Tetrahydrocoptisine

Last updated
Tetrahydrocoptisine
Tetrahydrocoptisine.svg
Names
Other names
Stylopine
Identifiers
3D model (JSmol)
ChemSpider
PubChem CID
UNII
  • C1CN2CC3=C(CC2C4=CC5=C(C=C41)OCO5)C=CC6=C3OCO6
Properties
C19H17NO4
Molar mass 323.348 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Tetrahydrocoptisine (also known as stylopine) is an alkaloid isolated from Corydalis impatiens . [1]

Related Research Articles

<i>Impatiens</i> Genus of flowering plants

Impatiens is a genus of more than 1,000 species of flowering plants, widely distributed throughout the Northern Hemisphere and the tropics. Together with the genus Hydrocera, Impatiens make up the family Balsaminaceae.

Papaveraceae Family of flowering plants

The Papaveraceae are an economically important family of about 42 genera and approximately 775 known species of flowering plants in the order Ranunculales, informally known as the poppy family. The family is cosmopolitan, occurring in temperate and subtropical climates, but almost unknown in the tropics. Most are herbaceous plants, but a few are shrubs and small trees. The family currently includes two groups that have been considered to be separate families: Fumariaceae and Pteridophyllaceae.

<i>Impatiens walleriana</i> Species of flowering plant

Impatiens walleriana, also known as busy Lizzie, balsam, sultana, or simply impatiens, is a species of the genus Impatiens, native to eastern Africa from Kenya to Mozambique. The Latin specific epithet walleriana honours a British missionary, Horace Waller (1833–1896).

<i>Impatiens glandulifera</i> Species of plant

Impatiens glandulifera, Himalayan balsam, is a large annual plant native to the Himalayas. Via human introduction it is now present across much of the Northern Hemisphere and is considered an invasive species in many areas. Uprooting or cutting the plants is an effective means of control.

<i>Corydalis</i> Genus of flowering plants in the poppy family Papaveraceae

Corydalis is a genus of about 470 species of annual and perennial herbaceous plants in the family Papaveraceae, native to the temperate Northern Hemisphere and the high mountains of tropical eastern Africa. They are most diverse in China and the Himalayas, with at least 357 species in China.

Balsaminaceae Family of flowering plants

The Balsaminaceae are a family of dicotyledonous plants, comprising two genera: Impatiens, which consists of 1000+ species, and Hydrocera, consisting of 1 species. The flowering plants may be annual or perennial. They are found throughout temperate and tropical regions, primarily in Asia and Africa, but also North America and Europe.

<i>Impatiens balsamina</i> Species of flowering plant in the family Balsaminaceae

Impatiens balsamina, commonly known as balsam, garden balsam, rose balsam, touch-me-not or spotted snapweed, is a species of plant native to India and Myanmar.

<i>Orthotospovirus</i> Genus of viruses

Orthotospovirus is a genus of negative-strand RNA viruses, in the family Tospoviridae of the order Bunyavirales, which infects plants. Tospoviruses take their name from the species Tomato spotted wilt orthotospovirus (TSWV) which was discovered in Australia in 1919. TSWV remained the only known member of the family until the early 1990s when genetic characterisation of plant viruses became more common. There are now at least twenty species in the genus with more being discovered on a regular basis. Member viruses infect over eight hundred plant species from 82 different families.

<i>Corydalis ambigua</i> Species of flowering plants in the poppy family Papaveraceae

Corydalis ambigua is a tuberous early flowering east Asian flowering plant species in the poppy family Papaveraceae. Its exact native range is obscure due to taxonomic confusion. It is one of the sources of the drug tetrahydropalmatine.

Tetrahydropalmatine

Tetrahydropalmatine (THP) is an isoquinoline alkaloid found in several different plant species, mainly in the genus Corydalis, but also in other plants such as Stephania rotunda. These plants have traditional uses in Chinese herbal medicine. The pharmaceutical industry has synthetically produced the more potent enantiomer Levo-tetrahydropalmatine (Levo-THP), which has been marketed worldwide under different brand names as an alternative to anxiolytic and sedative drugs of the benzodiazepine group and analgesics such as opiates. It is also sold as a dietary supplement.

Nantenine

Nantenine is an alkaloid found in the plant Nandina domestica as well as some Corydalis species. It is an antagonist of both the α1-adrenergic receptor and the serotonin 5-HT2A receptor, and blocks both the behavioral and physiological effects of MDMA in animals.

<i>Bombus impatiens</i> Species of insect

Bombus impatiens, the common eastern bumble bee, is the most commonly encountered bumblebee across much of eastern North America. They can be found in the Eastern temperate forest region of the eastern United States, southern Canada, and the eastern Great Plains. Because of their great adaptability, they can live in country, suburbs, and even urban cities. This adaptability makes them a great pollinator species, leading to an increase in their commercial use by greenhouse industry. This increase consequently led to their farther spread outside their previous distribution range. They are considered one of the most important species of pollinator bees in North America.

Lady Joan Margaret Legge (1885–1939) was a botanist from England who died on 4 July 1939 while collecting samples at Valley of flowers, India.

Sibiricine Chemical compound

Sibiricine is a bioactive isoquinoline alkaloid isolated from Corydalis crispa (Fumariaceae), which is a Bhutanese medicinal plant from the Himalayas.

Corydaline Chemical compound

Corydaline is an acetylcholinesterase inhibitor isolated from Corydalis yanhusuo.

Corynoline Chemical compound

Corynoline is an acetylcholinesterase inhibitor isolated from Corydalis incisa.

Corydalis yanhusuo is a plant species in the genus Corydalis. The Chinese name for Corydalis yanhusuo is yan hu suo. The Japanese common name is engosaku (エンゴサク) and the Korean common name is hyeonhosaek (현호색). English common names include yanhusuo, corydalis, and Asian corydalis. The tuber of this plant, frequently mislabeled as the root, is an important therapeutic agent in traditional Chinese medicine. It is native to high-altitude grasslands across China including in the provinces of Anhui, Henan, Hubei, Hunan, Jiangsu, and Zhejiang, but is more widely cultivated.

Sphaerisporangium is a Gram-positive genus of bacteria from the family of Streptosporangiaceae.

References

  1. Li, W.; Huang, H.; Zhang, Y.; Fan, T.; Liu, X.; Xing, W.; Niu, X. (2013). "Anti-inflammatory effect of tetrahydrocoptisine from Corydalis impatiens is a function of possible inhibition of TNF-α, IL-6 and NO production in lipopolysaccharide-stimulated peritoneal macrophages through inhibiting NF-κB activation and MAPK pathway". European Journal of Pharmacology. 715 (1–3): 62–71. doi:10.1016/j.ejphar.2013.06.017. PMID   23810685.