TMEM165

TMEM165
Identifiers
Aliases	TMEM165 , CDG2K, FT27, GDT1, TMPT27, TPARL, transmembrane protein 165, SLC64A1, LCI
External IDs	OMIM: 614726; MGI: 894407; HomoloGene: 5411; GeneCards: TMEM165; OMA:TMEM165 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q12 Start 55,395,957 bp [1] End 55,453,397 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 C3.3|5 40.56 cM Start 76,331,727 bp [2] End 76,357,092 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum C1 segment gastric mucosa right lung inferior ganglion of vagus nerve upper lobe of left lung palpebral conjunctiva subthalamic nucleus cartilage tissue monocyte Top expressed in molar vestibular sensory epithelium mandibular prominence atrioventricular valve primitive streak endocardial cushion tail of embryo maxillary prominence vas deferens decidua More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 55858 21982 Ensembl ENSG00000134851 ENSMUSG00000029234 UniProt Q9HC07 P52875 RefSeq (mRNA) NM_018475 NM_011626 RefSeq (protein) NP_060945 NP_035756 Location (UCSC) Chr 4: 55.4 – 55.45 Mb Chr 5: 76.33 – 76.36 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transmembrane protein 165 is a protein that in humans is encoded by the TMEM165 gene. ^[5] It is found both on the Golgi and in lysosomes. It is also called LCI because it is a proton-activated, lysosomal calcium importer ^[6] .

References

1. GRCh38: Ensembl release 89: ENSG00000134851 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029234 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Transmembrane protein 165" . Retrieved 2011-12-06.
6. Zajac, M., Mukherjee, S., Anees, P., Oettinger, D., Henn, K., Srikumar, J., Zou, J. Saminathan, A., Krishnan, Y. A mechanism of lysosomal Calcium entry. Sci. Adv. 2024, 10, eadk2317. https://www.science.org/doi/10.1126/sciadv.adk2317

Further reading

• Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, et al. (August 2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 97 (17): 9543–9548. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.