Deep brain stimulation (DBS) is a surgical procedure that implants a neurostimulator and electrodes which sends electrical impulses to specified targets in the brain responsible for movement control. The treatment is designed for a range of movement disorders such as Parkinson's disease, essential tremor, and dystonia, as well as for certain neuropsychiatric conditions like obsessive-compulsive disorder (OCD) and epilepsy. The exact mechanisms of DBS are complex and not entirely clear, but it is known to modify brain activity in a structured way.
Wilder Graves Penfield was an American-Canadian neurosurgeon. He expanded brain surgery's methods and techniques, including mapping the functions of various regions of the brain such as the cortical homunculus. His scientific contributions on neural stimulation expand across a variety of topics including hallucinations, illusions, dissociation and déjà vu. Penfield devoted much of his thinking to mental processes, including contemplation of whether there was any scientific basis for the existence of the human soul.
Kenneth Milton Grimwood was an American author, who also published work under the name of Alan Cochran. In his fantasy fiction, Grimwood combined themes of life-affirmation and hope with metaphysical concepts, themes found in his best-known novel, Replay (1986). It won the 1988 World Fantasy Award for Best Novel.
In the anatomy of the brain, the centromedian nucleus, also known as the centrum medianum, is a nucleus in the posterior group of the intralaminar thalamic nuclei (ITN) in the thalamus. There are two centromedian nuclei arranged bilaterally.
A thalamic stimulator is a medical device that can suppress tremors, such as those caused by Parkinson's disease or essential tremor. It was approved for use by the Food and Drug Administration (FDA) on August 4, 1997. Installation is invasive, so it is typically only used when the tremors are incapacitating, and medication is ineffective. Typically, one or more electrodes are implanted in the brain, with subcutaneous leads to a neurostimulator, which may also be implanted. The electrodes stimulate the area of the thalamus, specifically the part of the brain that controls movement and muscle function.
Brain implants, often referred to as neural implants, are technological devices that connect directly to a biological subject's brain – usually placed on the surface of the brain, or attached to the brain's cortex. A common purpose of modern brain implants and the focus of much current research is establishing a biomedical prosthesis circumventing areas in the brain that have become dysfunctional after a stroke or other head injuries. This includes sensory substitution, e.g., in vision. Other brain implants are used in animal experiments simply to record brain activity for scientific reasons. Some brain implants involve creating interfaces between neural systems and computer chips. This work is part of a wider research field called brain–computer interfaces.
Neuroprosthetics is a discipline related to neuroscience and biomedical engineering concerned with developing neural prostheses. They are sometimes contrasted with a brain–computer interface, which connects the brain to a computer rather than a device meant to replace missing biological functionality.
Wireheading is a term associated with fictional or futuristic applications of brain stimulation reward, the act of directly triggering the brain's reward center by electrical stimulation of an inserted wire, for the purpose of 'short-circuiting' the brain's normal reward process and artificially inducing pleasure. Scientists have successfully performed brain stimulation reward on rats (1950s) and humans (1960s). This stimulation does not appear to lead to tolerance or satiation in the way that sex or drugs do. The term is sometimes associated with science fiction writer Larry Niven, who used the term in his Known Space series. In the philosophy of artificial intelligence, the term is used to refer to AI systems that hack their own reward channel.
Vagus nerve stimulation (VNS) is a medical treatment that involves delivering electrical impulses to the vagus nerve. It is used as an add-on treatment for certain types of intractable epilepsy, cluster headaches, treatment-resistant depression and stroke rehabilitation.
Electrocorticography (ECoG), a type of intracranial electroencephalography (iEEG), is a type of electrophysiological monitoring that uses electrodes placed directly on the exposed surface of the brain to record electrical activity from the cerebral cortex. In contrast, conventional electroencephalography (EEG) electrodes monitor this activity from outside the skull. ECoG may be performed either in the operating room during surgery or outside of surgery. Because a craniotomy is required to implant the electrode grid, ECoG is an invasive procedure.
