TNS4

TNS4
Identifiers
Aliases	TNS4 , CTEN, PP14434, tensin 4
External IDs	OMIM: 608385 MGI: 2144377 HomoloGene: 13147 GeneCards: TNS4
Gene location (Human)
Chr.	Chromosome 17 (human)
End	40,501,623 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,980,132 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; minor salivary gland; ; lactiferous duct; ; nipple; ; vagina; ; thymus; ; cavity of mouth; ; prostate; ; vulva; ; placenta;
	Top expressed in
	left colon; ; lip; ; Paneth cell; ; cornea; ; epidermis; ; esophagus; ; hair follicle; ; skin of abdomen; ; skin of back; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding ; protein binding ;
Cellular component	cytoplasm ; cell junction ; cytoskeleton ; focal adhesion ; cytosol ;
Biological process	protein localization ; apoptotic process ;
	Sources:Amigo / QuickGO
Orthologs
	84951
	217169
	ENSG00000131746
	ENSMUSG00000017607
	Q8IZW8
	Q8BZ33
	NM_032865
	NM_172564
	NP_116254
	NP_766152
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 17, 2023

Tensin-4 is a protein that in humans is encoded by the TNS4 gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131746 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017607 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lo SH, Lo TB (Aug 2002). "Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer". Cancer Res. 62 (15): 4217–21. PMID 12154022.
↑ Sasaki H, Moriyama S, Mizuno K, Yukiue H, Konishi A, Yano M, Kaji M, Fukai I, Kiriyama M, Yamakawa Y, Fujii Y (Apr 2003). "Cten mRNA expression was correlated with tumor progression in lung cancers". Lung Cancer. 40 (2): 151–5. doi:10.1016/S0169-5002(03)00037-0. PMID 12711115.
↑ "Entrez Gene: TNS4 tensin 4".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC 16267 . PMID 10737800.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Sasaki H, Yukiue H, Kobayashi Y, et al. (2004). "Cten mRNA expression is correlated with tumor progression in thymoma". Tumour Biol. 24 (5): 271–4. doi:10.1159/000076141. PMID 15001839. S2CID 46751099.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC 524842 . PMID 15498874.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi: 10.1074/mcp.M500021-MCP200 . PMID 15778465.
Lo SS, Lo SH, Lo SH (2005). "Cleavage of cten by caspase-3 during apoptosis". Oncogene. 24 (26): 4311–4. doi: 10.1038/sj.onc.1208571 . PMID 15806167.
Liao YC, Si L, deVere White RW, Lo SH (2007). "The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1". J. Cell Biol. 176 (1): 43–9. doi:10.1083/jcb.200608015. PMC 2063623 . PMID 17190795.
Katz M, Amit I, Citri A, et al. (2007). "A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration". Nat. Cell Biol. 9 (8): 961–9. doi:10.1038/ncb1622. PMID 17643115. S2CID 27088360.
Mouneimne G, Brugge JS (2007). "Tensins: a new switch in cell migration". Dev. Cell. 13 (3): 317–9. doi: 10.1016/j.devcel.2007.08.010 . PMID 17765673.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000131746 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017607 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12154022-5] Lo SH, Lo TB (Aug 2002). "Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer". Cancer Res. 62 (15): 4217–21. PMID 12154022.

[pmid12711115-6] Sasaki H, Moriyama S, Mizuno K, Yukiue H, Konishi A, Yano M, Kaji M, Fukai I, Kiriyama M, Yamakawa Y, Fujii Y (Apr 2003). "Cten mRNA expression was correlated with tumor progression in lung cancers". Lung Cancer. 40 (2): 151–5. doi:10.1016/S0169-5002(03)00037-0. PMID 12711115.

[entrez-7] "Entrez Gene: TNS4 tensin 4".

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TNS4

Related Research Articles

References

Further reading