TMEPAI

PMEPA1
Identifiers
Aliases	PMEPA1 , STAG1, TMEPAI, prostate transmembrane protein, androgen induced 1
External IDs	OMIM: 606564 MGI: 1929600 HomoloGene: 10608 GeneCards: PMEPA1
Gene location (Human)
Chr.	Chromosome 20 (human)
End	57,711,536 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	173,118,326 bp
RNA expression pattern
	Top expressed in
	visceral pleura; ; ascending aorta; ; popliteal artery; ; tibia; ; canal of the cervix; ; urethra; ; prostate; ; external globus pallidus; ; right coronary artery; ; parietal pleura;
	Top expressed in
	ascending aorta; ; aortic valve; ; external carotid artery; ; internal carotid artery; ; brown adipose tissue; ; subcutaneous adipose tissue; ; interventricular septum; ; white adipose tissue; ; sciatic nerve; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	WW domain binding ; R-SMAD binding ; protein binding ;
Cellular component	integral component of membrane ; Golgi membrane ; endosome ; plasma membrane ; Golgi apparatus ; early endosome membrane ; endosome membrane ; intracellular membrane-bounded organelle ; membrane ;
Biological process	androgen receptor signaling pathway ; negative regulation of signal transduction ; negative regulation of transforming growth factor beta receptor signaling pathway ; negative regulation of pathway-restricted SMAD protein phosphorylation ; negative regulation of SMAD protein complex assembly ;
	Sources:Amigo / QuickGO
Orthologs
	56937
	65112
	ENSG00000124225
	ENSMUSG00000038400
	Q969W9
	Q9D7R2
	NM_199171 ; NM_001255976 ; NM_020182 ; NM_199169 ; NM_199170 Contents Interactions ; References ; Further reading ;
	NM_022995
	NP_001242905 ; NP_064567 ; NP_954638 ; NP_954639 ; NP_954640
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 08, 2023

Transmembrane prostate androgen-induced protein is a protein that in humans is encoded by the PMEPA1 gene.^[5]^[6]

Interactions

TMEPAI has been shown to interact with NEDD4.^[7]

Related Research Articles

<span class="mw-page-title-main">Androgen receptor</span> Mammalian protein found in humans

The androgen receptor (AR), also known as NR3C4, is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone, in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor.

Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene.

SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene. SHC has been found to be important in the regulation of apoptosis and drug resistance in mammalian cells.

E3 ubiquitin-protein ligase NEDD4, also known as neural precursor cell expressed developmentally down-regulated protein 4 is an enzyme that is, in humans, encoded by the NEDD4 gene.

Four and a half LIM domains protein 2 also known as FHL-2 is a protein that in humans is encoded by the FHL2 gene. LIM proteins contain a highly conserved double zinc finger motif called the LIM domain.

Homeobox protein Nkx-3.1, also known as NKX3-1, NKX3, BAPX2, NKX3A and NKX3.1 is a protein that in humans is encoded by the NKX3-1 gene located on chromosome 8p. NKX3-1 is a prostatic tumor suppressor gene.

Probable G-protein coupled receptor 158 (GPR158), also known as the metabotropic glycine receptor (mGlyR), is a protein that in humans is encoded by the GPR158 gene.

Protein NDRG1 is a protein that in humans is encoded by the NDRG1 gene.

ERG is an oncogene. ERG is a member of the ETS family of transcription factors. The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator. Genes in the ETS family regulate embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis.

Glia-activating factor is a protein that in humans is encoded by the FGF9 gene.

40S ribosomal protein S16' is a protein that in humans is encoded by the RPS16 gene.

Transmembrane protease, serine 2 is an enzyme that in humans is encoded by the TMPRSS2 gene. It belongs to the TMPRSS family of proteins, whose members are transmembrane proteins which have a serine protease activity. The TMPRSS2 protein is found in high concentration in the cell membranes of epithelial cells of the lung and of the prostate, but also in the heart, liver and gastrointestinal tract.

SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEF gene.

Prostasin is a protein that in humans is encoded by the PRSS8 gene.

E3 ubiquitin-protein ligase RNF14 is an enzyme that in humans is encoded by the RNF14 gene.

