TXNL1

TXNL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GH2, 1WWY
Identifiers
Aliases	TXNL1 , HEL-S-114, TRP32, TXL-1, TXNL, Txl, thioredoxin like 1
External IDs	OMIM: 603049 MGI: 1860078 HomoloGene: 3515 GeneCards: TXNL1
Gene location (Human)
Chr.	Chromosome 18 (human)
End	56,651,600 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	63,841,872 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; endothelial cell; ; hair follicle; ; cavity of mouth; ; right ventricle; ; cancellous bone; ; biceps brachii; ; retinal pigment epithelium; ; middle temporal gyrus; ; sperm;
	Top expressed in
	endocardial cushion; ; atrioventricular valve; ; Paneth cell; ; fossa; ; condyle; ; abdominal wall; ; facial motor nucleus; ; lacrimal gland; ; dermis; ; vas deferens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	disulfide oxidoreductase activity ; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor ; thioredoxin-disulfide reductase activity ; protein-disulfide reductase activity ; protein-disulfide reductase (NAD(P)) activity ;
Cellular component	cytoplasm ; proteasome complex ; nucleus ; cytosol ;
Biological process	cellular response to oxidative stress ; cell redox homeostasis ; cellular oxidant detoxification ;
	Sources:Amigo / QuickGO
Orthologs
	9352
	53382
	ENSG00000091164
	ENSMUSG00000024583
	O43396
	Q8CDN6
	NM_004786
	NM_016792
	NP_004777
	NP_058072
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Thioredoxin-like protein 1 is a protein that in humans is encoded by the TXNL1 gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000091164 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024583 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Miranda-Vizuete A, Gustafsson JA, Spyrou G (Mar 1998). "Molecular cloning and expression of a cDNA encoding a human thioredoxin-like protein". Biochem Biophys Res Commun. 243 (1): 284–288. doi:10.1006/bbrc.1997.8003. PMID 9473519.
↑ Lee KK, Murakawa M, Takahashi S, Tsubuki S, Kawashima S, Sakamaki K, Yonehara S (Aug 1998). "Purification, molecular cloning, and characterization of TRP32, a novel thioredoxin-related mammalian protein of 32 kDa". J Biol Chem. 273 (30): 19160–19166. doi: 10.1074/jbc.273.30.19160 . PMID 9668102.
↑ "Entrez Gene: TXNL1 thioredoxin-like 1".

Miranda-Vizuete A, Spyrou G (2000). "Genomic structure and chromosomal localization of human thioredoxin-like protein gene (txl)". DNA Seq. 10 (6): 419–24. doi:10.3109/10425170009015613. hdl: 10261/47456 . PMID 10826702. S2CID 38627981.
Jin J, Chen X, Zhou Y, et al. (2002). "Crystal structure of the catalytic domain of a human thioredoxin-like protein". Eur. J. Biochem. 269 (8): 2060–2068. doi: 10.1046/j.1432-1033.2002.02844.x . PMID 11985582.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–569. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Kim KY, Lee JW, Park MS, et al. (2006). "Expression of a thioredoxin-related protein-1 is induced by prostaglandin E(2)". Int. J. Cancer. 118 (7): 1670–1679. doi: 10.1002/ijc.21572 . PMID 16231315. S2CID 21916723.
Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–1318. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.
Jiménez A, Pelto-Huikko M, Gustafsson JA, Miranda-Vizuete A (2006). "Characterization of human thioredoxin-like-1: potential involvement in the cellular response against glucose deprivation". FEBS Lett. 580 (3): 960–967. doi:10.1016/j.febslet.2006.01.025. hdl: 10261/46508 . PMID 16438969. S2CID 18655983.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000091164 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024583 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9473519-5] Miranda-Vizuete A, Gustafsson JA, Spyrou G (Mar 1998). "Molecular cloning and expression of a cDNA encoding a human thioredoxin-like protein". Biochem Biophys Res Commun. 243 (1): 284–288. doi:10.1006/bbrc.1997.8003. PMID 9473519.

[pmid9668102-6] Lee KK, Murakawa M, Takahashi S, Tsubuki S, Kawashima S, Sakamaki K, Yonehara S (Aug 1998). "Purification, molecular cloning, and characterization of TRP32, a novel thioredoxin-related mammalian protein of 32 kDa". J Biol Chem. 273 (30): 19160–19166. doi: 10.1074/jbc.273.30.19160 . PMID 9668102.

[entrez-7] "Entrez Gene: TXNL1 thioredoxin-like 1".

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TXNL1

Related Research Articles

References

Further reading