TNFAIP8

TNFAIP8
Identifiers
Aliases	TNFAIP8 , GG2-1, MDC-3.13, NDED, SCC-S2, SCCS2, TNF alpha induced protein 8
External IDs	OMIM: 612111; MGI: 2147191; HomoloGene: 8649; GeneCards: TNFAIP8; OMA:TNFAIP8 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q23.1 Start 119,268,692 bp [1] End 119,399,688 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 D1 Start 50,112,494 bp [2] End 50,240,240 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue epithelium of nasopharynx appendix bone marrow white blood cell mononuclear cell monocyte lymph node bone marrow cells trabecular bone Top expressed in gastrula right kidney granulocyte decidua thymus human kidney primary oocyte spleen conjunctival fornix myocardium of ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cysteine-type endopeptidase inhibitor activity involved in apoptotic process protein binding Cellular component cytoplasm nucleoplasm Biological process negative regulation of apoptotic process apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of apoptotic process regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25816 106869 Ensembl ENSG00000145779 ENSMUSG00000062210 UniProt O95379 Q921Z5 RefSeq (mRNA) NM_014350 NM_001077654 NM_001286813 NM_001286814 NM_001286815 NM_001286817 NM_001177759 NM_001177760 NM_134131 NM_001360935 RefSeq (protein) NP_001071122 NP_001273742 NP_001273743 NP_001273744 NP_001273746 NP_055165 NP_001171230 NP_001171231 NP_598892 NP_001347864 Location (UCSC) Chr 5: 119.27 – 119.4 Mb Chr 18: 50.11 – 50.24 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tumor necrosis factor, alpha-induced protein 8 is a protein that in humans is encoded by the TNFAIP8 gene. ^{[5] [6] [7]} It is preferentially expressed in human immune cell types. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000145779 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062210 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Horrevoets AJ, Fontijn RD, van Zonneveld AJ, de Vries CJ, ten Cate JW, Pannekoek H (Jun 1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes". Blood. 93 (10): 3418–31. doi:10.1182/blood.V93.10.3418.410k23_3418_3431. PMID   10233894.
6. Kumar D, Whiteside TL, Kasid U (Feb 2000). "Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin- 1beta-converting enzyme-inhibitory protein". J Biol Chem. 275 (4): 2973–8. doi: 10.1074/jbc.275.4.2973 . PMID   10644768.
7. "Entrez Gene: TNFAIP8 tumor necrosis factor, alpha-induced protein 8".
8. Li T, Wang W, et al. (May 2018). "Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism". Molecular Immunology. 99: 154–162. doi:10.1016/j.molimm.2018.05.007. PMC   5995464 . PMID   29787979.

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Kumar D, Gokhale P, Broustas C, et al. (2004). "Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells". Oncogene. 23 (2): 612–6. doi: 10.1038/sj.onc.1207123 . PMID   14724590.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.