TNRC15

GIGYF2
Identifiers
Aliases	GIGYF2 , GYF2, PARK11, PERQ2, PERQ3, TNRC15, GRB10 interacting GYF protein 2
External IDs	OMIM: 612003 MGI: 2138584 HomoloGene: 41048 GeneCards: GIGYF2
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q37.1 Start 232,697,299 bp [1] End 232,860,605 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 C5- D Start 87,254,720 bp [2] End 87,378,518 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sural nerve corpus callosum islet of Langerhans bone marrow cells gastrocnemius muscle body of pancreas ganglionic eminence skin of abdomen thymus Top expressed in yolk sac spermatocyte superior frontal gyrus morula spermatid cerebellar cortex secondary oocyte medullary collecting duct ganglionic eminence thymus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding proline-rich region binding RNA binding cadherin binding Cellular component membrane cytoplasm endosome endoplasmic reticulum Golgi apparatus cytosol cytoplasmic stress granule integral component of membrane vesicle perikaryon proximal dendrite protein-containing complex Biological process adult locomotory behavior homeostasis of number of cells within a tissue negative regulation of translation spinal cord motor neuron differentiation post-embryonic development mitotic G1 DNA damage checkpoint signaling feeding behavior musculoskeletal movement multicellular organism growth neuromuscular process controlling balance posttranscriptional gene silencing insulin-like growth factor receptor signaling pathway mRNA destabilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26058 227331 Ensembl ENSG00000204120 ENSMUSG00000048000 UniProt Q6Y7W6 Q6Y7W8 RefSeq (mRNA) NM_001103146 NM_001103147 NM_001103148 NM_015575 NM_001110212 NM_146112 RefSeq (protein) NP_001096616 NP_001096617 NP_001096618 NP_056390 NP_001103682 NP_666224 Location (UCSC) Chr 2: 232.7 – 232.86 Mb Chr 1: 87.25 – 87.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

PERQ amino acid-rich with GYF domain-containing protein 2 is a protein that in humans is encoded by the GIGYF2 gene. ^{[5] [6] [7] [8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000204120 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048000 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114–22. doi:10.1007/s004390050476. PMID   9225980. S2CID   25999127.
6. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID   9734811.
7. Giovannone B, Lee E, Laviola L, Giorgino F, Cleveland KA, Smith RJ (Aug 2003). "Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling". J Biol Chem. 278 (34): 31564–73. doi: 10.1074/jbc.M211572200 . PMID   12771153.
8. Lautier C, Goldwurm S, Durr A, Giovannone B, Tsiaras WG, Pezzoli G, Brice A, Smith RJ (Apr 2008). "Mutations in the GIGYF2 (TNRC15) Gene at the PARK11 Locus in Familial Parkinson Disease". Am J Hum Genet. 82 (4): 822–33. doi:10.1016/j.ajhg.2008.01.015. PMC   2427211 . PMID   18358451.
9. "Entrez Gene: TNRC15 trinucleotide repeat containing 15".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID   8889549.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kofler M, Motzny K, Freund C (2006). "GYF domain proteomics reveals interaction sites in known and novel target proteins". Mol. Cell. Proteomics. 4 (11): 1797–811. doi: 10.1074/mcp.M500129-MCP200 . PMID   16120600.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.