type of RNA polymerase. A wide range of transcription factors are required for it to bind to upstream gene promoters and begin transcription.

DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that is encoded by the POLR2A gene in humans.

Transcription elongation factor SPT5 is a protein that in humans is encoded by the SUPT5H gene.

Elongin C is a protein that in humans is encoded by the ELOC gene.

Elongin B is a protein that in humans is encoded by the ELOB gene.

Elongation factor 1-alpha 1 (eEF1a1) is a translation elongation protein, expressed across eukaryotes. In humans, it is encoded by the EEF1A1 gene.

Negative elongation factor E is a protein that in humans is encoded by the RDBP gene.

Mediator of RNA polymerase II transcription subunit 21 is an enzyme that in humans is encoded by the MED21 gene.

Elongin A is a protein that in humans is encoded by the ELOA gene.

Transcription elongation factor A protein 2 is a protein that in humans is encoded by the TCEA2 gene.

TFIIA-alpha and beta-like factor is a protein that in humans is encoded by the GTF2A1L gene.

General transcription factor IIH subunit 1 is a protein that in humans is encoded by the GTF2H1 gene.

snRNA-activating protein complex subunit 2 is a protein that in humans is encoded by the SNAPC2 gene.

General transcription factor IIF subunit 1 is a protein that in humans is encoded by the GTF2F1 gene.

DNA-directed RNA polymerase, mitochondrial is an enzyme that in humans is encoded by the POLRMT gene.

Transcription termination factor 2 is a protein that in humans is encoded by the TTF2 gene.

Mediator of RNA polymerase II transcription subunit 26 is an enzyme that in humans is encoded by the MED26 gene. It forms part of the Mediator complex.

DSIF is a protein complex that can either negatively or positively affect transcription by RNA polymerase II. It can interact with the negative elongation factor (NELF) to promote the stalling of Pol II at some genes, which is called promoter proximal pausing. The pause occurs soon after initiation, once 20-60 nucleotides have been transcribed. This stalling is relieved by positive transcription elongation factor b (P-TEFb) and Pol II enters productive elongation to resume synthesis till finish. In humans, DSIF is composed of hSPT4 and hSPT5. hSPT5 has a direct role in mRNA capping which occurs while the elongation is paused.

General transcription factor IIE subunit 2 (GTF2E2), also known as transcription initiation factor IIE subunit beta (TFIIE-beta), is a protein that in humans is encoded by the GTF2E2 gene.

General transcription factor IIE subunit 1 (GTF2E1), also known as transcription initiation factor IIE subunit alpha (TFIIE-alpha), is a protein that in humans is encoded by the GTF2E1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000187735 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033813 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ DiMarco SP, Glover TW, Miller DE, Reines D, Warren ST (August 1996). "Transcription elongation factor SII (TCEA) maps to human chromosome 3p22 --> p21.3". Genomics. 36 (1): 185–8. doi:10.1006/geno.1996.0443. PMID 8812434.
↑ Park H, Baek K, Jeon C, Agarwal K, Yoo O (February 1994). "Characterization of the gene encoding the human transcriptional elongation factor TFIIS". Gene. 139 (2): 263–7. doi:10.1016/0378-1119(94)90767-6. PMID 8112616.
↑ "Entrez Gene: TCEA1 transcription elongation factor A (SII), 1".
↑ Kim B, Nesvizhskii AI, Rani PG, Hahn S, Aebersold R, Ranish JA (October 2007). "The transcription elongation factor TFIIS is a component of RNA polymerase II preinitiation complexes". Proceedings of the National Academy of Sciences of the United States of America. 104 (41): 16068–73. Bibcode:2007PNAS..10416068K. doi: 10.1073/pnas.0704573104 . PMC 2042163 . PMID 17913884.
↑ Robinson NP, Fouqueau T, Blombach F, Cackett G, Carty AE, Matelska DM, Ofer S, Pilotto S, Phung DK, Werner F (14 December 2018). "The cutting edge of archaeal transcription". Emerging Topics in Life Sciences. 2 (4): 517–533. doi: 10.1042/ETLS20180014 . PMC 7289017 . PMID 33525828.
1 2 Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, et al. (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". The Journal of Biological Chemistry. 273 (42): 27593–601. doi: 10.1074/jbc.273.42.27593 . PMID 9765293.
1 2 Pan G, Aso T, Greenblatt J (September 1997). "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators". The Journal of Biological Chemistry. 272 (39): 24563–71. doi: 10.1074/jbc.272.39.24563 . PMID 9305922.
↑ Kettenberger H, Armache KJ, Cramer P (August 2003). "Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage". Cell. 114 (3): 347–57. doi:10.1016/S0092-8674(03)00598-1. hdl: 11858/00-001M-0000-0015-8647-8 . PMID 12914699. S2CID 17184533.

