TMEM51

TMEM51
Identifiers
Aliases	TMEM51 , C1orf72, transmembrane protein 51
External IDs	MGI: 2384874; HomoloGene: 9966; GeneCards: TMEM51; OMA:TMEM51 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p36.21 Start 15,152,532 bp [1] End 15,220,478 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D3 Start 141,758,303 bp [2] End 141,811,615 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas oocyte body of stomach cartilage tissue mucosa of transverse colon stromal cell of endometrium gallbladder buccal mucosa cell islet of Langerhans right adrenal cortex Top expressed in stomach right kidney proximal tubule ileum duodenum yolk sac jejunum human kidney urinary bladder colon More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding molecular function Cellular component membrane integral component of membrane cellular component Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55092 214359 Ensembl ENSG00000171729 ENSMUSG00000040616 UniProt Q9NW97 Q9BSA0 Q99LG1 RefSeq (mRNA) NM_001136216 NM_001136217 NM_001136218 NM_018022 NM_001319665 NM_145402 RefSeq (protein) NP_001129688 NP_001129689 NP_001129690 NP_001306594 NP_060492 NP_001306594.1 NP_663377 Location (UCSC) Chr 1: 15.15 – 15.22 Mb Chr 4: 141.76 – 141.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Pairwise Alignment of Human (Homo sapiens) TMEM51 and Zebrafish (Danio rerio) TMEM51 Amino Acid Sequences

Transmembrane protein 51 is a protein in humans that is encoded by the TMEM51 gene. ^[5] It is located on the first chromosome (1p36.21) and has 6 isoforms in humans. ^[6] It has orthologs in mammals, birds, reptiles, amphibians, and fish. ^[6]

It is predicted to be a transmembrane protein due to the transmembrane regions within its coding sequence. ^[7]

TMEM51-AS1 (a long non-coding RNA from the TMEM51 locus) acts as a tumor suppressor when overexpressed, inhibiting cancer cell progression. ^[8] Mutations or polymorphisms of the TMEM51 are associated susceptibility to Reynaud's syndrome. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000171729 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040616 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Transmembrane protein 51" . Retrieved 2012-10-29.
6. "AceView: Gene:TMEM51, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2025-09-29.
7. "Homo sapiens transmembrane protein 51 (TMEM51), transcript variant 1, mRNA". NCBI. 2025-04-27.
8. Wu D, Xia Q, Su X, Mao Y, Mao J, Ding Q, et al. (May 2025). "Long non-coding RNA TMEM51-AS1 inhibits colorectal cancer progression". Discover Oncology. 16 (1) 878. doi:10.1007/s12672-025-02676-z. PMC   12102048 . PMID   40407985.
9. Tervi A, Ramste M, Abner E, Cheng P, Lane JM, Maher M, et al. (September 2024). "Genetic and functional analysis of Raynaud's syndrome implicates loci in vasculature and immunity". Cell Genomics. 4 (9) 100630. doi:10.1016/j.xgen.2024.100630. PMC   11480858 . PMID   39142284.