TSR2 (gene)

TSR2
Identifiers
Aliases	TSR2 , DT1P1A10, WGG1, DBA14, ribosome maturation factor, TSR2 ribosome maturation factor
External IDs	OMIM: 300945 MGI: 1916749 HomoloGene: 43235 GeneCards: TSR2
Gene location (Human)
Chr.	X chromosome (human)
End	54,448,032 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	149,879,539 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; putamen; ; amygdala; ; optic nerve; ; inferior olivary nucleus; ; nucleus accumbens; ; pons; ; hypothalamus; ; substantia nigra; ; middle temporal gyrus;
	Top expressed in
	Region I of hippocampus proper; ; primitive streak; ; arcuate nucleus; ; suprachiasmatic nucleus; ; substantia nigra; ; paraventricular nucleus of hypothalamus; ; ectoderm; ; otic placode; ; ventromedial nucleus; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ;
Cellular component	nucleus ;
Biological process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ; rRNA processing ;
	Sources:Amigo / QuickGO
Orthologs
	90121
	69499
	ENSG00000158526
	ENSMUSG00000025264
	Q969E8
	Q8C8T8
	NM_001346789 ; NM_001346790 ; NM_001346791 ; NM_001346792 ; NM_058163 Contents Function ; References ; Further reading ;
	NM_001164578 ; NM_175146
	NP_001333718 ; NP_001333719 ; NP_001333720 ; NP_001333721 ; NP_477511
	NP_001158050 ; NP_780355
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 01, 2022

TSR2 ribosome maturation factor is a protein that in humans is encoded by the TSR2 gene. ^[5]

Function

The protein encoded by this gene appears to repress the transcription of NF-kappaB and may be involved in apoptosis. Defects in this gene are a cause of Diamond-Blackfan anemia. [provided by RefSeq, Oct 2016].

Related Research Articles

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40S ribosomal protein S17 is a protein that in humans is encoded by the RPS17 gene.

<span class="mw-page-title-main">SBDS</span>

Ribosome maturation protein SBDS is a protein that in humans is encoded by the SBDS gene. An alternative transcript has been described, but its biological nature has not been determined. This gene has a closely linked pseudogene that is distally located. This gene encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants.

60S ribosomal protein L35a is a protein that in humans is encoded by the RPL35A gene.

60S ribosomal protein L18 is a protein that in humans is encoded by the RPL18 gene.

40S ribosomal protein S29 is a protein that in humans is encoded by the RPS29 gene.

60S ribosomal protein L38 is a protein that in humans is encoded by the RPL38 gene.

Translation initiation factor IF-2, mitochondrial is a protein that in humans is encoded by the MTIF2 gene.

Tumor necrosis factor receptor superfamily member 19L is a protein that in humans is encoded by the RELT gene.

Regulatory factor X, 6 also known as DNA-binding protein RFX6 is a protein that in humans is encoded by the RFX6 gene.

MAX dimerization protein 3 is a protein that in humans is encoded by the MXD3 gene located on Chromosome 5.

FAST kinase domain-containing protein 5 (FASTKD5) is a protein that in humans is encoded by the FASTKD5 gene on chromosome 20. This protein is part of the FASTKD family, which is known for regulating the energy balance of mitochondria under stress. FASTKD5 is also required for RNA granules to process precursor mRNAs not flanked by tRNAs.

Density regulated re-initiation and release factor (DENR) is a protein that in humans is encoded by the DENR gene.

FLT3 interacting zinc finger 1 is a protein that in humans is encoded by the FIZ1 gene.

Ribosome-releasing factor 2, mitochondrial is a protein that in humans is encoded by the GFM2 gene. Unlike the other EF-G homolog GFM1, GFM2 functions as a Ribosome Recycling Factor in termination.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000158526 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025264 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: TSR2 ribosome maturation factor" . Retrieved 2020-04-12.

TSR2 (gene)

Contents

Function

Related Research Articles

References

Further reading