Chen HC, England L, Kane CM (July 1992). "Characterization of a HeLa cDNA clone encoding the human SII protein, an elongation factor for RNA polymerase II". Gene. 116 (2): 253–8. doi:10.1016/0378-1119(92)90522-Q. PMID 1378807.
Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen CA, Roeder RG (April 1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes & Development. 6 (4): 655–66. doi: 10.1101/gad.6.4.655 . PMID 1559613.
Yoo OJ, Yoon HS, Baek KH, Jeon CJ, Miyamoto K, Ueno A, Agarwal K (March 1991). "Cloning, expression and characterization of the human transcription elongation factor, TFIIS". Nucleic Acids Research. 19 (5): 1073–9. doi:10.1093/nar/19.5.1073. PMC 333783 . PMID 1708494.
Reines D, Chamberlin MJ, Kane CM (June 1989). "Transcription elongation factor SII (TFIIS) enables RNA polymerase II to elongate through a block to transcription in a human gene in vitro". The Journal of Biological Chemistry. 264 (18): 10799–809. doi: 10.1016/S0021-9258(18)81692-1 . PMID 2471707.
Qian X, Jeon C, Yoon H, Agarwal K, Weiss MA (September 1993). "Structure of a new nucleic-acid-binding motif in eukaryotic transcriptional elongation factor TFIIS". Nature. 365 (6443): 277–9. Bibcode:1993Natur.365..277Q. doi:10.1038/365277a0. hdl: 10356/94482 . PMID 7626141. S2CID 4367997.
Yeh CH, Shatkin AJ (June 1994). "A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII". Gene. 143 (2): 285–7. doi:10.1016/0378-1119(94)90112-0. PMID 8206389.
Umehara T, Kida S, Yamamoto T, Horikoshi M (December 1995). "Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II". Gene. 167 (1–2): 297–302. doi:10.1016/0378-1119(95)00634-6. PMID 8566795.
Powell W, Bartholomew B, Reines D (September 1996). "Elongation factor SII contacts the 3'-end of RNA in the RNA polymerase II elongation complex". The Journal of Biological Chemistry. 271 (37): 22301–4. doi: 10.1074/jbc.271.37.22301 . PMC 3371613 . PMID 8798387.
Pan G, Aso T, Greenblatt J (September 1997). "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators". The Journal of Biological Chemistry. 272 (39): 24563–71. doi: 10.1074/jbc.272.39.24563 . PMID 9305922.
Li XY, Green MR (October 1998). "The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor". Genes & Development. 12 (19): 2992–6. doi:10.1101/gad.12.19.2992. PMC 317190 . PMID 9765201.
Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, et al. (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". The Journal of Biological Chemistry. 273 (42): 27593–601. doi: 10.1074/jbc.273.42.27593 . PMID 9765293.
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, et al. (October 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163 . PMID 11591653.
Saso K, Ito T, Natori S, Sekimizu K (April 2003). "Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II". Journal of Biochemistry. 133 (4): 493–500. doi:10.1093/jb/mvg065. PMID 12761297.
Imabayashi H, Mori T, Gojo S, Kiyono T, Sugiyama T, Irie R, et al. (August 2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Experimental Cell Research. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
Kettenberger H, Armache KJ, Cramer P (August 2003). "Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage". Cell. 114 (3): 347–57. doi:10.1016/S0092-8674(03)00598-1. hdl: 11858/00-001M-0000-0015-8647-8 . PMID 12914699. S2CID 17184533.
Tamura K, Miyata K, Sugahara K, Onishi S, Shuin T, Aso T (September 2003). "Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain". Biochemical and Biophysical Research Communications. 309 (1): 189–95. doi:10.1016/S0006-291X(03)01556-0. PMID 12943681.
Zhang C, Yan H, Burton ZF (December 2003). "Combinatorial control of human RNA polymerase II (RNAP II) pausing and transcript cleavage by transcription factor IIF, hepatitis delta antigen, and stimulatory factor II". The Journal of Biological Chemistry. 278 (50): 50101–11. doi: 10.1074/jbc.M307590200 . PMID 14506279.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000187735 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033813 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8812434-5] DiMarco SP, Glover TW, Miller DE, Reines D, Warren ST (August 1996). "Transcription elongation factor SII (TCEA) maps to human chromosome 3p22 --> p21.3". Genomics. 36 (1): 185–8. doi:10.1006/geno.1996.0443. PMID 8812434.

[pmid8112616-6] Park H, Baek K, Jeon C, Agarwal K, Yoo O (February 1994). "Characterization of the gene encoding the human transcriptional elongation factor TFIIS". Gene. 139 (2): 263–7. doi:10.1016/0378-1119(94)90767-6. PMID 8112616.

[entrez-7] "Entrez Gene: TCEA1 transcription elongation factor A (SII), 1".

[8] Kim B, Nesvizhskii AI, Rani PG, Hahn S, Aebersold R, Ranish JA (October 2007). "The transcription elongation factor TFIIS is a component of RNA polymerase II preinitiation complexes". Proceedings of the National Academy of Sciences of the United States of America. 104 (41): 16068–73. Bibcode:2007PNAS..10416068K. doi: 10.1073/pnas.0704573104 . PMC 2042163 . PMID 17913884.

[edge-9] Robinson NP, Fouqueau T, Blombach F, Cackett G, Carty AE, Matelska DM, Ofer S, Pilotto S, Phung DK, Werner F (14 December 2018). "The cutting edge of archaeal transcription". Emerging Topics in Life Sciences. 2 (4): 517–533. doi: 10.1042/ETLS20180014 . PMC 7289017 . PMID 33525828.

[pmid9765293-10] 1 2 Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, et al. (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". The Journal of Biological Chemistry. 273 (42): 27593–601. doi: 10.1074/jbc.273.42.27593 . PMID 9765293.

[pmid9305922-11] 1 2 Pan G, Aso T, Greenblatt J (September 1997). "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators". The Journal of Biological Chemistry. 272 (39): 24563–71. doi: 10.1074/jbc.272.39.24563 . PMID 9305922.

[pmid12914699-12] Kettenberger H, Armache KJ, Cramer P (August 2003). "Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage". Cell. 114 (3): 347–57. doi:10.1016/S0092-8674(03)00598-1. hdl: 11858/00-001M-0000-0015-8647-8 . PMID 12914699. S2CID 17184533.

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TCEA1

Contents

Interactions

Related Research Articles

References

Further reading