TPPP

TPPP
Identifiers
Aliases	TPPP , TPPP/p25, TPPP1, p24, p25, p25alpha, tubulin polymerization promoting protein
External IDs	OMIM: 608773; MGI: 1920198; HomoloGene: 21389; GeneCards: TPPP; OMA:TPPP - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5p15.33 Start 659,862 bp [1] End 693,352 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 C1 Start 74,157,526 bp [2] End 74,183,872 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 middle temporal gyrus postcentral gyrus internal globus pallidus entorhinal cortex inferior ganglion of vagus nerve superior frontal gyrus ventral tegmental area superior vestibular nucleus subthalamic nucleus Top expressed in primary motor cortex ventral tegmental area cingulate gyrus piriform cortex dentate gyrus dentate gyrus of hippocampal formation granule cell superior colliculus lateral hypothalamus subiculum suprachiasmatic nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule binding protein binding tubulin binding Cellular component cytoplasm perinuclear region of cytoplasm myelin sheath microtubule cytoskeleton nucleus mitochondrion cytosol microtubule bundle Biological process microtubule polymerization positive regulation of protein-containing complex assembly positive regulation of protein polymerization microtubule bundle formation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11076 72948 Ensembl ENSG00000171368 ENSMUSG00000021573 UniProt O94811 Q7TQD2 RefSeq (mRNA) NM_007030 NM_182839 RefSeq (protein) NP_008961 NP_878259 Location (UCSC) Chr 5: 0.66 – 0.69 Mb Chr 13: 74.16 – 74.18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tubulin polymerization-promoting protein is a protein that in humans is encoded by the TPPP gene. ^{[5] [6] [7] [8] [9]}

This protein has been linked to multiple sclerosis myelin lesions and CSF abnormalities in multiple sclerosis patients. ^[10]

This has also been linked to Parkinson's and Alzheimer's Disease ^{[11] [12]}

References

1. GRCh38: Ensembl release 89: ENSG00000171368 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021573 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Muramatsu M, Hori T, Saito T (Apr 1999). "A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3". J Hum Genet. 44 (2): 121–2. doi: 10.1007/s100380050122 . PMID   10083737.
6. Hlavanda E, Kovacs J, Olah J, Orosz F, Medzihradszky KF, Ovadi J (Jul 2002). "Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations". Biochemistry. 41 (27): 8657–64. doi:10.1021/bi020140g. PMID   12093283.
7. Lindersson E, Lundvig D, Petersen C, Madsen P, Nyengaard JR, Hojrup P, Moos T, Otzen D, Gai WP, Blumbergs PC, Jensen PH (Feb 2005). "p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies". J Biol Chem. 280 (7): 5703–15. doi: 10.1074/jbc.M410409200 . PMID   15590652.
8. Vincze O, Tokesi N, Olah J, Hlavanda E, Zotter A, Horvath I, Lehotzky A, Tirian L, Medzihradszky KF, Kovacs J, Orosz F, Ovadi J (Nov 2006). "Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions". Biochemistry. 45 (46): 13818–26. doi:10.1021/bi061305e. PMID   17105200.
9. "Entrez Gene: TPPP brain-specific protein p25 alpha".
10. Vincze O, Oláh J, Zádori D, Klivényi P, Vécsei L, Ovádi J (May 2011). "A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis". Biochem. Biophys. Res. Commun. 409 (1): 137–41. doi:10.1016/j.bbrc.2011.04.130. PMID   21565174.
11. Kovács, Gábor G.; László, Lajos; Kovács, János; Jensen, Poul Henning; Lindersson, Evo; Botond, Gergő; Molnár, Tamás; Perczel, András; Hudecz, Ferenc (2004-11-01). "Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies". Neurobiology of Disease. 17 (2): 155–162. doi:10.1016/j.nbd.2004.06.006. PMID   15474353. S2CID   42518910.
12. Kovács, Gábor G.; Gelpi, Ellen; Lehotzky, Attila; Höftberger, Romana; Erdei, Anna; Budka, Herbert; Ovádi, Judit (2006-11-23). "The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases". Acta Neuropathologica. 113 (2): 153–161. doi:10.1007/s00401-006-0167-4. ISSN   0001-6322. PMID   17123092. S2CID   28792202.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Martín CP, Vázquez J, Avila J, Moreno FJ (2002). "P24, a glycogen synthase kinase 3 (GSK 3) inhibitor". Biochim. Biophys. Acta. 1586 (1): 113–22. doi: 10.1016/s0925-4439(01)00092-8 . hdl: 10261/252211 . PMID   11781156.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Tirián L, Hlavanda E, Oláh J, et al. (2004). "TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation". Proc. Natl. Acad. Sci. U.S.A. 100 (24): 13976–81. doi: 10.1073/pnas.2436331100 . PMC   283531 . PMID   14623963.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Lehotzky A, Tirián L, Tökési N, et al. (2005). "Dynamic targeting of microtubules by TPPP/p25 affects cell survival". J. Cell Sci. 117 (Pt 25): 6249–59. doi: 10.1242/jcs.01550 . hdl: 21.11116/0000-0002-1119-F . PMID   15564385.
• DeGiorgis JA, Jaffe H, Moreira JE, et al. (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". J. Proteome Res. 4 (2): 306–15. doi:10.1021/pr0498436. PMID   15822905.
• Jämsä A, Bäckström A, Gustafsson E, et al. (2006). "Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells". Biochem. Biophys. Res. Commun. 345 (1): 324–31. doi:10.1016/j.bbrc.2006.04.032. PMID   16678793.
• Skjoerringe T, Lundvig DM, Jensen PH, Moos T (2006). "P25alpha/Tubulin polymerization promoting protein expression by myelinating oligodendrocytes of the developing rat brain". J. Neurochem. 99 (1): 333–42. doi: 10.1111/j.1471-4159.2006.04073.x . PMID   16879710. S2CID   86488870.
• Oláh J, Tokési N, Vincze O, et al. (2006). "Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies". FEBS Lett. 580 (25): 5807–14. doi: 10.1016/j.febslet.2006.09.037 . PMID   17027006. S2CID   1513728.
• Hlavanda E, Klement E, Kókai E, et al. (2007). "Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted by different kinases". J. Biol. Chem. 282 (40): 29531–9. doi: 10.1074/jbc.M703466200 . hdl: 2437/3435 . PMID   17693641.
• Song YJ, Lundvig DM, Huang Y, et al. (2007). "p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy". Am. J. Pathol. 171 (4): 1291–303. doi:10.2353/ajpath.2007.070201. PMC   1988878 . PMID   17823288.