TNS4

TNS4
Identifiers
Aliases	TNS4 , CTEN, PP14434, tensin 4
External IDs	OMIM: 608385; MGI: 2144377; HomoloGene: 13147; GeneCards: TNS4; OMA:TNS4 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.2 Start 40,475,828 bp [1] End 40,501,623 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 D Start 98,956,504 bp [2] End 98,980,132 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg minor salivary glands olfactory zone of nasal mucosa gingival epithelium mucosa of paranasal sinus lactiferous duct nipple vagina skin of thigh Top expressed in left colon lip skin of external ear transitional epithelium of urinary bladder Paneth cell cornea epidermis genital tubercle esophagus hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein binding Cellular component cytoplasm cell junction cytoskeleton focal adhesion cytosol Biological process protein localization apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84951 217169 Ensembl ENSG00000131746 ENSMUSG00000017607 UniProt Q8IZW8 Q8BZ33 RefSeq (mRNA) NM_032865 NM_172564 RefSeq (protein) NP_116254 NP_766152 Location (UCSC) Chr 17: 40.48 – 40.5 Mb Chr 11: 98.96 – 98.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tensin-4 is a protein that in humans is encoded by the TNS4 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000131746 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017607 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lo SH, Lo TB (Aug 2002). "Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer". Cancer Res. 62 (15): 4217–21. PMID   12154022.
6. Sasaki H, Moriyama S, Mizuno K, Yukiue H, Konishi A, Yano M, Kaji M, Fukai I, Kiriyama M, Yamakawa Y, Fujii Y (Apr 2003). "Cten mRNA expression was correlated with tumor progression in lung cancers". Lung Cancer. 40 (2): 151–5. doi:10.1016/S0169-5002(03)00037-0. PMID   12711115.
7. "Entrez Gene: TNS4 tensin 4".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Sasaki H, Yukiue H, Kobayashi Y, et al. (2004). "Cten mRNA expression is correlated with tumor progression in thymoma". Tumour Biol. 24 (5): 271–4. doi:10.1159/000076141. PMID   15001839. S2CID   46751099.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi: 10.1074/mcp.M500021-MCP200 . PMID   15778465.
• Lo SS, Lo SH, Lo SH (2005). "Cleavage of cten by caspase-3 during apoptosis". Oncogene. 24 (26): 4311–4. doi: 10.1038/sj.onc.1208571 . PMID   15806167.
• Liao YC, Si L, deVere White RW, Lo SH (2007). "The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1". J. Cell Biol. 176 (1): 43–9. doi:10.1083/jcb.200608015. PMC   2063623 . PMID   17190795.
• Katz M, Amit I, Citri A, et al. (2007). "A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration". Nat. Cell Biol. 9 (8): 961–9. doi:10.1038/ncb1622. PMID   17643115. S2CID   27088360.
• Mouneimne G, Brugge JS (2007). "Tensins: a new switch in cell migration". Dev. Cell. 13 (3): 317–9. doi: 10.1016/j.devcel.2007.08.010 . PMID   17765673.