TMEM123

Last updated
TMEM123
Identifiers
Aliases TMEM123 , KCT3, PORIMIN, PORMIN, transmembrane protein 123
External IDs OMIM: 606356 MGI: 1919179 HomoloGene: 14177 GeneCards: TMEM123
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_052932

NM_133739

RefSeq (protein)

NP_443164

NP_598500

Location (UCSC) Chr 11: 102.4 – 102.47 Mb Chr 9: 7.76 – 7.79 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Porimin is a protein that in humans is encoded by the TMEM123 gene. [5] [6]

This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins.

Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis.

Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [6]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000152558 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050912 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ma F, Zhang C, Prasad KV, Freeman GJ, Schlossman SF (Aug 2001). "Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death". Proc Natl Acad Sci U S A. 98 (17): 9778–83. Bibcode:2001PNAS...98.9778M. doi: 10.1073/pnas.171322898 . PMC   55529 . PMID   11481458.
  6. 1 2 "Entrez Gene: TMEM123 transmembrane protein 123".

Further reading