THYN1

THYN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EOP, 5J3E
Identifiers
Aliases	THYN1 , MDS012, MY105, THY28, THY28KD, HSPC144, thymocyte nuclear protein 1
External IDs	OMIM: 613739 MGI: 1925112 HomoloGene: 8575 GeneCards: THYN1
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q25 Start 134,248,279 bp [1] End 134,253,370 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A4 Start 26,911,006 bp [2] End 26,918,632 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte anterior pituitary Brodmann area 9 nucleus accumbens ganglionic eminence caudate nucleus amygdala putamen right uterine tube prefrontal cortex Top expressed in endocardial cushion spermatocyte cerebellar cortex superior frontal gyrus yolk sac ganglionic eminence morula abdominal wall spermatid maxillary prominence More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 29087 77862 Ensembl ENSG00000151500 ENSMUSG00000035443 UniProt Q9P016 Q91YJ3 RefSeq (mRNA) NM_001037304 NM_001037305 NM_014174 NM_199297 NM_199298 NM_144543 NM_001326361 RefSeq (protein) NP_001032381 NP_001032382 NP_054893 NP_954994 NP_954995 NP_001313290 NP_653126 Location (UCSC) Chr 11: 134.25 – 134.25 Mb Chr 9: 26.91 – 26.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Thymocyte nuclear protein 1 is a protein that in humans is encoded by the THYN1 gene. ^{[5] [6] [7]}

This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000151500 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035443 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jiang XZ, Toyota H, Yoshimoto T, Takada E, Asakura H, Mizuguchi J (Nov 2003). "Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in Ramos B lymphoma cells". Apoptosis. 8 (5): 509–19. doi:10.1023/A:1025594409056. PMID   14601557. S2CID   2092518.
6. Miyaji H, Yoshimoto T, Asakura H, Komachi A, Kamiya S, Takasaki M, Mizuguchi J (Oct 2002). "Molecular cloning and characterization of the mouse thymocyte protein gene". Gene. 297 (1–2): 189–96. doi:10.1016/S0378-1119(02)00886-7. PMID   12384300.
7. "Entrez Gene: THYN1 thymocyte nuclear protein 1".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID   12107411.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Jiang X, Toyota H, Takada E, et al. (2004). "Modulation of mThy28 nuclear protein expression during thymocyte development". Tissue & Cell. 35 (6): 471–8. doi:10.1016/S0040-8166(03)00073-9. PMID   14580360.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Song AX, Chang YG, Gao YG, et al. (2005). "Identification, expression, and purification of a unique stable domain from human HSPC144 protein". Protein Expr. Purif. 42 (1): 146–52. doi:10.1016/j.pep.2005.03.008. PMID   15939300.