Olfactory receptor 51E2 is a protein that in humans is encoded by the OR51E2 gene.

Melanoma-associated antigen 11 is a protein that in humans is encoded by the MAGEA11 gene. It is also involved in the androgen and progesterone receptor signaling pathways.

F-box-like/WD repeat-containing protein TBL1XR1 is a protein that in humans is encoded by the TBL1XR1 gene. The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins that appear to have a regulatory function. It is believed that the WD40 repeats mediate protein–protein interactions, and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation.

Solute carrier family 45 member 3 (SLC45A3), also known as prostate cancer-associated protein 6 or prostein, is a protein that in humans is encoded by the SLC45A3 gene.

Zinc transporter ZIP9, also known as Zrt- and Irt-like protein 9 (ZIP9) and solute carrier family 39 member 9, is a protein that in humans is encoded by the SLC39A9 gene. This protein is the 9th member out of 14 ZIP family proteins, which is a membrane androgen receptor (mAR) coupled to G proteins, and also classified as a zinc transporter protein. ZIP family proteins transport zinc metal from the extracellular environment into cells through cell membrane.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124225 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038400 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Xu LL, Shanmugam N, Segawa T, Sesterhenn IA, McLeod DG, Moul JW, Srivastava S (Jun 2000). "A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate". Genomics. 66 (3): 257–63. doi:10.1006/geno.2000.6214. PMID 10873380.
↑ "Entrez Gene: TMEPAI transmembrane, prostate androgen induced RNA".
↑ Xu LL, Shi Y, Petrovics G, Sun C, Makarem M, Zhang W, Sesterhenn IA, McLeod DG, Sun L, Moul JW, Srivastava S (Aug 2003). "PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression". Cancer Research. 63 (15): 4299–304. PMID 12907594.

Jolliffe CN, Harvey KF, Haines BP, Parasivam G, Kumar S (Nov 2000). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". The Biochemical Journal. 351 Pt 3 (3): 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394 . PMID 11042109.
Rae FK, Hooper JD, Nicol DL, Clements JA (Sep 2001). "Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors". Molecular Carcinogenesis. 32 (1): 44–53. doi: 10.1002/mc.1063 . PMID 11568975. S2CID 46602128.
Brunschwig EB, Wilson K, Mack D, Dawson D, Lawrence E, Willson JK, Lu S, Nosrati A, Rerko RM, Swinler S, Beard L, Lutterbaugh JD, Willis J, Platzer P, Markowitz S (Apr 2003). "PMEPA1, a transforming growth factor-beta-induced marker of terminal colonocyte differentiation whose expression is maintained in primary and metastatic colon cancer". Cancer Research. 63 (7): 1568–75. PMID 12670906.
Xu LL, Shi Y, Petrovics G, Sun C, Makarem M, Zhang W, Sesterhenn IA, McLeod DG, Sun L, Moul JW, Srivastava S (Aug 2003). "PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression". Cancer Research. 63 (15): 4299–304. PMID 12907594.
Giannini G, Ambrosini MI, Di Marcotullio L, Cerignoli F, Zani M, MacKay AR, Screpanti I, Frati L, Gulino A (Dec 2003). "EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a conserved gene family and is overexpressed and amplified in breast and ovarian cancer". Molecular Carcinogenesis. 38 (4): 188–200. doi:10.1002/mc.10162. PMID 14639658. S2CID 22894125.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569. S2CID 13709685.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124225 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038400 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10873380-5] Xu LL, Shanmugam N, Segawa T, Sesterhenn IA, McLeod DG, Moul JW, Srivastava S (Jun 2000). "A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate". Genomics. 66 (3): 257–63. doi:10.1006/geno.2000.6214. PMID 10873380.

[entrez-6] "Entrez Gene: TMEPAI transmembrane, prostate androgen induced RNA".

[pmid12907594-7] Xu LL, Shi Y, Petrovics G, Sun C, Makarem M, Zhang W, Sesterhenn IA, McLeod DG, Sun L, Moul JW, Srivastava S (Aug 2003). "PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression". Cancer Research. 63 (15): 4299–304. PMID 12907594.

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TMEPAI

Contents

Interactions

Related Research Articles

References

Further reading