THSD1

THSD1
Identifiers
Aliases	THSD1 , TMTSP, UNQ3010, thrombospondin type 1 domain containing 1, ANIB12
External IDs	OMIM: 616821 MGI: 1929096 HomoloGene: 10264 GeneCards: THSD1
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q14.3 Start 52,377,167 bp [1] End 52,416,373 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 A2 Start 22,717,329 bp [2] End 22,751,350 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung placenta upper lobe of left lung subcutaneous adipose tissue temporal lobe amygdala left ventricle caudate nucleus tibial nerve ganglionic eminence Top expressed in external carotid artery internal carotid artery left lung lobe lip skin of back right lung lobe hair follicle dermis yolk sac atrium More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 55901 56229 Ensembl ENSG00000136114 ENSMUSG00000031480 UniProt Q9NS62 Q9JM61 RefSeq (mRNA) NM_199263 NM_018676 NM_001205253 NM_001293688 NM_019576 RefSeq (protein) NP_061146 NP_954872 NP_001192182 NP_001280617 NP_062522 Location (UCSC) Chr 13: 52.38 – 52.42 Mb Chr 8: 22.72 – 22.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Thrombospondin type-1 domain-containing protein 1 is a protein that in humans is encoded by the THSD1 gene. ^[5]

The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in thrombospondin, a number of proteins involved in the complement pathway, as well as extracellular matrix proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000136114 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031480 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: THSD1 thrombospondin, type I, domain containing 1".

Further reading

• Bork P (1993). "The modular architecture of a new family of growth regulators related to connective tissue growth factor". FEBS Lett. 327 (2): 125–30. doi: 10.1016/0014-5793(93)80155-N . PMID   7687569.
• Gruber HE, Ingram JA, Hanley EN (2007). "Immunolocalization of thrombospondin in the human and sand rat intervertebral disc". Spine. 31 (22): 2556–61. doi:10.1097/01.brs.0000241117.31510.e3. PMID   17047544. S2CID   43521262.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Orr AW, Pallero MA, Xiong WC, Murphy-Ullrich JE (2005). "Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly". J. Biol. Chem. 279 (47): 48983–92. doi: 10.1074/jbc.M404881200 . PMID   15371459.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC   2665288 . PMID   15057823.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.