TMF1

TMF1
Identifiers
Aliases	TMF1 , ARA160, TMF, TATA element modulatory factor 1
External IDs	OMIM: 601126; MGI: 2684999; HomoloGene: 133801; GeneCards: TMF1; OMA:TMF1 - orthologs
Gene location (Mouse) Chr. Chromosome 6 (mouse) [1] Band 6|6 D3 Start 97,129,958 bp [1] End 97,156,083 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon stromal cell of endometrium caput epididymis islet of Langerhans bronchial epithelial cell right uterine tube corpus epididymis rectum body of pancreas minor salivary glands Top expressed in spermatid otolith organ spermatocyte utricle zygote iris tail of embryo genital tubercle secondary oocyte ciliary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription coregulator activity protein binding Cellular component cytoplasm Golgi apparatus membrane Golgi membrane endoplasmic reticulum nucleus cytosol Biological process flagellated sperm motility regulation of proteasomal protein catabolic process male gonad development regulation of transcription, DNA-templated Leydig cell differentiation positive regulation of cytokine production cellular response to organic cyclic compound negative regulation of apoptotic process transcription by RNA polymerase II negative regulation of gene expression transcription, DNA-templated positive regulation of testosterone secretion defense response to bacterium acrosome assembly spermatid development luteinizing hormone secretion spermatid nucleus differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7110 232286 Ensembl n/a ENSMUSG00000030059 UniProt P82094 Q6PII6 B9EKI3 RefSeq (mRNA) NM_007114 NM_001363879 NM_001081111 RefSeq (protein) NP_009045 NP_001350808 NP_009045.2 NP_001074580 Location (UCSC) n/a Chr 6: 97.13 – 97.16 Mb PubMed search [2] [3]
Wikidata
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TATA element modulatory factor is a protein that in humans is encoded by the TMF1 gene. ^{[4] [5]}

Interactions

TMF1 has been shown to interact with FER ^[6] and Androgen receptor. ^[7]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000030059 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Garcia JA, Ou SH, Wu F, Lusis AJ, Sparkes RS, Gaynor RB (Nov 1992). "Cloning and chromosomal mapping of a human immunodeficiency virus 1 "TATA" element modulatory factor". Proc Natl Acad Sci U S A. 89 (20): 9372–6. Bibcode:1992PNAS...89.9372G. doi: 10.1073/pnas.89.20.9372 . PMC   50133 . PMID   1409643.
5. "Entrez Gene: TMF1 TATA element modulatory factor 1".
6. Schwartz, Y; Ben-Dor I; Navon A; Motro B; Nir U (Sep 1998). "Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases". FEBS Lett. 434 (3): 339–45. Bibcode:1998FEBSL.434..339S. doi:10.1016/S0014-5793(98)01003-5. ISSN   0014-5793. PMID   9742951. S2CID   24338520.
7. Hsiao, P W; Chang C (Aug 1999). "Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells". J. Biol. Chem. 274 (32): 22373–9. doi: 10.1074/jbc.274.32.22373 . ISSN   0021-9258. PMID   10428808.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Schwartz Y, Ben-Dor I, Navon A, et al. (1998). "Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases". FEBS Lett. 434 (3): 339–45. Bibcode:1998FEBSL.434..339S. doi:10.1016/S0014-5793(98)01003-5. PMID   9742951. S2CID   24338520.
• Hsiao PW, Chang C (1999). "Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells". J. Biol. Chem. 274 (32): 22373–9. doi: 10.1074/jbc.274.32.22373 . PMID   10428808.
• Mori K, Kato H (2002). "A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus". FEBS Lett. 520 (1–3): 127–32. Bibcode:2002FEBSL.520..127M. doi:10.1016/S0014-5793(02)02803-X. PMID   12044884. S2CID   84784473.
• Zhang Y, Fondell JD, Wang Q, et al. (2002). "Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1". Oncogene. 21 (36): 5609–18. doi:10.1038/sj.onc.1205638. PMID   12165860. S2CID   22209143.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Fridmann-Sirkis Y, Siniossoglou S, Pelham HR (2004). "TMF is a golgin that binds Rab6 and influences Golgi morphology". BMC Cell Biol. 5: 18. doi: 10.1186/1471-2121-5-18 . PMC   419336 . PMID   15128430.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Yamane J, Kubo A, Nakayama K, et al. (2007). "Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic" (PDF). Exp. Cell Res. 313 (16): 3472–85. doi:10.1016/j.yexcr.2007.07.010. hdl: 2433/135781 . PMID   17698061.