The Terminal Man is a 1974 American horror science fiction film directed by Mike Hodges, based on the 1972 novel of the same name by Michael Crichton. Starring George Segal, the film centers on a man, who after suffering brain damage in a car crash, becomes violent during seizures. To solve the problem doctors implant a microcomputer designed to stop the seizures and thus the violent attacks. However the stimulus triggers the pleasure Center of the brain and cannot be turned off resulting in creating a homicidal killer.
Stereoelectroencephalography (SEEG) is the practice of recording electroencephalographic signals via depth electrodes. It may be used in patients with epilepsy not responding to medical treatment, and who are potential candidates to receive brain surgery in order to control seizures.
Epilepsy surgery involves a neurosurgical procedure where an area of the brain involved in seizures is either resected, ablated, disconnected or stimulated. The goal is to eliminate seizures or significantly reduce seizure burden. Approximately 60% of all people with epilepsy have focal epilepsy syndromes. In 15% to 20% of these patients, the condition is not adequately controlled with anticonvulsive drugs. Such patients are potential candidates for surgical epilepsy treatment.
Racine stages are a categorization of rodent epileptic seizures proposed by Ronald J. Racine in 1972. Prior to Racine's research in animal epilepsy models, a quantifiable means to describe seizure intensities and their causes was not readily available. Racine's work allowed for studies among different laboratories to be compared and understood more clearly.
Robert Galbraith Heath was an American psychiatrist. He followed the theory of biological psychiatry, which holds that organic defects are the sole source of mental illness, and that consequently mental problems are treatable by physical means. He published 425 papers and three books. One of his first papers is dated 1946. He was profiled as a "famous American psychiatrist" in 1983 by Psychiatric Annals.
Electrical brain stimulation (EBS), also referred to as focal brain stimulation (FBS), is a form of electrotherapy used as a technique in research and clinical neurobiology to stimulate a neuron or neural network in the brain through the direct or indirect excitation of its cell membrane by using an electric current. EBS is used for research or for therapeutic purposes.
Neurostimulation is the purposeful modulation of the nervous system's activity using invasive or non-invasive means. Neurostimulation usually refers to the electromagnetic approaches to neuromodulation.
Neuromodulation is "the alteration of nerve activity through targeted delivery of a stimulus, such as electrical stimulation or chemical agents, to specific neurological sites in the body". It is carried out to normalize – or modulate – nervous tissue function. Neuromodulation is an evolving therapy that can involve a range of electromagnetic stimuli such as a magnetic field (rTMS), an electric current, or a drug instilled directly in the subdural space. Emerging applications involve targeted introduction of genes or gene regulators and light (optogenetics), and by 2014, these had been at minimum demonstrated in mammalian models, or first-in-human data had been acquired. The most clinical experience has been with electrical stimulation.
A peripheral nerve interface is the bridge between the peripheral nervous system and a computer interface which serves as a bi‐directional information transducer recording and sending signals between the human body and a machine processor. Interfaces to the nervous system usually take the form of electrodes for stimulation and recording, though chemical stimulation and sensing are possible. Research in this area is focused on developing peripheral nerve interfaces for the restoration of function following disease or injury to minimize associated losses. Peripheral nerve interfaces also enable electrical stimulation and recording of the peripheral nervous system to study the form and function of the peripheral nervous system. For example, recent animal studies have demonstrated high accuracy in tracking physiological meaningful measures, like joint angle. Many researchers also focus in the area of neuroprosthesis, linking the human nervous system to bionics in order to mimic natural sensorimotor control and function. Successful implantation of peripheral nerve interfaces depend on a number of factors which include appropriate indication, perioperative testing, differentiated planning, and functional training. Typically microelectrode devices are implanted adjacent to, around or within the nerve trunk to establish contact with the peripheral nervous system. Different approaches may be used depending on the type of signal desired and attainable.
Neural dust is a hypothetical class of nanometer-sized devices operated as wirelessly powered nerve sensors; it is a type of brain–computer interface. The sensors may be used to study, monitor, or control the nerves and muscles and to remotely monitor neural activity. In practice, a medical treatment could introduce thousands of neural dust devices into human brains. The term is derived from "smart dust", as the sensors used as neural dust may also be defined by this concept.
