THOC1

THOC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WXP
Identifiers
Aliases	THOC1 , HPR1, P84, P84N5, THO complex 1
External IDs	OMIM: 606930 MGI: 1919668 HomoloGene: 38012 GeneCards: THOC1
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18p11.32 Start 214,520 bp [1] End 268,050 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 A1 Start 9,957,906 bp [2] End 9,995,489 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon cerebellar hemisphere right uterine tube anterior pituitary corpus callosum left lobe of thyroid gland body of pancreas tibial nerve right lobe of thyroid gland canal of the cervix Top expressed in cumulus cell spermatocyte external carotid artery abdominal wall primitive streak spermatid internal carotid artery supraoptic nucleus dermis semi-lunar valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding RNA binding Cellular component cytoplasm transcription export complex nuclear matrix intercellular bridge THO complex THO complex part of transcription export complex nucleus nucleoplasm cytosol nuclear speck Biological process regulation of DNA recombination mRNA transport RNA processing regulation of transcription, DNA-templated negative regulation of DNA damage checkpoint mRNA processing regulation of DNA-templated transcription, elongation viral mRNA export from host cell nucleus transcription, DNA-templated positive regulation of DNA-templated transcription, elongation negative regulation of isotype switching to IgA isotypes RNA splicing replication fork processing signal transduction apoptotic process RNA export from nucleus mRNA export from nucleus mRNA 3'-end processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9984 225160 Ensembl ENSG00000079134 ENSMUSG00000024287 UniProt Q96FV9 Q8R3N6 RefSeq (mRNA) NM_005131 NM_153552 RefSeq (protein) NP_005122 NP_705780 Location (UCSC) Chr 18: 0.21 – 0.27 Mb Chr 18: 9.96 – 10 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

THO complex subunit 1 is a protein that in humans is encoded by the THOC1 gene. ^{[5] [6]}

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 606390).[supplied by OMIM] ^[6]

Interactions

THOC1 has been shown to interact with Retinoblastoma protein. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000079134 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024287 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E (May 2002). "TREX is a conserved complex coupling transcription with messenger RNA export". Nature. 417 (6886): 304–8. Bibcode:2002Natur.417..304S. doi:10.1038/nature746. PMID   11979277. S2CID   1112194.
6. "Entrez Gene: THOC1 THO complex 1".
7. Durfee, T; Mancini M A; Jones D; Elledge S J; Lee W H (November 1994). "The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing". J. Cell Biol. 127 (3): 609–22. doi:10.1083/jcb.127.3.609. ISSN   0021-9525. PMC   2120229 . PMID   7525595.

Further reading

• Durfee T, Mancini MA, Jones D, et al. (1994). "The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing". J. Cell Biol. 127 (3): 609–22. doi:10.1083/jcb.127.3.609. PMC   2120229 . PMID   7525595.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Dennehey BK, Gutches DG, McConkey EH, Krauter KS (2004). "Inversion, duplication, and changes in gene context are associated with human chromosome 18 evolution". Genomics. 83 (3): 493–501. doi:10.1016/j.ygeno.2003.08.017. PMID   14962675.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gasparri F, Sola F, Locatelli G, Muzio M (2004). "The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm". FEBS Lett. 574 (1–3): 13–9. doi:10.1016/j.febslet.2004.07.074. PMID   15358532. S2CID   43023236.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Li Y, Wang X, Zhang X, Goodrich DW (2005). "Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors". Mol. Cell. Biol. 25 (10): 4023–33. doi:10.1128/MCB.25.10.4023-4033.2005. PMC   1087710 . PMID   15870275.
• Masuda S, Das R, Cheng H, et al. (2005). "Recruitment of the human TREX complex to mRNA during splicing". Genes Dev. 19 (13): 1512–7. doi:10.1101/gad.1302205. PMC   1172058 . PMID   15998806.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Li Y, Lin AW, Zhang X, et al. (2007). "Cancer cells and normal cells differ in their requirements for Thoc1". Cancer Res. 67 (14): 6657–64. doi:10.1158/0008-5472.CAN-06-3234. PMC   2804983 . PMID   17638875.
• Garner E, Martinon F, Tschopp J, et al. (2007). "Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6". Cancer Res. 67 (16): 7631–7. doi: 10.1158/0008-5472.CAN-07-0334 . PMID   17699767.