TTC4

TTC4
Identifiers
Aliases	TTC4 , tetratricopeptide repeat domain 4, CNS1
External IDs	OMIM: 606753; MGI: 1919604; HomoloGene: 31249; GeneCards: TTC4; OMA:TTC4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p32.3 Start 54,715,861 bp [1] End 54,742,657 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 C7 Start 106,519,453 bp [2] End 106,536,141 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle islet of Langerhans muscle of thigh skeletal muscle tissue C1 segment pituitary gland anterior pituitary testicle ventricular zone apex of heart Top expressed in spermatocyte spermatid neural layer of retina seminiferous tubule ventricular zone neural tube muscle of thigh right kidney superior frontal gyrus cerebellar cortex More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 7268 72354 Ensembl ENSG00000243725 ENSMUSG00000025413 UniProt O95801 Q8R3H9 RefSeq (mRNA) NM_004623 NM_001291333 NM_001172073 NM_028209 RefSeq (protein) NP_001278262 NP_004614 NP_001165544 NP_082485 Location (UCSC) Chr 1: 54.72 – 54.74 Mb Chr 4: 106.52 – 106.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tetratricopeptide repeat protein 4 is a protein that in humans is encoded by the TTC4 gene. ^{[5] [6]}

The 34-amino acid tetratricopeptide repeat (TPR) motif is found in a variety of proteins and may mediate protein-protein or protein-membrane interactions.[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000243725 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025413 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Su G, Roberts T, Cowell JK (Sep 1999). "TTC4, a novel human gene containing the tetratricopeptide repeat and mapping to the region of chromosome 1p31 that is frequently deleted in sporadic breast cancer". Genomics. 55 (2): 157–63. doi:10.1006/geno.1998.5633. PMID   9933562.
6. "Entrez Gene: TTC4 tetratricopeptide repeat domain 4".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Lan S, Wang H, Jiang H, et al. (2003). "Direct interaction between alpha-actinin and hepatitis C virus NS5B". FEBS Lett. 554 (3): 289–94. doi: 10.1016/S0014-5793(03)01163-3 . PMID   14623081.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hey Y, Brintnell B, James LA, Varley JM (2000). "Assignment of TTC4 to human chromosome band 1p31.3 and a pseudogene TTC4P to 7p14→p13 by in situ hybridization". Cytogenet. Cell Genet. 88 (3–4): 272–4. doi:10.1159/000015536. PMID   10828607. S2CID   34754868.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.