TRMT12

TRMT12
Identifiers
Aliases	TRMT12 , TRM12, TYW2, tRNA methyltransferase 12 homolog
External IDs	OMIM: 611244 MGI: 1915510 HomoloGene: 32379 GeneCards: TRMT12
Gene location (Human)
Chr.	Chromosome 8 (human)
End	124,462,150 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	58,748,976 bp
RNA expression pattern
	Top expressed in
	sperm; ; endothelial cell; ; monocyte; ; islet of Langerhans; ; Achilles tendon; ; gastrocnemius muscle; ; secondary oocyte; ; amniotic fluid; ; stromal cell of endometrium; ; parotid gland;
	Top expressed in
	superior cervical ganglion; ; proximal tubule; ; interventricular septum; ; morula; ; yolk sac; ; visual cortex; ; neural tube; ; esophagus; ; secondary oocyte; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; transferase activity ; tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity ; tRNA methyltransferase activity ;
Cellular component	cytoplasm ;
Biological process	tRNA processing ; tRNA methylation ; wybutosine biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	55039
	68260
	ENSG00000183665
	ENSMUSG00000037085
	Q53H54
	Q8BG71
	NM_017956
	NM_026642
	NP_060426
	NP_080918
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

tRNA wybutosine-synthesizing protein 2 homolog is a protein that in humans is encoded by the TRMT12 gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000183665 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037085 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kalhor HR, Penjwini M, Clarke S (Jul 2005). "A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA". Biochem Biophys Res Commun. 334 (2): 433–40. doi:10.1016/j.bbrc.2005.06.111. PMID 16005430.
↑ Noma A, Suzuki T (Dec 2006). "Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis". Nucleic Acids Symp Ser (Oxf). 50 (50): 65–6. doi:10.1093/nass/nrl032. PMID 17150819.
↑ "Entrez Gene: TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316 . PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rodriguez V, Chen Y, Elkahloun A, et al. (2007). "Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer". Genes Chromosomes Cancer. 46 (7): 694–707. doi:10.1002/gcc.20454. PMID 17440925. S2CID 36237771.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000183665 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037085 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16005430-5] Kalhor HR, Penjwini M, Clarke S (Jul 2005). "A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA". Biochem Biophys Res Commun. 334 (2): 433–40. doi:10.1016/j.bbrc.2005.06.111. PMID 16005430.

[pmid17150819-6] Noma A, Suzuki T (Dec 2006). "Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis". Nucleic Acids Symp Ser (Oxf). 50 (50): 65–6. doi:10.1093/nass/nrl032. PMID 17150819.

[entrez-7] "Entrez Gene: TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)".

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TRMT12

Related Research Articles

References

Further reading