TSEN2

TSEN2
Identifiers
Aliases	TSEN2 , PCH2B, SEN2, SEN2L, tRNA splicing endonuclease subunit 2
External IDs	OMIM: 608753 MGI: 2141599 HomoloGene: 41622 GeneCards: TSEN2
Gene location (Human)
Chr.	Chromosome 3 (human)
End	12,541,549 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	115,555,589 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; body of pancreas; ; cerebellar hemisphere; ; right uterine tube; ; tibial nerve; ; left uterine tube; ; body of stomach; ; anterior pituitary; ; ganglionic eminence; ; sural nerve;
	Top expressed in
	yolk sac; ; primitive streak; ; interventricular septum; ; hand; ; superior cervical ganglion; ; otolith organ; ; utricle; ; endocardial cushion; ; facial motor nucleus; ; medial ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	tRNA-intron endonuclease activity ; protein binding ; lyase activity ; nucleic acid binding ; nuclease activity ;
Cellular component	centrosome ; nucleolus ; nucleus ; tRNA-intron endonuclease complex ; nucleoplasm ; cytosol ;
Biological process	mRNA processing ; tRNA-type intron splice site recognition and cleavage ; RNA phosphodiester bond hydrolysis, endonucleolytic ; tRNA splicing, via endonucleolytic cleavage and ligation ; RNA phosphodiester bond hydrolysis ; tRNA processing ; nucleic acid phosphodiester bond hydrolysis ;
	Sources:Amigo / QuickGO
Orthologs
	80746
	381802
	ENSG00000154743
	ENSMUSG00000042389
	Q8NCE0
	Q6P7W5
NM_001145392 ; NM_001145393 ; NM_001145394 ; NM_001145395 ; NM_025265 ;
	NM_001321277 ; NM_001321278 ; NM_001321279
	NM_199033
NP_001138864 ; NP_001138865 ; NP_001138866 ; NP_001308206 ; NP_001308207 ;
	NP_001308208 ; NP_079541
	NP_950198
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

tRNA-splicing endonuclease subunit Sen2 is an enzyme that in humans is encoded by the TSEN2 gene.^[5]^[6]

Interactions

TSEN2 has been shown to interact with TSEN34 ^[5] and TSEN15.^[5]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000154743 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042389 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi: 10.1016/S0092-8674(04)00342-3 . PMID 15109492. S2CID 16049289.
1 2 "Entrez Gene: TSEN2 tRNA splicing endonuclease 2 homolog (S. cerevisiae)".

External links

GeneReviews/NCBI/NIH/UW entry on Pontocerebellar Hypoplasia Type 2 and Type 4

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID 15345747.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542 . PMID 12421765.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000154743 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042389 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15109492-5] 1 2 3 Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi: 10.1016/S0092-8674(04)00342-3 . PMID 15109492. S2CID 16049289.

[entrez-6] 1 2 "Entrez Gene: TSEN2 tRNA splicing endonuclease 2 homolog (S. cerevisiae)".

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TSEN2

Contents

Interactions

Related Research Articles

References

External links

Further reading