TSTA3

Last updated
GFUS
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GFUS , FX, P35B, SDR4E1, tissue specific transplantation antigen P35B, TSTA3, GDP-L-fucose synthase
External IDs OMIM: 137020; MGI: 98857; HomoloGene: 2484; GeneCards: GFUS; OMA:GFUS - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003313
NM_001317783

NM_031201
NM_001357005

RefSeq (protein)

NP_001304712
NP_003304

NP_112478
NP_001343934

Location (UCSC) Chr 8: 143.61 – 143.62 Mb Chr 15: 75.8 – 75.8 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GDP-L-fucose synthetase is an enzyme that in humans is encoded by the TSTA3 gene. [5] [6] [7] [8]

Contents

Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [8]

References

  1. 1 2 3 ENSG00000278243 GRCh38: Ensembl release 89: ENSG00000104522, ENSG00000278243 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022570 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Camardella L, Carratore V, Ciardiello MA, Damonte G, Benatti U, De Flora A (Feb 1995). "Primary structure of human erythrocyte nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein FX: identification with the mouse tum- transplantation antigen P35B". Blood. 85 (1): 264–7. doi: 10.1182/blood.V85.1.264.bloodjournal851264 . PMID   7803801.
  6. Dyson PJ, de Smet C, Knight AM, Simon-Chazottes D, Guenet JL, Boon T (May 1992). "Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198". Immunogenetics. 35 (5): 316–23. doi:10.1007/bf00189894. PMID   1348494. S2CID   9048773.
  7. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC   2896744 . PMID   19027726.
  8. 1 2 "Entrez Gene: TSTA3 tissue specific transplantation antigen P35B".

Further reading