TOB1

TOB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D5R, 2Z15, 5CI8, 5CI9
Identifiers
Aliases	TOB1 , APRO6, PIG49, TOB, TROB, TROB1, transducer of ERBB2, 1, APRO5
External IDs	OMIM: 605523 MGI: 1349721 HomoloGene: 31334 GeneCards: TOB1
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.33 Start 50,862,223 bp [1] End 50,867,978 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 D Start 94,102,280 bp [2] End 94,106,321 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium seminal vesicula trachea vastus lateralis muscle cardia human penis amniotic fluid urethra triceps brachii muscle jejunum Top expressed in extensor digitorum longus muscle plantaris muscle pineal gland submandibular gland parotid gland seminal vesicula intercostal muscle triceps brachii muscle digastric muscle sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function receptor tyrosine kinase binding SMAD binding protein binding transcription corepressor activity Cellular component CCR4-NOT complex cytoplasm nucleus Biological process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay negative regulation of osteoblast differentiation negative regulation of nuclear-transcribed mRNA poly(A) tail shortening negative regulation of nucleic acid-templated transcription negative regulation of BMP signaling pathway negative regulation of translation positive regulation of nuclear-transcribed mRNA poly(A) tail shortening BMP signaling pathway negative regulation of cell population proliferation positive regulation of signal transduction regulation of SMAD protein signal transduction regulation of gene expression Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10140 22057 Ensembl ENSG00000141232 ENSMUSG00000037573 UniProt P50616 Q61471 RefSeq (mRNA) NM_005749 NM_001243877 NM_001243885 NM_009427 RefSeq (protein) NP_001230806 NP_001230814 NP_005740 NP_033453 Location (UCSC) Chr 17: 50.86 – 50.87 Mb Chr 11: 94.1 – 94.11 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein Tob1 is a protein that in humans is encoded by the TOB1 gene. ^{[5] [6] [7]}

Function

This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein suppresses cell growth in tissue culture. The protein undergoes phosphorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells. ^[7]

Interactions

TOB1 has been shown to interact with:

• CNOT7, ^{[8] [9]}
• MAPK1 ^[10]
• MARCKS, ^[11]
• Mitogen-activated protein kinase 9, ^[10] and
• RPS6KA1. ^[12]

References

1. GRCh38: Ensembl release 89: ENSG00000141232 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037573 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Matsuda S, Kawamura-Tsuzuku J, Ohsugi M, Yoshida M, Emi M, Nakamura Y, Onda M, Yoshida Y, Nishiyama A, Yamamoto T (Feb 1996). "Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity". Oncogene. 12 (4): 705–13. PMID   8632892.
6. Ezzeddine N, Chang TC, Zhu W, Yamashita A, Chen CY, Zhong Z, Yamashita Y, Zheng D, Shyu AB (Nov 2007). "Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation". Molecular and Cellular Biology. 27 (22): 7791–801. doi:10.1128/MCB.01254-07. PMC   2169145 . PMID   17785442.
7. "Entrez Gene: TOB1 transducer of ERBB2, 1".
8. Funakoshi Y, Doi Y, Hosoda N, Uchida N, Osawa M, Shimada I, Tsujimoto M, Suzuki T, Katada T, Hoshino S (Dec 2007). "Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases". Genes & Development. 21 (23): 3135–48. doi:10.1101/gad.1597707. PMC   2081979 . PMID   18056425.
9. Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (Dec 1999). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene. 18 (52): 7432–41. doi:10.1038/sj.onc.1203193. PMID   10602502. S2CID   35769674.
10. Maekawa M, Nishida E, Tanoue T (Oct 2002). "Identification of the Anti-proliferative protein Tob as a MAPK substrate". The Journal of Biological Chemistry. 277 (40): 37783–7. doi: 10.1074/jbc.M204506200 . PMID   12151396.
11. Jin Cho S, La M, Ahn JK, Meadows GG, Joe CO (May 2001). "Tob-mediated cross-talk between MARCKS phosphorylation and ErbB-2 activation". Biochemical and Biophysical Research Communications. 283 (2): 273–7. doi:10.1006/bbrc.2001.4773. PMID   11327693.
12. Suzuki T, Matsuda S, Tsuzuku JK, Yoshida Y, Yamamoto T (Feb 2001). "A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob". Genes to Cells. 6 (2): 131–8. doi: 10.1046/j.1365-2443.2001.00406.x . PMID   11260258. S2CID   21599032.

