TMIGD1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | TMIGD1 , TMIGD, UNQ9372, transmembrane and immunoglobulin domain containing 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI: 1913851 HomoloGene: 41641 GeneCards: TMIGD1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Transmembrane and immunoglobulin domain containing 1 is a protein that in humans is encoded by the TMIGD1 gene. [5] TMIGD1 was discovered by the lab of Giancarlo Marra [6] and later cloned by Nader Rahimi. [7] [8] . Recent findings suggest functions in brush border formation (intestinal epithelium) and roles as tumor suppressor (kidney and intestine) [9] .
Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
Adhesion G-protein coupled receptor A3 (ADGRA3), also known as GPR125, is an adhesion GPCR that in humans is encoded by the Adgra3 gene.
EGF, latrophilin and seven transmembrane domain-containing protein 1 is a latrophilin-like orphan receptor of the adhesion G protein-coupled receptor family. In humans this protein is encoded by the ELTD1 gene. ELTD1 appears to have a role in angiogenesis, both physiological and pathological in cancer.
Cell adhesion molecule 1 is a protein that, in humans, is encoded by the CADM1 gene.
CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene. It is also called CD166, MEMD, SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat.
Opioid-binding protein/cell adhesion molecule is a protein that in humans is encoded by the OPCML gene.
Epithelial membrane protein 3 (EMP3) is a trans-membrane signaling molecule that is encoded by the myelin-related gene EMP3. EMP3 is a member of the peripheral myelin protein gene family 22-kDa (PMP22), which is mainly responsible for the formation of the sheath of compact myelin. Although the detailed functions and mechanisms of EMP3 still remain unclear, it is suggested that EMP3 is possibly epigenetically linked to certain carcinomas.
Cell adhesion molecule 3 is a protein that in humans is encoded by the CADM3 gene.
Netrin receptor UNC5C is a protein that in humans is encoded by the UNC5C gene.
Endothelial cell-selective adhesion molecule is a protein that in humans is encoded by the ESAM gene.
Neurotrimin is a protein that in humans is encoded by the NTM gene.
Immunoglobulin superfamily, member 2 (IGSF2) also known as CD101, is a human gene.
Transmembrane protein 158 is a protein that in humans is encoded by the TMEM158 gene.
Protocadherin gamma-A11 is a protein that in humans is encoded by the PCDHGA11 gene.
Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.
CD96 or Tactile is a protein that in humans is encoded by the CD96 gene. CD96 is a receptor protein which is expressed on T cells and NK cells and shares sequence similarity with CD226. The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesion of activated T and NK cells to their target cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. CD96 is a transmembrane glycoprotein that has three extracellular immunoglobulin-like domains and is expressed by all resting human and mouse NK cells. CD96 main ligand is CD155. CD 96 has approximately 20% homology with CD226 and competed for binding to CD155 with CD226.
Gene HEPACAM*, named based on its original site of identification - hepatocytes and the nature of its protein product - a cell adhesion molecule (CAM), was first discovered and characterised in human liver and reported by Shali Shen in 2005. The gene encodes a protein of 416 amino acids, designated as hepaCAM**, which is a new member of the immunoglobulin superfamily of cell adhesion molecules. The main biological functions of hepaCAM include a) modulating cell-matrix adhesion and migration, and b) inhibiting cancer cell growth.
Transmembrane and immunoglobulin domain containing 2 is a protein that in humans is encoded by the TMIGD2 gene. TMIGD2 was discovered by Nader Rahimi.
V-domain Ig suppressor of T cell activation (VISTA) is a type I transmembrane protein that functions as an immune checkpoint and is encoded by the C10orf54 gene.
Heat Shock Protein Family B (small) member 7 (HSPB7) in humans is a protein encoded by a gene of the same name with four exons that is located on chromosome 1p36.13.,. HSPB7 contains 170 amino acids and has a molecular weight of 18,611Da. HSPB7 is a member of human small heat shock protein (HSPB) family, which contains eleven family members of chaperone proteins. HSPB7 and its gene pair SRARP are located 5 kb apart on the opposite strands of chromosome 1p36.13.