TTC3

TTC3
Identifiers
Aliases	TTC3 , DCRR1, RNF105, TPRDIII, tetratricopeptide repeat domain 3
External IDs	OMIM: 602259 MGI: 1276539 HomoloGene: 2487 GeneCards: TTC3
Gene location (Human)
Chr.	Chromosome 21 (human)
End	37,203,112 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	94,469,343 bp
RNA expression pattern
	Top expressed in
	prosencephalon; ; neocortex; ; pituitary gland; ; corpus callosum; ; cerebral cortex; ; nucleus accumbens;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	GO:0001948 protein binding ; metal ion binding ; ubiquitin-protein transferase activity ; transferase activity ;
Cellular component	nucleolus ; nucleus ; cytosol ;
Biological process	protein K48-linked ubiquitination ; protein ubiquitination ; ubiquitin-dependent protein catabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	7267
	22129
	ENSG00000182670
	ENSMUSG00000040785
	P53804
	O88196
NM_001001894 ; NM_003316 ; NM_001320703 ; NM_001320704 ; NM_001330681 ;
	NM_001330682 ; NM_001330683 ; NM_001353936 ; NM_001353937 ; NM_001353938
	NM_009441
NP_001001894 ; NP_001307632 ; NP_001307633 ; NP_001317610 ; NP_001317611 ;
	NP_001317612 ; NP_003307 ; NP_001340865 ; NP_001340866 ; NP_001340867
XP_011249721.1 ; XP_011249722.1 ; XP_011249724.1 ; XP_011249725.1 ; XP_011249730.1 ;
	XP_011249731.1 ; XP_011249732.1 ; XP_011249733.1
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 08, 2022

Tetratricopeptide repeat protein 3 is a protein that in humans is encoded by the TTC3 gene.^[5]^[6]

Related Research Articles

Chromosome 21 is one of the 23 pairs of chromosomes in humans. Chromosome 21 is both the smallest human autosome and chromosome, with 48 million base pairs representing about 1.5 percent of the total DNA in cells. Most people have two copies of chromosome 21, while those with three copies of chromosome 21 have Down syndrome, also called "trisomy 21".

RoXaN also known as ZC3H7B, is a protein that in humans is encoded by the ZC3H7B gene. RoXaN is a protein that contains tetratricopeptide repeat and leucine-aspartate repeat as well as zinc finger domains. This protein also interacts with the rotavirus non-structural protein NSP3.

ADGRV1, also known as G protein-coupled receptor 98 (GPR98) or Very Large G-protein coupled receptor 1 (VLGR1), is a protein that in humans is encoded by the GPR98 gene. Several alternatively spliced transcripts have been described.

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A is an enzyme that in humans is encoded by the DYRK1A gene. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

Interferon-induced protein with tetratricopeptide repeats 1 is a protein that in humans is encoded by the IFIT1 gene.

Sodium/myo-inositol cotransporter is a protein that in humans is encoded by the SLC5A3 gene.

Leucine-rich repeat-containing protein 48 is a protein that in humans is encoded by the LRRC48 gene.

39S ribosomal protein L40, mitochondrial is a protein that in humans is encoded by the MRPL40 gene.

Tetratricopeptide repeat protein 1 is a protein that in humans is encoded by the TTC1 gene.

Proteasome assembly chaperone 1 is a protein that in humans is encoded by the PSMG1 gene.

Tetratricopeptide repeat protein 35 is a protein that in humans is encoded by the TTC35 gene.

Subunit P of phosphatidylinositol N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the PIGP gene.

Guanine nucleotide-binding protein subunit beta-like protein 1 is a protein that in humans is encoded by the GNB1L gene.

DnaJ homolog subfamily C member 28 is a protein that in humans is encoded by the DNAJC28 gene. It's a member of chaperone DnaJ family. The family is also known as Hsp40.

SH3 domain-binding glutamic acid-rich protein is a protein that in humans is encoded by the SH3BGR gene.

Putative polypeptide N-acetylgalactosaminyltransferase-like protein 3 is an enzyme that in humans is encoded by the WBSCR17 gene.

Tetratricopeptide repeat protein 4 is a protein that in humans is encoded by the TTC4 gene.

Tetratricopeptide repeat protein 25 is a protein that in humans is encoded by the TTC25 gene.

Tetratricopeptide repeat domain 8 (TTC8) also known as Bardet–Biedl syndrome 8 is a protein that in humans is encoded by the TTC8 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000182670 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040785 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tsukahara F, Hattori M, Muraki T, Sakaki Y (Mar 1997). "Identification and cloning of a novel cDNA belonging to tetratricopeptide repeat gene family from Down syndrome-critical region 21q22.2". J Biochem. 120 (4): 820–7. doi:10.1093/oxfordjournals.jbchem.a021485. PMID 8947847.
↑ "Entrez Gene: TTC3 tetratricopeptide repeat domain 3".

Ohira M, Ootsuyama A, Suzuki E, et al. (1996). "Identification of a novel human gene containing the tetratricopeptide repeat domain from the Down syndrome region of chromosome 21". DNA Res. 3 (1): 9–16. doi: 10.1093/dnares/3.1.9 . PMID 8724848.
Eki T, Abe M, Naitou M, et al. (1997). "Cloning and characterization of novel gene, DCRR1, expressed from Down's syndrome critical region of human chromosome 21q22.2". DNA Seq. 7 (3–4): 153–64. doi:10.3109/10425179709034031. PMID 9254009.
Dahmane N, Ghezala GA, Gosset P, et al. (1998). "Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome". Genomics. 48 (1): 12–23. doi:10.1006/geno.1997.5146. PMID 9503011.
Rachidi M, Lopes C, Gassanova S, et al. (2000). "Regional and cellular specificity of the expression of TPRD, the tetratricopeptide Down syndrome gene, during human embryonic development". Mech. Dev. 93 (1–2): 189–93. doi: 10.1016/S0925-4773(00)00259-8 . PMID 10781955. S2CID 1109717.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi: 10.1038/35012518 . PMID 10830953.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Berto G, Camera P, Fusco C, et al. (2007). "The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase". J. Cell Sci. 120 (Pt 11): 1859–67. doi: 10.1242/jcs.000703 . PMID 17488780.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000182670 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040785 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8947847-5] Tsukahara F, Hattori M, Muraki T, Sakaki Y (Mar 1997). "Identification and cloning of a novel cDNA belonging to tetratricopeptide repeat gene family from Down syndrome-critical region 21q22.2". J Biochem. 120 (4): 820–7. doi:10.1093/oxfordjournals.jbchem.a021485. PMID 8947847.

[entrez-6] "Entrez Gene: TTC3 tetratricopeptide repeat domain 3".

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TTC3

Related Research Articles

References

Further reading