TSC22D1

TSC22D1
Identifiers
Aliases	TSC22D1 , Ptg-2, TGFB1I4, TSC22, TSC22 domain family member 1
External IDs	OMIM: 607715; MGI: 109127; HomoloGene: 7573; GeneCards: TSC22D1; OMA:TSC22D1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q14.11 Start 44,432,143 bp [1] End 44,577,147 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14 D3|14 40.44 cM Start 76,652,401 bp [2] End 76,745,205 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus tibia dorsal motor nucleus of vagus nerve postcentral gyrus beta cell entorhinal cortex mucosa of paranasal sinus caput epididymis Top expressed in iris medullary collecting duct renal corpuscle vestibular sensory epithelium epithelium of lens Epithelium of choroid plexus ciliary body condyle fossa vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus Biological process regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8848 21807 Ensembl ENSG00000102804 ENSMUSG00000022010 UniProt Q15714 P62500 RefSeq (mRNA) NM_001243797 NM_001243798 NM_001243799 NM_006022 NM_183422 NM_001177751 NM_009366 NM_207652 NM_001310646 NM_001310647 RefSeq (protein) NP_001230726 NP_001230727 NP_001230728 NP_006013 NP_904358 NP_001171222 NP_001297575 NP_001297576 NP_033392 NP_997535 Location (UCSC) Chr 13: 44.43 – 44.58 Mb Chr 14: 76.65 – 76.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

TSC22 domain family protein 1 is a protein that in humans is encoded by the TSC22D1 gene. ^{[5] [6]}

TSC22 encodes a transcription factor and belongs to the large family of early response genes. ^[7]

TSC22D1 forms homodimers via its conserved leucine zipper domain and heterodimerizes with TSC22D4. TSC22D1 has transcriptional repressor activity. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000102804 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022010 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jay P, Ji JW, Marsollier C, Taviaux S, Berge-Lefranc JL, Berta P (Jul 1996). "Cloning of the human homologue of the TGF beta-stimulated clone 22 gene". Biochem Biophys Res Commun. 222 (3): 821–6. doi:10.1006/bbrc.1996.0825. PMID   8651929.
6. Ohta S, Shimekake Y, Nagata K (Mar 1997). "Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter". Eur J Biochem. 242 (3): 460–6. doi: 10.1111/j.1432-1033.1996.460rr.x . PMID   9022669.
7. "Entrez Gene: TSC22D1 TSC22 domain family, member 1".
8. Kester HA, Blanchetot C, den Hertog J, van der Saag PT, van der Burg B (September 1999). "Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity". J. Biol. Chem. 274 (39): 27439–47. doi: 10.1074/jbc.274.39.27439 . PMID   10488076.

Further reading

• Shibanuma M, Kuroki T, Nose K (1992). "Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor beta 1 and other growth factors". J. Biol. Chem. 267 (15): 10219–24. doi: 10.1016/S0021-9258(19)50006-0 . PMID   1587811.
• Dmitrenko VV, Garifulin OM, Shostak EA, et al. (1997). "[The characteristics of different types of mRNA expressed in the human brain]". Tsitol. Genet. 30 (5): 41–7. PMID   9026990.
• Kester HA, Blanchetot C, den Hertog J, et al. (1999). "Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity". J. Biol. Chem. 274 (39): 27439–47. doi: 10.1074/jbc.274.39.27439 . PMID   10488076.
• Hino S, Kawamata H, Uchida D, et al. (2001). "Nuclear translocation of TSC-22 (TGF-beta-stimulated clone-22) concomitant with apoptosis: TSC-22 as a putative transcriptional regulator". Biochem. Biophys. Res. Commun. 278 (3): 659–64. doi:10.1006/bbrc.2000.3840. PMID   11095965.
• Hino S, Kawamata H, Omotehara F, et al. (2002). "Leucine zipper structure of TSC-22 (TGF-beta stimulated clone-22) markedly inhibits the anchorage-independent growth of salivary gland cancer cells". Oncol. Rep. 9 (2): 371–4. doi:10.3892/or.9.2.371. PMID   11836610.
• Hino S, Kawamata H, Omotehara F, et al. (2002). "Cytoplasmic TSC-22 (transforming growth factor-beta-stimulated clone-22) markedly enhances the radiation sensitivity of salivary gland cancer cells". Biochem. Biophys. Res. Commun. 292 (4): 957–63. doi:10.1006/bbrc.2002.6776. PMID   11944908.
• Ohara O, Nagase T, Mitsui G, et al. (2003). "Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method". DNA Res. 9 (2): 47–57. doi: 10.1093/dnares/9.2.47 . PMID   12056414.
• Gupta RA, Sarraf P, Brockman JA, et al. (2003). "Peroxisome proliferator-activated receptor gamma and transforming growth factor-beta pathways inhibit intestinal epithelial cell growth by regulating levels of TSC-22". J. Biol. Chem. 278 (9): 7431–8. doi: 10.1074/jbc.M208076200 . PMID   12468551.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Sugawara F, Yamada Y, Watanabe R, et al. (2004). "The role of the TSC-22 (-396) A/G variant in the development of diabetic nephropathy". Diabetes Res. Clin. Pract. 60 (3): 191–7. doi:10.1016/S0168-8227(03)00038-X. PMID   12757981.
• Uchida D, Omotehara F, Nakashiro K, et al. (2003). "Posttranscriptional regulation of TSC-22 (TGF-beta-stimulated clone-22) gene by TGF-beta 1". Biochem. Biophys. Res. Commun. 305 (4): 846–54. doi:10.1016/S0006-291X(03)00854-4. PMID   12767908.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Choi SJ, Moon JH, Ahn YW, et al. (2005). "Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation". Mol. Cell. Biochem. 271 (1–2): 23–8. doi:10.1007/s11010-005-3456-7. PMID   15881652. S2CID   23414101.
• Rentsch CA, Cecchini MG, Schwaninger R, et al. (2006). "Differential expression of TGFbeta-stimulated clone 22 in normal prostate and prostate cancer". Int. J. Cancer. 118 (4): 899–906. doi: 10.1002/ijc.21449 . PMID   16106424. S2CID   44422160.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi: 10.1016/j.cell.2005.08.029 . hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Lu Y, Kitaura J, Oki T, et al. (2007). "Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD". Leukemia. 21 (11): 2246–57. doi:10.1038/sj.leu.2404883. PMID   17690703. S2CID   2787939.

External links

• TSC22D1 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.