TMEPAI

PMEPA1
Identifiers
Aliases	PMEPA1 , STAG1, TMEPAI, prostate transmembrane protein, androgen induced 1
External IDs	OMIM: 606564; MGI: 1929600; HomoloGene: 10608; GeneCards: PMEPA1; OMA:PMEPA1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.31 Start 57,648,392 bp [1] End 57,711,536 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H3 Start 173,066,251 bp [2] End 173,118,326 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in visceral pleura ascending aorta Descending thoracic aorta popliteal artery tibial arteries tibia tendon of biceps brachii canal of the cervix urethra prostate Top expressed in ascending aorta aortic valve external carotid artery internal carotid artery tunica media of zone of aorta brown adipose tissue subcutaneous adipose tissue interventricular septum white adipose tissue sciatic nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function WW domain binding R-SMAD binding protein binding Cellular component integral component of membrane Golgi membrane endosome plasma membrane Golgi apparatus early endosome membrane endosome membrane intracellular membrane-bounded organelle membrane Biological process androgen receptor signaling pathway negative regulation of signal transduction negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of pathway-restricted SMAD protein phosphorylation negative regulation of SMAD protein complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56937 65112 Ensembl ENSG00000124225 ENSMUSG00000038400 UniProt Q969W9 Q9D7R2 RefSeq (mRNA) NM_199171 NM_001255976 NM_020182 NM_199169 NM_199170 NM_022995 RefSeq (protein) NP_001242905 NP_064567 NP_954638 NP_954639 NP_954640 n/a Location (UCSC) Chr 20: 57.65 – 57.71 Mb Chr 2: 173.07 – 173.12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transmembrane prostate androgen-induced protein is a protein that in humans is encoded by the PMEPA1 gene. ^{[5] [6]}

Interactions

TMEPAI has been shown to interact with NEDD4. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000124225 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038400 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xu LL, Shanmugam N, Segawa T, Sesterhenn IA, McLeod DG, Moul JW, Srivastava S (Jun 2000). "A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate". Genomics. 66 (3): 257–63. doi:10.1006/geno.2000.6214. PMID   10873380.
6. "Entrez Gene: TMEPAI transmembrane, prostate androgen induced RNA".
7. Xu LL, Shi Y, Petrovics G, Sun C, Makarem M, Zhang W, Sesterhenn IA, McLeod DG, Sun L, Moul JW, Srivastava S (Aug 2003). "PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression". Cancer Research. 63 (15): 4299–304. PMID   12907594.

Further reading

• Jolliffe CN, Harvey KF, Haines BP, Parasivam G, Kumar S (Nov 2000). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". The Biochemical Journal. 351 Pt 3 (3): 557–65. doi:10.1042/0264-6021:3510557. PMC   1221394 . PMID   11042109.
• Rae FK, Hooper JD, Nicol DL, Clements JA (Sep 2001). "Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors". Molecular Carcinogenesis. 32 (1): 44–53. doi: 10.1002/mc.1063 . PMID   11568975. S2CID   46602128.
• Brunschwig EB, Wilson K, Mack D, Dawson D, Lawrence E, Willson JK, Lu S, Nosrati A, Rerko RM, Swinler S, Beard L, Lutterbaugh JD, Willis J, Platzer P, Markowitz S (Apr 2003). "PMEPA1, a transforming growth factor-beta-induced marker of terminal colonocyte differentiation whose expression is maintained in primary and metastatic colon cancer". Cancer Research. 63 (7): 1568–75. PMID   12670906.
• Xu LL, Shi Y, Petrovics G, Sun C, Makarem M, Zhang W, Sesterhenn IA, McLeod DG, Sun L, Moul JW, Srivastava S (Aug 2003). "PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression". Cancer Research. 63 (15): 4299–304. PMID   12907594.
• Giannini G, Ambrosini MI, Di Marcotullio L, Cerignoli F, Zani M, MacKay AR, Screpanti I, Frati L, Gulino A (Dec 2003). "EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a conserved gene family and is overexpressed and amplified in breast and ovarian cancer". Molecular Carcinogenesis. 38 (4): 188–200. doi:10.1002/mc.10162. PMID   14639658. S2CID   22894125.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.