TRAT1

TRAT1
Identifiers
Aliases	TRAT1 , TCRIM, TRIM, HSPC062, pp29/30, T cell receptor associated transmembrane adaptor 1, T-cell receptor associated transmembrane adaptor 1
External IDs	OMIM: 604962; MGI: 1924897; HomoloGene: 41130; GeneCards: TRAT1; OMA:TRAT1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q13.13 Start 108,822,770 bp [1] End 108,855,005 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 B5 Start 48,551,137 bp [2] End 48,592,384 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus buccal mucosa cell lymph node testicle blood granulocyte appendix epithelium of nasopharynx spleen epithelium of colon Top expressed in thymus blood mesenteric lymph nodes embryo spleen subcutaneous adipose tissue superior frontal gyrus gastrula primary visual cortex vastus lateralis muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane receptor protein tyrosine kinase adaptor activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane T cell receptor complex Biological process positive regulation of calcium-mediated signaling adaptive immune response immune system process positive regulation of T cell receptor signaling pathway negative regulation of transport cellular defense response T cell receptor signaling pathway negative regulation of receptor recycling signal transduction phosphatidylinositol phosphate biosynthetic process transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50852 77647 Ensembl ENSG00000163519 ENSMUSG00000030775 UniProt Q6PIZ9 Q3UU67 RefSeq (mRNA) NM_016388 NM_001317747 NM_198297 RefSeq (protein) NP_001304676 NP_057472 NP_938039 Location (UCSC) Chr 3: 108.82 – 108.86 Mb Chr 16: 48.55 – 48.59 Mb PubMed search [3] [4]
Wikidata
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T-cell receptor-associated transmembrane adapter 1 is a protein that in humans is encoded by the TRAT1 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000163519 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030775 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hubener C, Mincheva A, Lichter P, Schraven B, Bruyns E (Mar 2000). "Genomic organization and chromosomal localization of the human gene encoding the T-cell receptor-interacting molecule (TRIM)". Immunogenetics. 51 (2): 154–8. doi:10.1007/s002510050024. PMID   10663578. S2CID   43325566.
6. Bruyns E, Marie-Cardine A, Kirchgessner H, Sagolla K, Shevchenko A, Mann M, Autschbach F, Bensussan A, Meuer S, Schraven B (Sep 1998). "T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane". J Exp Med. 188 (3): 561–75. doi:10.1084/jem.188.3.561. PMC   2212462 . PMID   9687533.
7. "Entrez Gene: TRAT1 T cell receptor associated transmembrane adaptor 1".

Further reading

• Zhang W, Samelson LE (2000). "The role of membrane-associated adaptors in T cell receptor signalling". Semin. Immunol. 12 (1): 35–41. doi:10.1006/smim.2000.0205. PMID   10723796.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Kirchgessner H, Dietrich J, Scherer J, et al. (2001). "The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain". J. Exp. Med. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMC   2193385 . PMID   11390434.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Tedoldi S, Paterson JC, Hansmann ML, et al. (2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers". Blood. 107 (1): 213–21. doi: 10.1182/blood-2005-06-2273 . PMID   16160011. S2CID   340034.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.