TSPYL2

TSPYL2
Identifiers
Aliases	TSPYL2 , CDA1, CINAP, CTCL, DENTT, HRIHFB2216, NP79, SE204, TSPX, TSPY-like 2, TSPY like 2
External IDs	OMIM: 300564; MGI: 106244; HomoloGene: 11140; GeneCards: TSPYL2; OMA:TSPYL2 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xp11.22 Start 53,082,367 bp [1] End 53,088,540 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X F3|X 68.46 cM Start 151,119,848 bp [2] End 151,125,421 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary right hemisphere of cerebellum left ovary right ovary right frontal lobe right testis left testis gastric mucosa tibial nerve left uterine tube Top expressed in neural layer of retina dorsomedial hypothalamic nucleus primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell paraventricular nucleus of hypothalamus ventromedial nucleus genital tubercle arcuate nucleus cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function rDNA binding protein binding Cellular component nucleolus nucleoplasm nucleus cytoplasm Biological process cell cycle nucleosome assembly IRE1-mediated unfolded protein response negative regulation of cell cycle negative regulation of DNA replication regulation of protein kinase activity regulation of transcription, DNA-templated regulation of signal transduction negative regulation of cell growth transcription, DNA-templated chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64061 52808 Ensembl ENSG00000184205 ENSMUSG00000041096 UniProt Q9H2G4 Q7TQI8 RefSeq (mRNA) NM_022117 NM_029836 NM_145936 NM_001358369 RefSeq (protein) NP_071400 NP_084112 NP_001345298 Location (UCSC) Chr X: 53.08 – 53.09 Mb Chr X: 151.12 – 151.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Testis-specific Y-encoded-like protein 2 is a protein that in humans is encoded by the TSPYL2 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000184205 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041096 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ozbun LL, You L, Kiang S, Angdisen J, Martinez A, Jakowlew SB (Apr 2001). "Identification of differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily". Genomics. 73 (2): 179–93. doi:10.1006/geno.2001.6505. PMID   11318608.
6. Chai Z, Sarcevic B, Mawson A, Toh BH (Sep 2001). "SET-related cell division autoantigen-1 (CDA1) arrests cell growth". J Biol Chem. 276 (36): 33665–74. doi: 10.1074/jbc.M007681200 . PMID   11395479.
7. "Entrez Gene: TSPYL2 TSPY-like 2".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Eichmuller S, Usener D, Dummer R, et al. (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. doi: 10.1073/pnas.021386498 . PMC   14639 . PMID   11149944.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wang GS, Hong CJ, Yen TY, et al. (2004). "Transcriptional modification by a CASK-interacting nucleosome assembly protein". Neuron. 42 (1): 113–28. doi: 10.1016/S0896-6273(04)00139-4 . PMID   15066269.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Santama N, Ogg SC, Malekkou A, et al. (2006). "Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus". J. Biol. Chem. 280 (43): 36429–41. doi: 10.1074/jbc.M501982200 . PMID   16079131.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569.
• Radke JR, Donald RG, Eibs A, et al. (2006). "Changes in the expression of human cell division autoantigen-1 influence Toxoplasma gondii growth and development". PLOS Pathog. 2 (10): e105. doi: 10.1371/journal.ppat.0020105 . PMC   1626100 . PMID   17069459.
• Tu Y, Wu W, Wu T, et al. (2007). "Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways". J. Biol. Chem. 282 (16): 11722–31. doi: 10.1074/jbc.M609623200 . PMID   17317670.