TEGT

TMBIM6
Identifiers
Aliases	TMBIM6 , BAXI1, BI-1, TEGT, transmembrane BAX inhibitor motif containing 6
External IDs	OMIM: 600748 MGI: 99682 HomoloGene: 2419 GeneCards: TMBIM6
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.12 Start 49,707,725 bp [1] End 49,764,934 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15 F1|15 56.13 cM Start 99,290,763 bp [2] End 99,307,930 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans renal medulla parotid gland gallbladder rectum right lobe of liver bronchial epithelial cell kidney Left adrenal gland duodenum Top expressed in lacrimal gland kidney submandibular gland olfactory epithelium Epithelium of stomach parotid gland jejunum intestinal villus renal corpuscle duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function endoribonuclease inhibitor activity protein binding enzyme binding ubiquitin protein ligase binding Cellular component cytoplasm integral component of membrane endoplasmic reticulum membrane membrane mitochondrial membrane integral component of plasma membrane endoplasmic reticulum nucleus Biological process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of endoribonuclease activity negative regulation of apoptotic signaling pathway negative regulation of apoptotic process negative regulation of protein binding endoplasmic reticulum calcium ion homeostasis response to endoplasmic reticulum stress autophagy response to unfolded protein intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress response to L-glutamate negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway apoptotic process negative regulation of calcium ion transport into cytosol negative regulation of RNA splicing cellular response to unfolded protein Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7009 110213 Ensembl ENSG00000139644 ENSMUSG00000023010 UniProt P55061 Q9D2C7 RefSeq (mRNA) NM_001098576 NM_003217 NM_001171034 NM_001171035 NM_001171036 NM_026669 RefSeq (protein) NP_001092046 NP_003208 NP_001164505 NP_001164506 NP_001164507 NP_080945 Location (UCSC) Chr 12: 49.71 – 49.76 Mb Chr 15: 99.29 – 99.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Bax inhibitor 1 is a protein that in humans is encoded by the TMBIM6 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000139644 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023010 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Walter L, Marynen P, Szpirer J, Levan G, Gunther E (Feb 1996). "Identification of a novel conserved human gene, TEGT". Genomics. 28 (2): 301–4. doi:10.1006/geno.1995.1145. PMID   8530040.
6. Xu Q, Reed JC (Jul 1998). "Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast". Mol Cell. 1 (3): 337–46. doi: 10.1016/S1097-2765(00)80034-9 . PMID   9660918.
7. "Entrez Gene: TEGT testis enhanced gene transcript (BAX inhibitor 1)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID   8889549.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Cowling RT, Birnboim HC (1999). "Preliminary characterization of the protein encoded by human testis-enhanced gene transcript (TEGT)". Mol. Membr. Biol. 15 (4): 177–87. doi:10.3109/09687689709044319. PMID   10087504.
• Jean JC, Oakes SM, Joyce-Brady M (1999). "The Bax inhibitor-1 gene is differentially regulated in adult testis and developing lung by two alternative TATA-less promoters". Genomics. 57 (2): 201–8. doi: 10.1006/geno.1999.5761 . PMID   10198159.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Grzmil M, Thelen P, Hemmerlein B, et al. (2003). "Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells". Am. J. Pathol. 163 (2): 543–52. doi:10.1016/S0002-9440(10)63682-6. PMC   1868227 . PMID   12875974.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Tanaka R, Ishiyama T, Uchihara T, et al. (2006). "Expression of the Bax inhibitor-1 gene in pulmonary adenocarcinoma". Cancer. 106 (3): 648–53. doi:10.1002/cncr.21639. PMID   16353209. S2CID   1629852.
• Lee GH, Kim HK, Chae SW, et al. (2007). "Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-1 expression". J. Biol. Chem. 282 (30): 21618–28. doi: 10.1074/jbc.M700053200 . PMID   17526500.