Further reading

• Sasaki S, Imai K (Mar 2002). "[Monoclonal antibody induces apoptosis against cancer cells]". Nihon Rinsho. Japanese Journal of Clinical Medicine. 60 (3): 451–6. PMID   11904957.
• Yoshida Y, Matsuda S, Yamamoto T (May 1997). "Cloning and characterization of the mouse tob gene". Gene. 191 (1): 109–13. doi:10.1016/S0378-1119(97)00049-8. PMID   9210596.
• Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (Dec 1999). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene. 18 (52): 7432–41. doi:10.1038/sj.onc.1203193. PMID   10602502. S2CID   35769674.
• Yoshida Y, Tanaka S, Umemori H, Minowa O, Usui M, Ikematsu N, Hosoda E, Imamura T, Kuno J, Yamashita T, Miyazono K, Noda M, Noda T, Yamamoto T (Dec 2000). "Negative regulation of BMP/Smad signaling by Tob in osteoblasts". Cell. 103 (7): 1085–97. doi: 10.1016/S0092-8674(00)00211-7 . PMID   11163184. S2CID   18267832.
• Suzuki T, Matsuda S, Tsuzuku JK, Yoshida Y, Yamamoto T (Feb 2001). "A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob". Genes to Cells. 6 (2): 131–8. doi: 10.1046/j.1365-2443.2001.00406.x . PMID   11260258. S2CID   21599032.
• Jin Cho S, La M, Ahn JK, Meadows GG, Joe CO (May 2001). "Tob-mediated cross-talk between MARCKS phosphorylation and ErbB-2 activation". Biochemical and Biophysical Research Communications. 283 (2): 273–7. doi:10.1006/bbrc.2001.4773. PMID   11327693.
• Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (Jun 2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex". Japanese Journal of Cancer Research. 92 (6): 592–6. doi:10.1111/j.1349-7006.2001.tb01135.x. PMC   5926753 . PMID   11429045.
• Tzachanis D, Freeman GJ, Hirano N, van Puijenbroek AA, Delfs MW, Berezovskaya A, Nadler LM, Boussiotis VA (Dec 2001). "Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells". Nature Immunology. 2 (12): 1174–82. doi:10.1038/ni730. PMID   11694881. S2CID   38103879.
• Suzuki T, K-Tsuzuku J, Ajima R, Nakamura T, Yoshida Y, Yamamoto T (Jun 2002). "Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation". Genes & Development. 16 (11): 1356–70. doi:10.1101/gad.962802. PMC   186319 . PMID   12050114.
• Sasajima H, Nakagawa K, Yokosawa H (Jul 2002). "Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system". European Journal of Biochemistry. 269 (14): 3596–604. doi:10.1046/j.1432-1033.2002.03052.x. PMID   12135500.
• Maekawa M, Nishida E, Tanoue T (Oct 2002). "Identification of the Anti-proliferative protein Tob as a MAPK substrate". The Journal of Biological Chemistry. 277 (40): 37783–7. doi: 10.1074/jbc.M204506200 . PMID   12151396.
• Yoshida Y, von Bubnoff A, Ikematsu N, Blitz IL, Tsuzuku JK, Yoshida EH, Umemori H, Miyazono K, Yamamoto T, Cho KW (May 2003). "Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling". Mechanisms of Development. 120 (5): 629–37. doi:10.1016/S0925-4773(03)00020-0. PMID   12782279. S2CID   728736.
• Iwanaga K, Sueoka N, Sato A, Sakuragi T, Sakao Y, Tominaga M, Suzuki T, Yoshida Y, K-Tsuzuku J, Yamamoto T, Hayashi S, Nagasawa K, Sueoka E (Dec 2003). "Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer". Cancer Letters. 202 (1): 71–9. doi:10.1016/j.canlet.2003.08.019. PMID   14643028.
• Maekawa M, Yamamoto T, Nishida E (Apr 2004). "Regulation of subcellular localization of the antiproliferative protein Tob by its nuclear export signal and bipartite nuclear localization signal sequences". Experimental Cell Research. 295 (1): 59–65. doi:10.1016/j.yexcr.2003.12.016. PMID   15051490.
• Kawamura-Tsuzuku J, Suzuki T, Yoshida Y, Yamamoto T (Aug 2004). "Nuclear localization of Tob is important for regulation of its antiproliferative activity". Oncogene. 23 (39): 6630–8. doi:10.1038/sj.onc.1207890. PMID   15235587. S2CID   19519175.
• Okochi K, Suzuki T, Inoue J, Matsuda S, Yamamoto T (Feb 2005). "Interaction of anti-proliferative protein Tob with poly(A)-binding protein and inducible poly(A)-binding protein: implication of Tob in translational control". Genes to Cells. 10 (2): 151–63. doi: 10.1111/j.1365-2443.2005.00826.x . PMID   15676026. S2CID   40563615.

External links

• TOB1 human gene location in the UCSC Genome Browser .
• TOB1 human gene details in the UCSC Genome Browser .