TMBIM4

TMBIM4
Identifiers
Aliases	TMBIM4 , GAAP, LFG4, S1R, ZPRO, CGI-119, transmembrane BAX inhibitor motif containing 4
External IDs	OMIM: 616874; MGI: 1915462; HomoloGene: 56740; GeneCards: TMBIM4; OMA:TMBIM4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q14.3 Start 66,135,846 bp [1] End 66,170,027 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 D2 Start 120,037,495 bp [2] End 120,060,822 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell monocyte Achilles tendon body of pancreas right lung left adrenal gland left testis right testis right adrenal gland right adrenal cortex Top expressed in right kidney interventricular septum yolk sac human kidney seminal vesicula proximal tubule granulocyte neural layer of retina spermatocyte spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane Golgi apparatus Golgi membrane Golgi stack membrane Biological process regulation of calcium-mediated signaling negative regulation of apoptotic process apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51643 68212 Ensembl ENSG00000155957 ENSMUSG00000020225 UniProt Q9HC24 Q9DA39 RefSeq (mRNA) NM_016056 NM_001282606 NM_001282609 NM_001282610 NM_026617 RefSeq (protein) NP_001269535 NP_001269538 NP_001269539 NP_057140 NP_001269535.1 NP_080893 Location (UCSC) Chr 12: 66.14 – 66.17 Mb Chr 10: 120.04 – 120.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transmembrane BAX inhibitor motif-containing protein 4 is a protein that in humans is encoded by the TMBIM4 gene. ^{[5] [6] [7]} It is also known as humanGolgi anti-apoptotic protein (hGAAP) due to its function and sub-cellular localization.

Function

Human GAAP ^[8] is a protein present in the Golgi that helps regulate apoptosis, a form of programmed cell death. By regulating the fluxes of Ca⁺², an increase of GAAP can help prevent apoptosis. ^{[9] [10]} GAAP is also involved in promoting cell migration ^{[11] [12]} and has been identified as a novel Golgi cation channel. ^[13] Other GAAPs can be found in all eucaryotes analyzed and in some bacteria. A viral GAAP (vGAAP) can also be found in some strains of vaccinia virus, the live vaccine used to eradicate smallpox.

See also

• Golgi
• Apoptosis
• Ion channel
• Cell migration

References

1. GRCh38: Ensembl release 89: ENSG00000155957 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020225 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
6. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC   310876 . PMID   10810093.
7. "Entrez Gene: TMBIM4 transmembrane BAX inhibitor motif containing 4".
8. Saraiva, Nuno; Carrara, Guia; Smith, Geoffrey L (2017). "Golgi anti-apoptotic protein: a tale of camels, calcium, channels and cancer". Open Biology. 7(5):170045. (5): 170045. doi: 10.1098/rsob.170045 . PMC   5451544 . PMID   28469007.
9. de Mattia F, Gubser C, van Dommelen MM, Visch HJ, Distelmaier F, Postigo A, Luyten T, Parys JB, de Smedt H, Smith GL, Willems PH, van Kuppeveld FJ (August 2009). "Human Golgi antiapoptotic protein modulates intracellular calcium fluxes". Molecular Biology of the Cell. 20 (16): 3638–45. doi:10.1091/mbc.E09-05-0385. PMC   2777924 . PMID   19553469.
10. Saraiva N, Prole DL, Carrara G, Maluquer de Motes C, Johnson BF, Byrne B, Taylor CW, Smith GL (May 2013). "Human and viral Golgi anti-apoptotic proteins (GAAPs) oligomerize via different mechanisms and monomeric GAAP inhibits apoptosis and modulates calcium". The Journal of Biological Chemistry. 288 (18): 13057–67. doi: 10.1074/jbc.M112.414367 . PMC   3642348 . PMID   23508950.
11. Saraiva, Nuno; Prole, David L.; Carrara, Guia; Johnson, Benjamin F.; Taylor, Colin W.; Parsons, Maddy; Smith, Geoffrey L. (2013-08-19). "hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2". J Cell Biol. 202 (4): 699–713. doi:10.1083/jcb.201301016. ISSN   0021-9525. PMC   3747308 . PMID   23940116.
12. Almeida, Nuno; Saraiva, Nuno (2020). "Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism". Redox Biology. 28:101361: 101361. doi: 10.1016/j.redox.2019.101361 . PMC   6838802 . PMID   31693977.
13. Carrara, Guia; Saraiva, Nuno; Parsons, Maddy; Byrne, Bernadette; Prole, David L.; Taylor, Colin W.; Smith, Geoffrey L. (2015-05-01). "Golgi Anti-apoptotic Proteins Are Highly Conserved Ion Channels That Affect Apoptosis and Cell Migration". Journal of Biological Chemistry. 290 (18): 11785–11801. doi: 10.1074/jbc.M115.637306 . ISSN   0021-9258. PMC   4416878 . PMID   25713081.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (August 2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Gubser C, Bergamaschi D, Hollinshead M, Lu X, van Kuppeveld FJ, Smith GL (February 2007). "A new inhibitor of apoptosis from vaccinia virus and eukaryotes". PLOS Pathogens. 3 (2): e17. doi: 10.1371/journal.ppat.0030017 . PMC   1803007 . PMID   17319741.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.