TUSC2

TUSC2
Identifiers
Aliases	TUSC2 , C3orf11, FUS1, PAP, PDAP2, tumor suppressor candidate 2, tumor suppressor 2, mitochondrial calcium regulator
External IDs	OMIM: 607052 MGI: 1931086 HomoloGene: 5264 GeneCards: TUSC2
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p21.31 Start 50,320,027 bp [1] End 50,328,251 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 F1 Start 107,440,454 bp [2] End 107,443,311 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex cingulate gyrus Brodmann area 9 nucleus accumbens amygdala putamen caudate nucleus gastrocnemius muscle olfactory bulb pons Top expressed in superior frontal gyrus proximal tubule cerebellar cortex neural tube facial motor nucleus yolk sac lip temporal muscle intercostal muscle Region I of hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component mitochondrion Biological process regulation of mitochondrial membrane potential cell-cell signaling cell cycle chemokine (C-C motif) ligand 5 production cell population proliferation inflammatory response negative regulation of interleukin-17 production cell maturation neutrophil-mediated killing of gram-negative bacterium regulation of reactive oxygen species metabolic process defense response to Gram-negative bacterium interleukin-15 production positive regulation of interleukin-10 production phagocytosis natural killer cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11334 80385 Ensembl ENSG00000114383 ENSMUSG00000010054 UniProt O75896 Q9WVF8 RefSeq (mRNA) NM_007275 NM_019742 RefSeq (protein) NP_009206 NP_062716 Location (UCSC) Chr 3: 50.32 – 50.33 Mb Chr 9: 107.44 – 107.44 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tumor suppressor candidate 2 is a protein that in humans is encoded by the TUSC2 gene. ^{[5] [6] [7]}

This gene is a highly conserved lung cancer candidate gene. No other information about this gene is currently available. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000114383 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000010054 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fischer WH, Schubert D (Jan 1997). "Characterization of a novel platelet-derived growth factor-associated protein". J Neurochem. 66 (5): 2213–6. doi:10.1046/j.1471-4159.1996.66052213.x. PMID   8780057. S2CID   28782367.
6. Kondo M, Ji L, Kamibayashi C, Tomizawa Y, Randle D, Sekido Y, Yokota J, Kashuba V, Zabarovsky E, Kuzmin I, Lerman M, Roth J, Minna JD (Oct 2001). "Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells". Oncogene. 20 (43): 6258–62. doi:10.1038/sj.onc.1204832. PMID   11593436. S2CID   24352259.
7. "Entrez Gene: TUSC2 tumor suppressor candidate 2".

Further reading

• Prudkin L, Behrens C, Liu DD, et al. (2008). "Loss and reduction of FUS1 protein expression is a frequent phenomenon in the pathogenesis of lung cancer". Clin. Cancer Res. 14 (1): 41–7. doi:10.1158/1078-0432.CCR-07-1252. PMC   2833352 . PMID   18172250.
• Lee DY, Deng Z, Wang CH, Yang BB (2008). "MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression". Proc. Natl. Acad. Sci. U.S.A. 104 (51): 20350–5. doi: 10.1073/pnas.0706901104 . PMC   2154434 . PMID   18077375.
• Lin J, Sun T, Ji L, et al. (2007). "Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1". Oncogene. 26 (49): 6989–96. doi:10.1038/sj.onc.1210500. PMC   3457636 . PMID   17486070.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Uno F, Sasaki J, Nishizaki M, et al. (2004). "Myristoylation of the fus1 protein is required for tumor suppression in human lung cancer cells". Cancer Res. 64 (9): 2969–76. doi: 10.1158/0008-5472.CAN-03-3702 . PMID   15126327.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Lerman MI, Minna JD (2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res. 60 (21): 6116–33. PMID   11085536.