TMIGD1

Last updated
TMIGD1
Identifiers
Aliases TMIGD1 , TMIGD, UNQ9372, transmembrane and immunoglobulin domain containing 1
External IDs MGI: 1913851 HomoloGene: 41641 GeneCards: TMIGD1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_206832
NM_001319942

NM_025655
NM_001382246
NM_001382247

RefSeq (protein)

NP_001306871
NP_996663

NP_079931
NP_001369175
NP_001369176

Location (UCSC) Chr 17: 30.32 – 30.33 Mb Chr 11: 76.79 – 76.81 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transmembrane and immunoglobulin domain containing 1 is a protein that in humans is encoded by the TMIGD1 gene. [5] TMIGD1 was discovered by the lab of Giancarlo Marra [6] and later cloned by Nader Rahimi. [7] [8] . Recent findings suggest functions in brush border formation (intestinal epithelium) and roles as tumor suppressor (kidney and intestine) [9] .

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000182271 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020839 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Transmembrane and immunoglobulin domain containing 1" . Retrieved 2017-02-20.
  6. Cattaneo E, Laczko E, Buffoli F, Zorzi F, Bianco MA, Menigatti M, et al. (May 2011). "Preinvasive colorectal lesion transcriptomes correlate with endoscopic morphology (polypoid vs. nonpolypoid)". EMBO Mol Med. 3 (6): 334–347. doi:10.1002/emmm.201100141. PMC   5839393 . PMID   3377079.
  7. Meyer RD, Zou X, Ali M, Ersoy E, Bondzie PA, Lavaei M, et al. (February 2018). "TMIGD1 acts as a tumor suppressor through regulation of p21Cip1/p27Kip1 in renal cancer". Oncotarget. 9 (11): 9672–9684. doi:10.18632/oncotarget.23822. PMC   5839393 . PMID   29515762.
  8. Arafa E, Bondzie PA, Rezazadeh K, Meyer RD, Hartsough E, Henderson JM, et al. (October 2015). "TMIGD1 is a novel adhesion molecule that protects epithelial cells from oxidative cell injury". The American Journal of Pathology. 185 (10): 2757–67. doi:10.1016/j.ajpath.2015.06.006. PMC   4607757 . PMID   26342724.
  9. Thuering E, et al. (April 2023). "TMIGD1: Emerging functions of a tumor suppressor and adhesion receptor". Oncogene. 42 (22): 1777–1785. doi:10.1038/s41388-023-02696-5. PMC   10238269 . PMID   37087524.