TCHP | |||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | TCHP , TpMs, trichoplein keratin filament binding | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 612654 MGI: 1925082 HomoloGene: 12686 GeneCards: TCHP | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
|
Trichoplein keratin filament-binding protein is a protein that in humans is encoded by the TCHP gene. [5] [6]
Lamina-associated polypeptide 2 (LAP2), isoforms beta/gamma is a protein that in humans is encoded by the TMPO gene. LAP2 is an inner nuclear membrane (INM) protein.
Keratin 5, also known as KRT5, K5, or CK5, is a protein that is encoded in humans by the KRT5 gene. It dimerizes with keratin 14 and forms the intermediate filaments (IF) that make up the cytoskeleton of basal epithelial cells. This protein is involved in several diseases including epidermolysis bullosa simplex and breast and lung cancers.
Periplakin is a protein that in humans is encoded by the PPL gene.
Thyroid receptor-interacting protein 6 is a protein that in humans is encoded by the TRIP6 gene.
S100 calcium-binding protein A13 (S100A13) is a protein that in humans is encoded by the S100A13 gene.
Transcriptional regulator Kaiso is a protein that in humans is encoded by the ZBTB33 gene. This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2, which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
Plakophilin-1 is a protein that in humans is encoded by the PKP1 gene.
A-kinase anchor protein 8-like is a protein that in humans is encoded by the AKAP8L gene.
FH1/FH2 domain-containing protein 1 is a protein that in humans is encoded by the FHOD1 gene.
Envoplakin is a protein that in humans is encoded by the EVPL gene.
Translin-associated protein X is a protein that in humans is encoded by the TSNAX gene.
BFSP1 is a gene that encodes the protein filensin in humans.
Synaptotagmin-9 is a protein that in humans is encoded by the SYT9 gene.
Ligatin, otherwise known as eIF2D, is a protein that in humans is encoded by the LGTN gene. This protein is not a component of the heterotrimeric eIF2 complex, but instead functions in different pathways of eukaryotic translation.
Peroxisome assembly protein 26 is a protein that in humans is encoded by the PEX26 gene.
Keratin, type II cytoskeletal 78 is a protein that in humans is encoded by the KRT78 gene.
Dynein, light chain, Tctex-type 3, also known as DYNLT3, is a protein which in humans is encoded by the DYNLT3 gene.
Ras-related GTP-binding protein A is a protein that in humans is encoded by the RRAGA gene.
Keratin, type I cytoskeletal 23 is a protein that in humans is encoded by the KRT23 gene.
Keratin 79 also known as KRT79 is a protein which humans is encoded by the KRT79 gene.