THAP7

THAP7
Identifiers
Aliases	THAP7 , THAP domain containing 7
External IDs	OMIM: 609518; MGI: 1916259; HomoloGene: 12293; GeneCards: THAP7; OMA:THAP7 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q11.21 Start 20,999,104 bp [1] End 21,002,196 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16 A3|16 Start 17,345,846 bp [2] End 17,349,000 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary right testis muscle of thigh left testis apex of heart gastric mucosa gastrocnemius muscle left uterine tube right lobe of liver gonad Top expressed in fossa internal carotid artery primary oocyte external carotid artery motor neuron condyle spermatocyte proximal tubule right kidney spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding C2H2 zinc finger domain binding protein binding metal ion binding protein N-terminus binding nucleic acid binding identical protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nuclear speck chromosome nucleus nuclear membrane intracellular membrane-bounded organelle Biological process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80764 69009 Ensembl ENSG00000184436 ENSMUSG00000022760 UniProt Q9BT49 Q8VCZ3 RefSeq (mRNA) NM_030573 NM_001008695 NM_001008696 NM_026909 RefSeq (protein) NP_001008695 NP_085050 NP_081185 Location (UCSC) Chr 22: 21 – 21 Mb Chr 16: 17.35 – 17.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

THAP domain-containing protein 7 is a protein that in humans is encoded by the THAP7 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000184436 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022760 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Roussigne M, Kossida S, Lavigne AC, Clouaire T, Ecochard V, Glories A, Amalric F, Girard JP (Feb 2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase". Trends Biochem Sci. 28 (2): 66–9. doi:10.1016/S0968-0004(02)00013-0. PMID   12575992.
6. "Entrez Gene: THAP7 THAP domain containing 7".

Further reading

• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID   16341674. S2CID   69278.
• Macfarlan T, Parker JB, Nagata K, Chakravarti D (2006). "Thanatos-associated protein 7 associates with template activating factor-Ibeta and inhibits histone acetylation to repress transcription". Mol. Endocrinol. 20 (2): 335–47. doi: 10.1210/me.2005-0248 . PMID   16195249.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Macfarlan T, Kutney S, Altman B, et al. (2005). "Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor". J. Biol. Chem. 280 (8): 7346–58. doi: 10.1074/jbc.M411675200 . PMID   15561719.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.