THAP7

THAP7
Identifiers
Aliases	THAP7 , THAP domain containing 7
External IDs	OMIM: 609518 MGI: 1916259 HomoloGene: 12293 GeneCards: THAP7
Gene location (Human)
Chr.	Chromosome 22 (human)
End	21,002,196 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	17,349,000 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; gastric mucosa; ; gastrocnemius muscle; ; left uterine tube; ; right lobe of liver; ; canal of the cervix; ; Left adrenal gland; ; body of stomach; ; prefrontal cortex; ; right uterine tube;
	Top expressed in
	fossa; ; internal carotid artery; ; external carotid artery; ; motor neuron; ; condyle; ; spermatocyte; ; proximal tubule; ; spermatid; ; substantia nigra; ; seminiferous tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding ; C2H2 zinc finger domain binding ; protein binding ; metal ion binding ; protein N-terminus binding ; nucleic acid binding ; identical protein binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	nuclear speck ; chromosome ; nucleus ; nuclear membrane ; intracellular membrane-bounded organelle ;
Biological process	negative regulation of transcription, DNA-templated ; regulation of transcription, DNA-templated ; transcription, DNA-templated ; regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	80764
	69009
	ENSG00000184436
	ENSMUSG00000022760
	Q9BT49
	Q8VCZ3
	NM_030573 ; NM_001008695 ; NM_001008696
	NM_026909
	NP_001008695 ; NP_085050
	NP_081185
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 05, 2022

THAP domain-containing protein 7 is a protein that in humans is encoded by the THAP7 gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000184436 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022760 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Roussigne M, Kossida S, Lavigne AC, Clouaire T, Ecochard V, Glories A, Amalric F, Girard JP (Feb 2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase". Trends Biochem Sci. 28 (2): 66–9. doi:10.1016/S0968-0004(02)00013-0. PMID 12575992.
↑ "Entrez Gene: THAP7 THAP domain containing 7".

Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Macfarlan T, Parker JB, Nagata K, Chakravarti D (2006). "Thanatos-associated protein 7 associates with template activating factor-Ibeta and inhibits histone acetylation to repress transcription". Mol. Endocrinol. 20 (2): 335–47. doi: 10.1210/me.2005-0248 . PMID 16195249.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Macfarlan T, Kutney S, Altman B, et al. (2005). "Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor". J. Biol. Chem. 280 (8): 7346–58. doi: 10.1074/jbc.M411675200 . PMID 15561719.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604 . PMID 15461802.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000184436 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022760 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12575992-5] Roussigne M, Kossida S, Lavigne AC, Clouaire T, Ecochard V, Glories A, Amalric F, Girard JP (Feb 2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase". Trends Biochem Sci. 28 (2): 66–9. doi:10.1016/S0968-0004(02)00013-0. PMID 12575992.

[entrez-6] "Entrez Gene: THAP7 THAP domain containing 7".

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THAP7

Related Research Articles

References

Further reading