TTC4

TTC4
Identifiers
Aliases	TTC4 , tetratricopeptide repeat domain 4, CNS1
External IDs	OMIM: 606753 MGI: 1919604 HomoloGene: 31249 GeneCards: TTC4
Gene location (Human)
Chr.	Chromosome 1 (human)
End	54,742,657 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	106,536,141 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; islet of Langerhans; ; skeletal muscle tissue; ; pituitary gland; ; anterior pituitary; ; left ventricle; ; hypothalamus; ; caudate nucleus; ; Brodmann area 9; ; smooth muscle tissue;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; neural tube; ; superior frontal gyrus; ; cerebellar cortex; ; triceps brachii muscle; ; maxillary prominence; ; proximal tubule; ; sternocleidomastoid muscle;
	More reference expression data
	n/a
Orthologs
	7268
	72354
	ENSG00000243725
	ENSMUSG00000025413
	O95801
	Q8R3H9
	NM_004623 ; NM_001291333
	NM_001172073 ; NM_028209
	NP_001278262 ; NP_004614
	NP_001165544 ; NP_082485
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Tetratricopeptide repeat protein 4 is a protein that in humans is encoded by the TTC4 gene.^[5]^[6]

The 34-amino acid tetratricopeptide repeat (TPR) motif is found in a variety of proteins and may mediate protein-protein or protein-membrane interactions.[supplied by OMIM]^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000243725 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025413 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Su G, Roberts T, Cowell JK (Sep 1999). "TTC4, a novel human gene containing the tetratricopeptide repeat and mapping to the region of chromosome 1p31 that is frequently deleted in sporadic breast cancer". Genomics. 55 (2): 157–63. doi:10.1006/geno.1998.5633. PMID 9933562.
1 2 "Entrez Gene: TTC4 tetratricopeptide repeat domain 4".

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Lan S, Wang H, Jiang H, et al. (2003). "Direct interaction between alpha-actinin and hepatitis C virus NS5B". FEBS Lett. 554 (3): 289–94. doi: 10.1016/S0014-5793(03)01163-3 . PMID 14623081.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Hey Y, Brintnell B, James LA, Varley JM (2000). "Assignment of TTC4 to human chromosome band 1p31.3 and a pseudogene TTC4P to 7p14→p13 by in situ hybridization". Cytogenet. Cell Genet. 88 (3–4): 272–4. doi:10.1159/000015536. PMID 10828607. S2CID 34754868.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000243725 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025413 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9933562-5] Su G, Roberts T, Cowell JK (Sep 1999). "TTC4, a novel human gene containing the tetratricopeptide repeat and mapping to the region of chromosome 1p31 that is frequently deleted in sporadic breast cancer". Genomics. 55 (2): 157–63. doi:10.1006/geno.1998.5633. PMID 9933562.

[entrez-6] 1 2 "Entrez Gene: TTC4 tetratricopeptide repeat domain 4".

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TTC4

Related Research Articles

References

Further reading