TIMM13

TIMM13
Identifiers
Aliases	TIMM13 , TIM13, TIM13B, TIMM13A, TIMM13B, ppv1, translocase of inner mitochondrial membrane 13
External IDs	OMIM: 607383; MGI: 1353432; HomoloGene: 40846; GeneCards: TIMM13; OMA:TIMM13 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 2,425,625 bp [1] End 2,427,586 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 C1|10 39.72 cM Start 80,735,284 bp [2] End 80,736,803 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon apex of heart right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex right lobe of liver prefrontal cortex muscle of thigh body of pancreas Top expressed in yolk sac proximal tubule right kidney neural tube white adipose tissue quadriceps femoris muscle adrenal gland blastocyst pancreas mesencephalon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding metal ion binding Cellular component mitochondrial intermembrane space protein transporter complex membrane mitochondrion fibrillar center mitochondrial inner membrane mitochondrial intermembrane space Biological process protein transport protein targeting to mitochondrion hearing protein insertion into mitochondrial inner membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26517 30055 Ensembl ENSG00000099800 ENSMUSG00000020219 UniProt Q9Y5L4 P62075 RefSeq (mRNA) NM_012458 NM_013895 RefSeq (protein) NP_036590 NP_038923 Location (UCSC) Chr 19: 2.43 – 2.43 Mb Chr 10: 80.74 – 80.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mitochondrial import inner membrane translocase subunit Tim13 is an enzyme that in humans is encoded by the TIMM13 gene. ^{[5] [6] [7]}

Function

This gene encodes a translocase with similarity to yeast mitochondrial proteins that are involved in the import of metabolite transporters from the cytoplasm and into the mitochondrial inner membrane. The encoded protein and the TIMM8a protein form a 70 kDa complex in the intermembrane space. This gene is in a head-to-tail orientation with the gene for lamin B2. ^[7]

Interactions

TIMM13 has been shown to interact with TIMM8A. ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000099800 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020219 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jin H, Kendall E, Freeman TC, Roberts RG, Vetrie DL (Nov 1999). "The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins". Genomics. 61 (3): 259–67. doi:10.1006/geno.1999.5966. PMID   10552927.
6. Gentle IE, Perry AJ, Alcock FH, Likić VA, Dolezal P, Ng ET, Purcell AW, McConnville M, Naderer T, Chanez AL, Charrière F, Aschinger C, Schneider A, Tokatlidis K, Lithgow T (May 2007). "Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space". Molecular Biology and Evolution. 24 (5): 1149–60. doi: 10.1093/molbev/msm031 . PMID   17329230.
7. "Entrez Gene: TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)".
8. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1) 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
9. Roesch K, Curran SP, Tranebjaerg L, Koehler CM (Mar 2002). "Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex". Human Molecular Genetics. 11 (5): 477–86. doi: 10.1093/hmg/11.5.477 . PMID   11875042.

Further reading

• Rehling P, Wiedemann N, Pfanner N, Truscott KN (2001). "The mitochondrial import machinery for preproteins". Critical Reviews in Biochemistry and Molecular Biology. 36 (3): 291–336. doi:10.1080/20014091074200. PMID   11450972. S2CID   8758017.
• Paschen SA, Neupert W (2002). "Protein import into mitochondria". IUBMB Life. 52 (3–5): 101–12. doi: 10.1080/15216540152845894 . PMID   11798021. S2CID   31047665.
• Neupert W, Brunner M (Aug 2002). "The protein import motor of mitochondria". Nature Reviews. Molecular Cell Biology. 3 (8): 555–65. doi:10.1038/nrm878. PMID   12154367. S2CID   5706589.
• Jensen RE, Dunn CD (Sep 2002). "Protein import into and across the mitochondrial inner membrane: role of the TIM23 and TIM22 translocons". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1592 (1): 25–34. doi:10.1016/S0167-4889(02)00261-6. PMID   12191765.
• Bauer MF, Rothbauer U, Mühlenbein N, Smith RJ, Gerbitz K, Neupert W, Brunner M, Hofmann S (Dec 1999). "The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom". FEBS Letters. 464 (1–2): 41–7. Bibcode:1999FEBSL.464...41B. doi: 10.1016/S0014-5793(99)01665-8 . PMID   10611480. S2CID   27484018.
• Paschen SA, Rothbauer U, Káldi K, Bauer MF, Neupert W, Brunner M (Dec 2000). "The role of the TIM8-13 complex in the import of Tim23 into mitochondria". The EMBO Journal. 19 (23): 6392–400. doi:10.1093/emboj/19.23.6392. PMC   305865 . PMID   11101512.
• Rothbauer U, Hofmann S, Mühlenbein N, Paschen SA, Gerbitz KD, Neupert W, Brunner M, Bauer MF (Oct 2001). "Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria". The Journal of Biological Chemistry. 276 (40): 37327–34. doi: 10.1074/jbc.M105313200 . PMID   11489896.
• Roesch K, Curran SP, Tranebjaerg L, Koehler CM (Mar 2002). "Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex". Human Molecular Genetics. 11 (5): 477–86. doi: 10.1093/hmg/11.5.477 . PMID   11875042.
• Chacinska A, Pfanner N, Meisinger C (Jul 2002). "How mitochondria import hydrophilic and hydrophobic proteins". Trends in Cell Biology. 12 (7): 299–303. doi:10.1016/S0962-8924(02)02310-3. PMID   12185844.
• Curran SP, Leuenberger D, Schmidt E, Koehler CM (Sep 2002). "The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins". The Journal of Cell Biology. 158 (6): 1017–27. doi:10.1083/jcb.200205124. PMC   2173223 . PMID   12221072.
• Roesch K, Hynds PJ, Varga R, Tranebjaerg L, Koehler CM (Sep 2004). "The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex". Human Molecular Genetics. 13 (18): 2101–11. doi: 10.1093/hmg/ddh217 . PMID   15254020.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1) 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.