TOB2

TOB2
Identifiers
Aliases	TOB2 , TOB4, TOBL, TROB2, transducer of ERBB2, 2, APRO5
External IDs	OMIM: 607396 MGI: 1888525 HomoloGene: 9447 GeneCards: TOB2
Gene location (Human)
Chr.	Chromosome 22 (human)
End	41,446,801 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	81,742,997 bp
RNA expression pattern
	Top expressed in
	optic nerve; ; gastric mucosa; ; popliteal artery; ; gastrocnemius muscle; ; vastus lateralis muscle; ; body of tongue; ; left uterine tube; ; left lobe of thyroid gland; ; coronary artery; ; nipple;
	Top expressed in
	ascending aorta; ; aortic valve; ; retinal pigment epithelium; ; ciliary body; ; brown adipose tissue; ; masseter muscle; ; myocardium of ventricle; ; iris; ; left lung lobe; ; trachea;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; vitamin D receptor binding ; transcription corepressor activity ;
Cellular component	nucleus ; cytoplasm ; cytosol ;
Biological process	positive regulation of ossification ; female gamete generation ; negative regulation of osteoclast differentiation ; regulation of gene expression ; negative regulation of cell population proliferation ; signaling ; negative regulation of nucleic acid-templated transcription ;
	Sources:Amigo / QuickGO
Orthologs
	10766
	57259
	ENSG00000183864
	ENSMUSG00000048546
	Q14106
	Q9JM55
	NM_016272
	NM_020507
	NP_057356
	NP_065253
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 25, 2023

Protein Tob2 (transducer of ERBB2, 2) is a protein that in humans is encoded by the TOB2 gene.^[5]^[6]^[7]^[8]

Interactions

TOB2 has been shown to interact with CNOT7.^[5]

Related Research Articles

Protein Tob1 is a protein that in humans is encoded by the TOB1 gene.

CCR4-NOT transcription complex subunit 7 is a protein that in humans is encoded by the CNOT7 gene. It is a subunit of the CCR4-Not deadenylase complex.

Protein BTG1 is a protein that in humans is encoded by the BTG1 gene.

Hermansky–Pudlak syndrome 4 protein is a protein that in humans is encoded by the HPS4 gene.

Hypermethylated in cancer 2 protein is a protein that in humans is encoded by the HIC2 gene.

Cold shock domain-containing protein C2 is a protein that in humans is encoded by the CSDC2 gene.

ADP-ribosylation factor GTPase-activating protein 3 is a protein that in humans is encoded by the ARFGAP3 gene.

Polymerase delta-interacting protein 3 is an enzyme that in humans is encoded by the POLDIP3 gene.

GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP1 gene.

Protein BTG3 is a protein that in humans is encoded by the BTG3 gene.

KIAA0930 is a protein that, in humans, is encoded by the KIAA0930 gene.

Probable tubulin polyglutamylase TTLL1 is an enzyme that in humans is encoded by the TTLL1 gene.

CCR4-NOT transcription complex subunit 2 is a protein that in humans is encoded by the CNOT2 gene. It is a subunit of the CCR4-Not deadenylase complex.

ADM2 is a protein that in humans is encoded by the ADM2 gene.

Apolipoprotein L6 is a protein that in humans is encoded by the APOL6 gene.

P2X purinoceptor 6 is a protein that in humans is encoded by the P2RX6 gene.

Cat eye syndrome critical region protein 1 is a protein that in humans is encoded by the CECR1 gene.

CCR4-NOT transcription complex subunit 6 is a protein that in humans is encoded by the CNOT6 gene.

Dual specificity protein phosphatase 18 is an enzyme that is encoded by the DUSP18 gene in humans.

Protein BTG4 also known as BTG family member 4 is a protein that in humans is encoded by the BTG4 gene (B-cell translocation gene 4). BTG4 has anti-proliferative properties and can induce G₁ cell cycle arrest.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000183864 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048546 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (Jan 2000). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene. 18 (52): 7432–41. doi: 10.1038/sj.onc.1203193 . PMID 10602502.
↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.
1 2 "Entrez Gene: TOB2 transducer of ERBB2, 2".
↑ "TOB2 transducer of ERBB2, 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2023-09-24.

Hirosawa M, Nagase T, Murahashi Y, et al. (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. doi: 10.1093/dnares/8.1.1 . PMID 11258795.
Suzuki T, Matsuda S, Tsuzuku JK, et al. (2001). "A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob". Genes Cells. 6 (2): 131–8. doi: 10.1046/j.1365-2443.2001.00406.x . PMID 11260258.
Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex". Jpn. J. Cancer Res. 92 (6): 592–6. doi:10.1111/j.1349-7006.2001.tb01135.x. PMC 5926753 . PMID 11429045.
Sasajima H, Nakagawa K, Yokosawa H (2002). "Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system". Eur. J. Biochem. 269 (14): 3596–604. doi:10.1046/j.1432-1033.2002.03052.x. PMID 12135500.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604 . PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000183864 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048546 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10602502-5] 1 2 Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (Jan 2000). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene. 18 (52): 7432–41. doi: 10.1038/sj.onc.1203193 . PMID 10602502.

[pmid10591208-6] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.

[entrez-7] 1 2 "Entrez Gene: TOB2 transducer of ERBB2, 2".

[8] "TOB2 transducer of ERBB2, 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2023-09-24.

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TOB2

Contents

Interactions

Related Research Articles

References

Further reading