TRMT12

TRMT12
Identifiers
Aliases	TRMT12 , TRM12, TYW2, tRNA methyltransferase 12 homolog
External IDs	OMIM: 611244; MGI: 1915510; HomoloGene: 32379; GeneCards: TRMT12; OMA:TRMT12 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q24.13 Start 124,450,820 bp [1] End 124,462,150 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 D1 Start 58,744,523 bp [2] End 58,748,976 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm endothelial cell Epithelium of choroid plexus monocyte islet of Langerhans Achilles tendon testicle gastrocnemius muscle secondary oocyte amniotic fluid Top expressed in superior cervical ganglion zygote granulocyte right kidney tail of embryo embryo ventricular zone proximal tubule dentate gyrus of hippocampal formation granule cell muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transferase activity tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity tRNA methyltransferase activity Cellular component cytoplasm Biological process tRNA processing tRNA methylation wybutosine biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55039 68260 Ensembl ENSG00000183665 ENSMUSG00000037085 UniProt Q53H54 Q8BG71 RefSeq (mRNA) NM_017956 NM_026642 RefSeq (protein) NP_060426 NP_080918 Location (UCSC) Chr 8: 124.45 – 124.46 Mb Chr 15: 58.74 – 58.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

tRNA wybutosine-synthesizing protein 2 homolog is a protein that in humans is encoded by the TRMT12 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000183665 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037085 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kalhor HR, Penjwini M, Clarke S (Jul 2005). "A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA". Biochem Biophys Res Commun. 334 (2): 433–40. doi:10.1016/j.bbrc.2005.06.111. PMID   16005430.
6. Noma A, Suzuki T (Dec 2006). "Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis". Nucleic Acids Symp Ser (Oxf). 50 (50): 65–6. doi:10.1093/nass/nrl032. PMID   17150819.
7. "Entrez Gene: TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rodriguez V, Chen Y, Elkahloun A, et al. (2007). "Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer". Genes Chromosomes Cancer. 46 (7): 694–707. doi:10.1002/gcc.20454. PMID   17440925. S2CID   36237771.