TFPI2

TFPI2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZR0
Identifiers
Aliases	TFPI2 , PP5, REF1, TFPI-2, tissue factor pathway inhibitor 2
External IDs	OMIM: 600033; MGI: 108543; HomoloGene: 38194; GeneCards: TFPI2; OMA:TFPI2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q21.3 Start 93,885,396 bp [1] End 93,890,753 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 A1|6 1.81 cM Start 3,962,595 bp [2] End 3,988,919 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium parietal pleura islet of Langerhans cartilage tissue retinal pigment epithelium germinal epithelium pericardium placenta beta cell gonad Top expressed in decidua left lobe of liver endothelial cell of lymphatic vessel right kidney gastrula human kidney atrioventricular valve embryo migratory enteric neural crest cell yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity extracellular matrix structural constituent serine-type endopeptidase inhibitor activity Cellular component extracellular region extracellular matrix extracellular space Biological process hemostasis negative regulation of peptidase activity blood coagulation negative regulation of endopeptidase activity cellular response to fluid shear stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7980 21789 Ensembl ENSG00000105825 ENSMUSG00000029664 UniProt P48307 O35536 RefSeq (mRNA) NM_006528 NM_001271003 NM_001271004 NM_009364 NM_001381907 NM_001381908 RefSeq (protein) NP_001257932 NP_001257933 NP_006519 NP_033390 NP_001368836 NP_001368837 Location (UCSC) Chr 7: 93.89 – 93.89 Mb Chr 6: 3.96 – 3.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tissue factor pathway inhibitor 2 is a protein that in humans is encoded by the TFPI2 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000105825 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029664 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Miyagi Y, Koshikawa N, Yasumitsu H, Miyagi E, Hirahara F, Aoki I, Misugi K, Umeda M, Miyazaki K (Apr 1995). "cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: identification as placental protein 5 and tissue factor pathway inhibitor-2". J Biochem. 116 (5): 939–42. doi:10.1093/oxfordjournals.jbchem.a124648. PMID   7896752.
6. Miyagi Y, Yasumitsu H, Mizushima H, Koshikawa N, Matsuda Y, Itoh H, Hori TA, Aoki I, Misugi K, Miyazaki K (Jan 1997). "Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the gene to chromosome 6". DNA Cell Biol. 15 (11): 947–54. doi:10.1089/dna.1996.15.947. PMID   8945635.
7. "Entrez Gene: TFPI2 tissue factor pathway inhibitor 2".

Further reading

• Bützow R, Huhtala ML, Bohn H, et al. (1988). "Purification and characterization of placental protein 5". Biochem. Biophys. Res. Commun. 150 (1): 483–90. doi:10.1016/0006-291X(88)90546-3. PMID   3276312.
• Takayama M, Soma H, Saito T, et al. (1983). "Circulating levels of placental protein 5 in normal and abnormal pregnancies". Gynecol. Obstet. Invest. 16 (1): 13–26. doi:10.1159/000299207. PMID   6884838.
• Sprecher CA, Kisiel W, Mathewes S, Foster DC (1994). "Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3353–7. Bibcode:1994PNAS...91.3353S. doi: 10.1073/pnas.91.8.3353 . PMC   43575 . PMID   8159751.
• Petersen LC, Sprecher CA, Foster DC, et al. (1996). "Inhibitory properties of a novel human Kunitz-type protease inhibitor homologous to tissue factor pathway inhibitor". Biochemistry. 35 (1): 266–72. doi:10.1021/bi951501d. PMID   8555184.
• Miyagi Y, Yasumitsu H, Eki T, et al. (1996). "Assignment of the human PP5/TFPI-2 gene to 7q22 by FISH and PCR-based human/rodent cell hybrid mapping panel analysis". Genomics. 35 (1): 267–8. doi:10.1006/geno.1996.0353. PMID   8661135.
• Rao CN, Reddy P, Liu Y, et al. (1996). "Extracellular matrix-associated serine protease inhibitors (Mr 33,000, 31,000, and 27,000) are single-gene products with differential glycosylation: cDNA cloning of the 33-kDa inhibitor reveals its identity to tissue factor pathway inhibitor-2". Arch. Biochem. Biophys. 335 (1): 82–92. doi:10.1006/abbi.1996.0484. PMID   8914837.
• Iino M, Foster DC, Kisiel W (1998). "Quantification and characterization of human endothelial cell-derived tissue factor pathway inhibitor-2". Arterioscler. Thromb. Vasc. Biol. 18 (1): 40–6. doi: 10.1161/01.ATV.18.1.40 . PMID   9445254.
• Udagawa K, Miyagi Y, Hirahara F, et al. (1998). "Specific expression of PP5/TFPI2 mRNA by syncytiotrophoblasts in human placenta as revealed by in situ hybridization". Placenta. 19 (2–3): 217–23. doi:10.1016/S0143-4004(98)90011-X. PMID   9548189.
• Shinoda E, Yui Y, Hattori R, et al. (1999). "Tissue factor pathway inhibitor-2 is a novel mitogen for vascular smooth muscle cells". J. Biol. Chem. 274 (9): 5379–84. doi: 10.1074/jbc.274.9.5379 . hdl: 2433/181716 . PMID   10026147.
• Liu Y, Stack SM, Lakka SS, et al. (1999). "Matrix localization of tissue factor pathway inhibitor-2/matrix-associated serine protease inhibitor (TFPI-2/MSPI) involves arginine-mediated ionic interactions with heparin and dermatan sulfate: heparin accelerates the activity of TFPI-2/MSPI toward plasmin". Arch. Biochem. Biophys. 370 (1): 112–8. doi:10.1006/abbi.1999.1371. PMID   10496984.
• Kamei S, Kazama Y, Kuijper JL, et al. (2001). "Genomic structure and promoter activity of the human tissue factor pathway inhibitor-2 gene". Biochim. Biophys. Acta. 1517 (3): 430–5. doi:10.1016/S0167-4781(00)00298-0. PMID   11342222.
• Crawley JT, Goulding DA, Ferreira V, et al. (2002). "Expression and localization of tissue factor pathway inhibitor-2 in normal and atherosclerotic human vessels". Arterioscler. Thromb. Vasc. Biol. 22 (2): 218–24. doi: 10.1161/hq0102.101842 . PMID   11834519.
• Udagawa K, Yasumitsu H, Esaki M, et al. (2002). "Subcellular localization of PP5/TFPI-2 in human placenta: a possible role of PP5/TFPI-2 as an anti-coagulant on the surface of syncytiotrophoblasts". Placenta. 23 (2–3): 145–53. doi:10.1053/plac.2001.0774. PMID   11945080.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hubé F, Reverdiau P, Iochmann S, et al. (2003). "Demonstration of a tissue factor pathway inhibitor 2 messenger RNA synthesis by pure villous cytotrophoblast cells isolated from term human placentas". Biol. Reprod. 68 (5): 1888–94. doi: 10.1095/biolreprod.102.011858 . PMID   12606321. S2CID   32145819.
• George J, Gondi CS, Dinh DH, Gujrati M, Rao JS (2007). "Restoration of TFPI-2 in a Human Glioblastoma Cell Line Triggers Caspase Mediated Pathway and Apoptosis". Clin. Cancer Res. 13 (12): 3507–3517. doi:10.1158/1078-0432.CCR-06-3023. PMC   1905856 . PMID   17575213.
• Rao CN, Segawa T, Navari JR, et al. (2003). "Methylation of TFPI-2 gene is not the sole cause of its silencing". Int. J. Oncol. 22 (4): 843–8. doi:10.3892/ijo.22.4.843. PMID   12632077.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.