THRAP3

THRAP3
Identifiers
Aliases	THRAP3 , TRAP150, thyroid hormone receptor associated protein 3, BCLAF2
External IDs	OMIM: 603809 MGI: 2442637 HomoloGene: 31289 GeneCards: THRAP3
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p34.3 Start 36,224,416 bp [1] End 36,305,357 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D2.2 Start 126,164,082 bp [2] End 126,202,760 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle Achilles tendon ganglionic eminence stromal cell of endometrium gastric mucosa right coronary artery right lobe of thyroid gland popliteal artery left lobe of thyroid gland gallbladder Top expressed in spermatocyte yolk sac lip thymus ganglionic eminence spleen superior frontal gyrus spermatid vas deferens cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding transcription coactivator activity transcription coregulator activity thyroid hormone receptor binding phosphoprotein binding core promoter sequence-specific DNA binding protein binding nuclear receptor coactivator activity ATP binding vitamin D receptor binding RNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding signaling receptor activity Cellular component nuclear speck mediator complex exon-exon junction complex nucleoplasm extracellular exosome nucleus Biological process androgen receptor signaling pathway regulation of transcription, DNA-templated positive regulation of mRNA splicing, via spliceosome rhythmic process mRNA processing intracellular steroid hormone receptor signaling pathway regulation of alternative mRNA splicing, via spliceosome transcription, DNA-templated positive regulation of transcription, DNA-templated nuclear-transcribed mRNA catabolic process mRNA stabilization circadian rhythm RNA splicing positive regulation of circadian rhythm transcription initiation from RNA polymerase II promoter positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9967 230753 Ensembl ENSG00000054118 ENSMUSG00000043962 UniProt Q9Y2W1 Q569Z6 RefSeq (mRNA) NM_005119 NM_001321471 NM_001321473 NM_146153 NM_001356455 NM_001356456 RefSeq (protein) NP_001308400 NP_001308402 NP_005110 NP_666265 NP_001343384 NP_001343385 Location (UCSC) Chr 1: 36.22 – 36.31 Mb Chr 4: 126.16 – 126.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Thyroid hormone receptor-associated protein 3 is a protein that in humans is encoded by the THRAP3 gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000054118 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043962 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: THRAP3 thyroid hormone receptor associated protein 3".

Further reading

• Fondell JD, Ge H, Roeder RG (1996). "Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8329–33. Bibcode:1996PNAS...93.8329F. doi: 10.1073/pnas.93.16.8329 . PMC   38670 . PMID   8710870.
• Ito M, Yuan CX, Malik S, et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. 3 (3): 361–70. doi: 10.1016/S1097-2765(00)80463-3 . PMID   10198638.
• Rachez C, Lemon BD, Suldan Z, et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. Bibcode:1999Natur.398..824R. doi:10.1038/19783. PMID   10235266. S2CID   204992765.
• Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. Bibcode:1999Natur.398..828N. doi:10.1038/19789. PMID   10235267. S2CID   23646963.
• Ge K, Guermah M, Yuan CX, et al. (2002). "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis". Nature. 417 (6888): 563–7. Bibcode:2002Natur.417..563G. doi:10.1038/417563a. PMID   12037571. S2CID   4432077.
• Johnson KM, Wang J, Smallwood A, et al. (2002). "TFIID and human mediator coactivator complexes assemble cooperatively on promoter DNA". Genes Dev. 16 (14): 1852–63. doi:10.1101/gad.995702. PMC   186393 . PMID   12130544.
• Wang Q, Sharma D, Ren Y, Fondell JD (2003). "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression". J. Biol. Chem. 277 (45): 42852–8. doi: 10.1074/jbc.M206061200 . PMID   12218053.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC   207616 . PMID   14559993.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID   15144186.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660. S2CID   2371325.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.