TINAGL1

TINAGL1
Identifiers
Aliases	TINAGL1 , ARG1, LCN7, LIECG3, TINAGRP, tubulointerstitial nephritis antigen like 1
External IDs	OMIM: 616064; MGI: 2137617; HomoloGene: 41472; GeneCards: TINAGL1; OMA:TINAGL1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p35.2 Start 31,576,485 bp [1] End 31,587,686 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D2.2 Start 130,058,247 bp [2] End 130,068,915 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery ascending aorta popliteal artery tibial arteries Descending thoracic aorta apex of heart left coronary artery right lobe of thyroid gland left lobe of thyroid gland left uterine tube Top expressed in granulocyte ascending aorta decidua yolk sac external carotid artery umbilical cord endothelial cell of lymphatic vessel pyloric antrum aortic valve tunica media of zone of aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function scavenger receptor activity polysaccharide binding cysteine-type endopeptidase activity laminin binding extracellular matrix structural constituent protein binding cysteine-type peptidase activity Cellular component cytoplasm extracellular matrix extracellular region lysosome extracellular exosome extracellular space collagen-containing extracellular matrix Biological process endosomal transport cell adhesion proteolysis involved in cellular protein catabolic process receptor-mediated endocytosis immune response proteolysis endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64129 94242 Ensembl ENSG00000142910 ENSMUSG00000028776 UniProt Q9GZM7 Q99JR5 RefSeq (mRNA) NM_001204414 NM_001204415 NM_022164 NM_001168333 NM_023476 RefSeq (protein) NP_001191343 NP_001191344 NP_071447 NP_001161805 NP_075965 Location (UCSC) Chr 1: 31.58 – 31.59 Mb Chr 4: 130.06 – 130.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tubulointerstitial nephritis antigen-like is a protein that in humans is encoded by the TINAGL1 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000142910 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028776 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wex T, Lipyansky A, Bromme NC, Wex H, Guan XQ, Bromme D (Feb 2001). "TIN-ag-RP, a novel catalytically inactive cathepsin B-related protein with EGF domains, is predominantly expressed in vascular smooth muscle cells". Biochemistry. 40 (5): 1350–7. doi:10.1021/bi002266o. PMID   11170462.
6. "Entrez Gene: TINAGL1 tubulointerstitial nephritis antigen-like 1".

Further reading

• Brömme NC, Wex T, Wex H, et al. (2000). "Cloning, characterization, and expression of the human TIN-ag-RP gene encoding a novel putative extracellular matrix protein". Biochem. Biophys. Res. Commun. 271 (2): 474–80. doi:10.1006/bbrc.2000.2639. PMID   10799322.
• Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system". Hypertens. Res. 25 (4): 647–52. doi: 10.1291/hypres.25.647 . PMID   12358155.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Umeyama H, Iwadate M, Taguchi YH (2014). "TINAGL1 and B3GALNT1 are potential therapy target genes to suppress metastasis in non-small cell lung cancer". BMC Genomics. 15 (Suppl 9): S2. doi: 10.1186/1471-2164-15-S9-S2 . PMC   4290609 . PMID   25521548.
• Bosse K, Haneder S, Arlt C, Ihling CH, Seufferlein T, Sinz A (2016). "Mass spectrometry-based secretome analysis of non-small cell lung cancer cell lines". Proteomics. 16 (21): 2801–2814. doi:10.1002/pmic.201600297. PMID   27569058. S2CID   38155519.