TP53RK

TP53RK
Identifiers
Aliases	TP53RK , BUD32, C20orf64, Nori-2, Nori-2p, PRPK, dJ101A2, TP53 regulating kinase, GAMOS4, TPRKB
External IDs	OMIM: 608679; MGI: 1914050; HomoloGene: 6042; GeneCards: TP53RK; OMA:TP53RK - orthologs
EC number	3.6.-.-
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.12 Start 46,684,365 bp [1] End 46,689,444 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H3 Start 166,634,451 bp [2] End 166,641,425 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence islet of Langerhans bronchial epithelial cell stromal cell of endometrium gonad cartilage tissue olfactory zone of nasal mucosa right adrenal cortex epithelium of nasopharynx Top expressed in spermatid female urethra embryo granulocyte embryo lumbar spinal ganglion primitive streak stroma of kidney epiblast yolk sac More reference expression data BioGPS n/a
Gene ontology Molecular function kinase activity transferase activity nucleotide binding protein kinase activity p53 binding protein binding ATP binding hydrolase activity phosphotransferase activity, alcohol group as acceptor protein serine/threonine kinase activity Cellular component cytosol membrane nucleus nucleoplasm EKC/KEOPS complex cytoplasm Biological process protein phosphorylation phosphorylation tRNA threonylcarbamoyladenosine metabolic process tRNA processing regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 112858 76367 Ensembl ENSG00000172315 ENSMUSG00000042854 UniProt Q96S44 Q99PW4 RefSeq (mRNA) NM_033550 NM_023815 RefSeq (protein) NP_291028 NP_076304.2 Location (UCSC) Chr 20: 46.68 – 46.69 Mb Chr 2: 166.63 – 166.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

TP53-regulating kinase, also known as PRPK is an enzyme that in humans is encoded by the TP53RK gene. ^{[5] [6] [7]} This protein is a serine/threonine protein kinase that phosphorylates p53 at Ser15.

PRPK is part of the KEOPS/EKC complex, which participates in transcription control, ^[8] telomere regulation ^[9] and tRNA modification. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000172315 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042854 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Abe Y, Matsumoto S, Wei S, Nezu K, Miyoshi A, Kito K, Ueda N, Shigemoto K, Hitsumoto Y, Nikawa J, Enomoto Y (Nov 2001). "Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes". The Journal of Biological Chemistry. 276 (47): 44003–11. doi: 10.1074/jbc.M105669200 . PMID   11546806.
6. Facchin S, Lopreiato R, Ruzzene M, Marin O, Sartori G, Götz C, Montenarh M, Carignani G, Pinna LA (Aug 2003). "Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency". FEBS Letters. 549 (1–3): 63–6. doi:10.1016/S0014-5793(03)00770-1. PMID   12914926. S2CID   24581860.
7. "Entrez Gene: TP53RK TP53 regulating kinase".
8. Kisseleva-Romanova E, Lopreiato R, Baudin-Baillieu A, Rousselle JC, Ilan L, Hofmann K, Namane A, Mann C, Libri D (Aug 2006). "Yeast homolog of a cancer-testis antigen defines a new transcription complex". The EMBO Journal. 25 (15): 3576–85. doi:10.1038/sj.emboj.7601235. PMC   1538566 . PMID   16874308.
9. Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D (Mar 2006). "A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator". Cell. 124 (6): 1155–68. doi: 10.1016/j.cell.2005.12.044 . PMID   16564010. S2CID   13928061.
10. Srinivasan M, Mehta P, Yu Y, Prugar E, Koonin EV, Karzai AW, Sternglanz R (Mar 2011). "The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A". The EMBO Journal. 30 (5): 873–81. doi:10.1038/emboj.2010.343. PMC   3049205 . PMID   21183954.

Further reading

• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Miyoshi A, Kito K, Aramoto T, Abe Y, Kobayashi N, Ueda N (Apr 2003). "Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein". Biochemical and Biophysical Research Communications. 303 (2): 399–405. doi:10.1016/S0006-291X(03)00333-4. PMID   12659830.
• Wang SC, Lien HC, Xia W, Chen IF, Lo HW, Wang Z, Ali-Seyed M, Lee DF, Bartholomeusz G, Ou-Yang F, Giri DK, Hung MC (Sep 2004). "Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2". Cancer Cell. 6 (3): 251–61. doi: 10.1016/j.ccr.2004.07.012 . PMID   15380516.
• Abe Y, Takeuchi T, Imai Y, Murase R, Kamei Y, Fujibuchi T, Matsumoto S, Ueda N, Ogasawara M, Shigemoto K, Kito K (May 2006). "A Small Ras-like protein Ray/Rab1c modulates the p53-regulating activity of PRPK". Biochemical and Biophysical Research Communications. 344 (1): 377–85. doi:10.1016/j.bbrc.2006.03.071. PMID   16600182.