TINP1

NSA2
Identifiers
Aliases	NSA2 , CDK105, HCL-G1, HCLG1, HUSSY29, TINP1, HUSSY-29, ribosome biogenesis homolog, NSA2 ribosome biogenesis factor
External IDs	OMIM: 612497; MGI: 1913883; HomoloGene: 5844; GeneCards: NSA2; OMA:NSA2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q13.3 Start 74,766,991 bp [1] End 74,780,113 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 D1 Start 97,265,932 bp [2] End 97,274,445 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon parotid gland skin of thigh skin of hip hair follicle glutes germinal epithelium parietal pleura tail of epididymis left ovary Top expressed in genital tubercle tail of embryo ventricular zone esophagus yolk sac embryo embryo muscle of thigh lip morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA binding Cellular component preribosome, large subunit precursor nucleus nucleolus Biological process rRNA processing ribosome biogenesis maturation of LSU-rRNA maturation of 5.8S rRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10412 59050 Ensembl ENSG00000164346 ENSMUSG00000060739 UniProt O95478 Q9CR47 RefSeq (mRNA) NM_001271665 NM_014886 NM_001364506 NM_021552 RefSeq (protein) NP_001258594 NP_055701 NP_001351435 NP_067527 Location (UCSC) Chr 5: 74.77 – 74.78 Mb Chr 13: 97.27 – 97.27 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

TGF beta-inducible nuclear protein 1 is a protein that in humans is encoded by the NSA2 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000164346 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060739 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (January 2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi: 10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H . PMID   11124703. S2CID   21397515.
6. Wu X, Ivanova G, Merup M, Jansson M, Stellan B, Grandér D, Zabarovsky E, Gahrton G, Einhorn S (September 1999). "Molecular analysis of the human chromosome 5q13.3 region in patients with hairy cell leukemia and identification of tumor suppressor gene candidates". Genomics. 60 (2): 161–71. doi:10.1006/geno.1999.5911. PMID   10486207.
7. "Entrez Gene: TINP1 TGF beta-inducible nuclear protein 1".

Further reading

• Lebreton A, Saveanu C, Decourty L, Jacquier A, Fromont-Racine M (September 2006). "Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs". The Journal of Biological Chemistry. 281 (37): 27099–108. doi: 10.1074/jbc.M602199200 . PMID   16861225.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (November 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC   133617 . PMID   12429849.