TOMM34

TOMM34
Identifiers
Aliases	TOMM34 , HTOM34P, TOM34, URCC3, translocase of outer mitochondrial membrane 34
External IDs	OMIM: 616049 MGI: 1914395 HomoloGene: 4956 GeneCards: TOMM34
Gene location (Human)
Chr.	Chromosome 20 (human)
End	44,960,397 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	163,913,089 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; nucleus accumbens; ; right uterine tube; ; caudate nucleus; ; Left adrenal gland; ; putamen; ; cingulate gyrus; ; prefrontal cortex; ; Brodmann area 9; ; anterior pituitary;
	Top expressed in
	blood; ; cumulus cell; ; subiculum; ; pontine nuclei; ; superior frontal gyrus; ; pituitary gland; ; Ankle joint; ; pineal gland; ; utricle; ; endocardial cushion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; heat shock protein binding ;
Cellular component	integral component of membrane ; mitochondrial outer membrane ; membrane ; mitochondrion ; nucleus ; nucleoplasm ; cytoplasm ; cytosol ;
Biological process	protein targeting to mitochondrion ;
	Sources:Amigo / QuickGO
Orthologs
	10953
	67145
	ENSG00000025772
	ENSMUSG00000018322
	Q15785
	Q9CYG7
	NM_006809
	NM_001291155 ; NM_025996
	NP_006800
	NP_001278084 ; NP_080272
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

Mitochondrial import receptor subunit TOM34 is a protein that in humans is encoded by the TOMM34 gene.^[5]^[6]

The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats.^[6]

Related Research Articles

Mitochondrial import inner membrane translocase subunit Tim8 A, also known as Deafness-dystonia peptide or protein is an enzyme that in humans is encoded by the TIMM8A gene. This translocase has similarity to yeast mitochondrial proteins that are involved in the import of metabolite transporters from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Deafness-dystonia syndrome and it is postulated that MTS/DFN-1 is a mitochondrial disease caused by a defective mitochondrial protein import system.

Mitochondrial import receptor subunit TOM20 homolog is a protein that in humans is encoded by the TOMM20 gene. TOM20 is one of the receptor systems of the TOM complex in the outer mitochondrial membrane (OMM).

V-type proton ATPase subunit D is an enzyme that in humans is encoded by the ATP6V1D gene.

Mitochondrial import receptor subunit TOM22 homolog is a protein that in humans is encoded by the TOMM22 gene.

ATP synthase subunit b, mitochondrial is an enzyme that in humans is encoded by the ATP5PB gene.

The translocase of the outer membrane (TOM) is a complex of proteins found in the outer mitochondrial membrane of the mitochondria. It allows movement of proteins through this barrier and into the intermembrane space of the mitochondrion. Most of the proteins needed for mitochondrial function are encoded by the nucleus of the cell. The outer membrane of the mitochondrion is impermeable to large molecules greater than 5000 Daltons. The TOM works in conjunction with the translocase of the inner membrane (TIM) to translocate proteins into the mitochondrion. Many of the proteins in the TOM complex, such as TOMM22, were first identified in Neurospora crassa and Saccharomyces cerevisiae. Many of the genes encoding these proteins are designated as TOMM complex genes.

Mitochondrial import inner membrane translocase subunit Tim10 is an enzyme that in humans is encoded by the TIMM10 gene.

Metaxin 1, also known as MTX1, is a protein which in humans is encoded by the MTX1 gene.

Mitochondrial import receptor subunit TOM40B is a protein that in humans is encoded by the TOMM40L gene.

Mitochondrial import inner membrane translocase subunit TIM44 is an enzyme that in humans is encoded by the TIMM44 gene.

Mitochondrial import inner membrane translocase subunit Tim9 B is an enzyme that in humans is encoded by the FXC1 gene.

Mitochondrial import receptor subunit TOM70 is a protein that in humans is encoded by the TOMM70A gene.

Mitochondrial import inner membrane translocase subunit Tim23 is an enzyme that in humans is encoded by the TIMM23 gene.

Mitochondrial import inner membrane translocase subunit Tim17-A is an enzyme that in humans is encoded by the TIMM17A gene.

Translocase of outer mitochondrial membrane 40 homolog (yeast), also known as TOMM40, is a protein which in humans is encoded by the TOMM40 gene.

Mitochondrial import inner membrane translocase subunit Tim9 is an enzyme that in humans is encoded by the TIMM9 gene.

Mitochondrial import inner membrane translocase subunit Tim22 is an enzyme that in humans is encoded by the TIMM22 gene.

ADP/ATP translocase 3, also known as solute carrier family 25 member 6, is a protein that in humans is encoded by the SLC25A6 gene.

Mitochondrial processing peptidase is an enzyme complex found in mitochondria which cleaves signal sequences from mitochondrial proteins. In humans this complex is composed of two subunits encoded by the genes PMPCA, and PMPCB. The enzyme is also known as. This enzyme catalyses the following chemical reaction

ADP/ATP translocase 2 is a protein that in humans is encoded by the SLC25A5 gene on the X chromosome.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000025772 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018322 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nuttall SD, Hanson BJ, Mori M, Hoogenraad NJ (Oct 1997). "hTom34: a novel translocase for the import of proteins into human mitochondria". DNA Cell Biol. 16 (9): 1067–74. doi:10.1089/dna.1997.16.1067. PMID 9324309.
1 2 "Entrez Gene: TOMM34 translocase of outer mitochondrial membrane 34".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Young JC, Obermann WM, Hartl FU (1998). "Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90". J. Biol. Chem. 273 (29): 18007–10. doi: 10.1074/jbc.273.29.18007 . PMID 9660753.
Chewawiwat N, Yano M, Terada K, et al. (1999). "Characterization of the novel mitochondrial protein import component, Tom34, in mammalian cells". J. Biochem. 125 (4): 721–7. doi:10.1093/oxfordjournals.jbchem.a022342. PMID 10101285.
Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID 11780052.
Mukhopadhyay A, Avramova LV, Weiner H (2002). "Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins". Arch. Biochem. Biophys. 400 (1): 97–104. doi:10.1006/abbi.2002.2777. PMID 11913975.
Yang CS, Weiner H (2002). "Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol". Arch. Biochem. Biophys. 400 (1): 105–10. doi:10.1006/abbi.2002.2778. PMID 11913976.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Shimokawa T, Matsushima S, Tsunoda T, et al. (2006). "Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target". Int. J. Oncol. 29 (2): 381–6. doi: 10.3892/ijo.29.2.381 . PMID 16820880.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000025772 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018322 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9324309-5] Nuttall SD, Hanson BJ, Mori M, Hoogenraad NJ (Oct 1997). "hTom34: a novel translocase for the import of proteins into human mitochondria". DNA Cell Biol. 16 (9): 1067–74. doi:10.1089/dna.1997.16.1067. PMID 9324309.

[entrez-6] 1 2 "Entrez Gene: TOMM34 translocase of outer mitochondrial membrane 34".

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TOMM34

Related Research Articles

References

Further reading