TNIP2

TNIP2
Identifiers
Aliases	TNIP2 , ABIN2, FLIP1, KLIP, TNFAIP3 interacting protein 2
External IDs	OMIM: 610669; MGI: 2386643; HomoloGene: 11515; GeneCards: TNIP2; OMA:TNIP2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4p16.3 Start 2,741,648 bp [1] End 2,756,342 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 B2 Start 34,653,431 bp [2] End 34,671,335 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii pancreatic ductal cell granulocyte mucosa of transverse colon apex of heart gastric mucosa muscle layer of sigmoid colon body of stomach upper lobe of left lung monocyte Top expressed in neural layer of retina interventricular septum granulocyte lip right kidney primary visual cortex muscle of thigh superior frontal gyrus dentate gyrus of hippocampal formation granule cell esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase binding metal ion binding polyubiquitin modification-dependent protein binding K63-linked polyubiquitin modification-dependent protein binding Cellular component nucleus cytosol cytoplasm nucleoplasm Biological process negative regulation of endothelial cell apoptotic process regulation of transcription, DNA-templated CD40 signaling pathway protein stabilization positive regulation of macrophage activation transcription, DNA-templated stress-activated MAPK cascade positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of B cell activation inflammatory response I-kappaB kinase/NF-kappaB signaling positive regulation of transcription by RNA polymerase II apoptotic process toll-like receptor 9 signaling pathway toll-like receptor 2 signaling pathway toll-like receptor 3 signaling pathway protein deubiquitination cellular response to lipopolysaccharide interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79155 231130 Ensembl ENSG00000168884 ENSMUSG00000059866 UniProt Q8NFZ5 Q99JG7 RefSeq (mRNA) NM_024309 NM_001161527 NM_001292016 NM_139064 RefSeq (protein) NP_001154999 NP_001278945 NP_077285 NP_620703 Location (UCSC) Chr 4: 2.74 – 2.76 Mb Chr 5: 34.65 – 34.67 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

TNFAIP3-interacting protein 2 is a protein that in humans is encoded by the TNIP2 gene. ^{[5] [6] [7]} TNIP2 contains multiple amino acid sites that are phosphorylated and ubiquitinated. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000168884 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059866 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Van Huffel S, Delaei F, Heyninck K, De Valck D, Beyaert R (Aug 2001). "Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2". J Biol Chem. 276 (32): 30216–23. doi: 10.1074/jbc.M100048200 . PMID   11390377.
6. Tadros A, Hughes DP, Dunmore BJ, Brindle NP (Dec 2003). "ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1". Blood. 102 (13): 4407–9. doi: 10.1182/blood-2003-05-1602 . PMID   12933576.
7. "Entrez Gene: TNIP2 TNFAIP3 interacting protein 2".
8. "TNIP2 (human)". www.phosphosite.org. Retrieved 2020-10-31.

Further reading

• Heyninck K, De Valck D, Vanden Berghe W, et al. (1999). "The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN". J. Cell Biol. 145 (7): 1471–82. doi:10.1083/jcb.145.7.1471. hdl:1854/LU-113881. PMC   2133159 . PMID   10385526.
• Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R (2001). "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions". FEBS Lett. 498 (1): 93–7. doi:10.1016/S0014-5793(01)02504-2. PMID   11389905. S2CID   32414520.
• Wu WS, Xu ZX, Chang KS (2002). "The promyelocytic leukemia protein represses A20-mediated transcription". J. Biol. Chem. 277 (35): 31734–9. doi: 10.1074/jbc.M201648200 . PMID   12080044.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Liu WK, Chien CY, Chou CK, Su JY (2003). "An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation". J. Biomed. Sci. 10 (2): 242–52. doi:10.1159/000068708. PMID   12595760. S2CID   202644741.
• Hughes DP, Marron MB, Brindle NP (2003). "The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2". Circ. Res. 92 (6): 630–6. doi: 10.1161/01.RES.0000063422.38690.DC . hdl: 2381/866 . PMID   12609966.
• Chien CY, Liu WK, Chou CK, Su JY (2003). "The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation". FEBS Lett. 543 (1–3): 55–60. doi: 10.1016/S0014-5793(03)00401-0 . PMID   12753905. S2CID   31400521.
• Liu WK, Yen PF, Chien CY, et al. (2004). "The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis". Biochem. J. 378 (Pt 3): 867–76. doi:10.1042/BJ20031736. PMC   1224013 . PMID   14653779.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Lang V, Symons A, Watton SJ, et al. (2004). "ABIN-2 Forms a Ternary Complex with TPL-2 and NF-κB1 p105 and Is Essential for TPL-2 Protein Stability". Mol. Cell. Biol. 24 (12): 5235–48. doi:10.1128/MCB.24.12.5235-5248.2004. PMC   419892 . PMID   15169888.
• Li CC, Chou CK, Wang MH, Tsai TF (2006). "Overexpression of ABIN-2, a negative regulator of NF-kappaB, delays liver regeneration in the ABIN-2 transgenic mice". Biochem. Biophys. Res. Commun. 342 (1): 300–9. doi:10.1016/j.bbrc.2006.01.114. PMID   16480954.
• Greenberg H, Ye X, Wilson D, et al. (2006). "Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo". Biochem. Biophys. Res. Commun. 343 (2): 591–6. doi:10.1016/j.bbrc.2006.03.015. PMID   16554025.
• Liu Y, Nakahara T, Miyakoshi J, et al. (2007). "Nuclear accumulation and activation of nuclear factor kappaB after split-dose irradiation in LS174T cells". J. Radiat. Res. 48 (1): 13–20. Bibcode:2007JRadR..48...13L. doi: 10.1269/jrr.0615 . PMID   17038805.