TSEN34

TSEN34
Identifiers
Aliases	TSEN34 , LENG5, PCH2C, SEN34, SEN34L, tRNA splicing endonuclease subunit 34
External IDs	OMIM: 608754; MGI: 1913328; HomoloGene: 44182; GeneCards: TSEN34; OMA:TSEN34 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.42 Start 54,189,938 bp [1] End 54,194,536 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 A1 Start 3,695,862 bp [2] End 3,704,023 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex gonad mucosa of transverse colon right ovary right uterine tube left ovary Top expressed in mesencephalon neural tube yolk sac epiblast placenta rhombencephalon ventricular zone stomach lip heart More reference expression data BioGPS n/a
Gene ontology Molecular function tRNA-intron endonuclease activity lyase activity nucleic acid binding nuclease activity Cellular component nucleolus nucleus tRNA-intron endonuclease complex nucleoplasm Biological process mRNA processing tRNA-type intron splice site recognition and cleavage RNA phosphodiester bond hydrolysis, endonucleolytic tRNA splicing, via endonucleolytic cleavage and ligation RNA phosphodiester bond hydrolysis tRNA processing nucleic acid phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79042 66078 Ensembl ENSG00000278622 ENSG00000274129 ENSG00000274796 ENSG00000278712 ENSG00000275165 ENSG00000278605 ENSG00000273896 ENSG00000274078 ENSG00000274672 ENSG00000170892 ENSMUSG00000035585 UniProt Q9BSV6 Q8BMZ5 RefSeq (mRNA) NM_001077446 NM_001282332 NM_001282333 NM_024075 NM_001386740 NM_001164204 NM_001164205 NM_024168 RefSeq (protein) NP_001070914 NP_001269261 NP_001269262 NP_076980 NP_001157676 NP_001157677 NP_077130 Location (UCSC) Chr 19: 54.19 – 54.19 Mb Chr 7: 3.7 – 3.7 Mb PubMed search [3] [4]
Wikidata
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tRNA-splicing endonuclease subunit Sen34 is an enzyme that in humans is encoded by the TSEN34 gene. ^{[5] [6] [7]}

tRNA splicing is a fundamental process required for cell growth and division. SEN34 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM] ^[7]

Interactions

TSEN34 has been shown to interact with TSEN2. ^[6]

References

1. ENSG00000274129, ENSG00000274796, ENSG00000278712, ENSG00000275165, ENSG00000278605, ENSG00000273896, ENSG00000274078, ENSG00000274672, ENSG00000170892 GRCh38: Ensembl release 89: ENSG00000278622, ENSG00000274129, ENSG00000274796, ENSG00000278712, ENSG00000275165, ENSG00000278605, ENSG00000273896, ENSG00000274078, ENSG00000274672, ENSG00000170892 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035585 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wende H, Volz A, Ziegler A (Sep 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID   10941842. S2CID   20719684.
6. Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi: 10.1016/S0092-8674(04)00342-3 . PMID   15109492. S2CID   16049289.
7. "Entrez Gene: TSEN34 tRNA splicing endonuclease 34 homolog (S. cerevisiae)".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.

External links

• GeneReviews/NCBI/NIH/UW entry on Pontocerebellar Hypoplasia Type 2 and Type 4