TIMELESS-interacting protein is a protein that in humans is encoded by the TIPIN gene. [5] [6] [7]
TIMELESS-interacting protein is a protein that in humans is encoded by the TIPIN gene. [5] [6] [7]
TIPIN has been shown to interact with Replication protein A1. [8]
Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ATR gene. It is a large kinase of about 301.66 kDa. ATR belongs to the phosphatidylinositol 3-kinase-related kinase protein family. ATR is activated in response to single strand breaks, and works with ATM to ensure genome integrity.
Timeless (tim) is a gene in multiple species but is most notable for its role in Drosophila for encoding TIM, an essential protein that regulates circadian rhythm. Timeless mRNA and protein oscillate rhythmically with time as part of a transcription-translation negative feedback loop involving the period (per) gene and its protein.
Eukaryotic DNA replication is a conserved mechanism that restricts DNA replication to once per cell cycle. Eukaryotic DNA replication of chromosomal DNA is central for the duplication of a cell and is necessary for the maintenance of the eukaryotic genome.
Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene.
Cell cycle checkpoint control protein RAD9A is a protein that in humans is encoded by the RAD9A gene.Rad9 has been shown to induce G2 arrest in the cell cycle in response to DNA damage in yeast cells. Rad9 was originally found in budding yeast cells but a human homolog has also been found and studies have suggested that the molecular mechanisms of the S and G2 checkpoints are conserved in eukaryotes. Thus, what is found in yeast cells are likely to be similar in human cells.
Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene.
Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene.
Checkpoint protein HUS1 is a protein that in humans is encoded by the HUS1 gene.
Eukaryotic translation initiation factor 4 gamma 1 is a protein that in humans is encoded by the EIF4G1 gene.
General transcription factor II-I is a protein that in humans is encoded by the GTF2I gene.
Cell cycle checkpoint protein RAD1 is a protein that in humans is encoded by the RAD1 gene.
Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene.
Replication factor C subunit 4 is a protein that in humans is encoded by the RFC4 gene.
Chromatin assembly factor 1 subunit A is a protein that in humans is encoded by the CHAF1A gene.
Replication factor C subunit 3 is a protein that in humans is encoded by the RFC3 gene.
Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene. The Cdc7 kinase is involved in regulation of the cell cycle at the point of chromosomal DNA replication. The gene CDC7 appears to be conserved throughout eukaryotic evolution; this means that most eukaryotic cells have the Cdc7 kinase protein.
Chromatin assembly factor 1 subunit B is a protein that in humans is encoded by the CHAF1B gene.
Protein DBF4 homolog A is a protein that is encoded by the DBF4 gene in humans.
Origin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene. It is closely related to CDC6, and both are the same protein in archaea.
Replication protein A 32 kDa subunit is a protein that in humans is encoded by the RPA2 gene.
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