Thomas Kilduff

Thomas Kilduff
Alma mater	University of Florida Stanford University
Known for	Discovery of hypocretin
Awards	2009 AAAS Fellow
Scientific career
Fields	Neuroscience, particularly the neurobiology of sleep and wakefulness
Institutions	Ames Research Center Stanford University School of Medicine SRI International
Academic advisors	Wilse B. Webb, Craig Heller, Bill A. Williams, William C. Dement

Thomas S. Kilduff is an American neuroscientist and the director of SRI International's Center for Neuroscience. He specializes in neurobiology related to sleep and wakefulness, and was involved in the discovery of hypocretin (also known as orexin), ^{[1] [2]} a neuropeptide system that is highly involved in wakefulness regulation. ^{[3] [4] [5]}

His group at SRI International also discovered an unusual neuronal population in the cerebral cortex that is activated during sleep. ^{[6] [7] [8]}

He is also a consulting professor at the Stanford University School of Medicine's Department of Psychiatry and Behavioral Sciences. ^[3]

Education

Kilduff obtained a B.S. from the University of Florida and earned an M.S. and a Ph.D. in biological sciences from Stanford University, where he was also awarded fellowships from the Danforth Foundation, the Grass Foundation, and the National Science Foundation. ^[9]

Career

Kilduff was a senior research scientist at Stanford University's Center for Sleep and Circadian Neurobiology. ^[9] He was also a visiting scientist in the Scripps Research Institute's Department of Molecular Biology, a visiting professor at the University of Perugia's Istituto di Biologia Cellulare, and a National Academy of Sciences National Research Council research associate at NASA's Ames Research Center. ^[10]

In 1999, Kilduff joined SRI International as part of a new molecular neurobiology group, where he subsequently founded the Sleep Neurobiology Program before becoming director of the Center for Neuroscience. ^{[10] [11]}

Research

Kilduff's early research focused on the neural control of mammalian hibernation ^{[12] [13] [14]} and circadian rhythms. ^{[15] [16] [17]}

Kilduff and scientists at the Scripps Research Institute co-discovered hypocretin (also known as orexin), a neuropeptide system that is involved in the control of wakefulness. ^[11] Subsequent research established that the hypocretin neurons degenerate in the sleep disorder narcolepsy and is the likely cause of this disorder. ^{[18] [19]}

Awards and memberships

He was named a Fellow Member of the American Association for the Advancement of Science in the December 18, 2009 issue of Science . ^{[9] [20]} He was named an SRI Fellow in 2010 ^[3] and a Distinguished Scientist by the SRS in 2017. ^[21]

He is a member of the Society for Neuroscience has served on the boards of the Associated Professional Sleep Societies, the Sleep Research Society, and was a Founding Member of the Sleep Research Society Foundation. ^{[11] [22]}

See also

• Neuroscience of sleep

References

1. de Lecea, L.; Kilduff, T.S.; Peyron, C.; Gao, X.-B.; Foye, P.E.; Danielson, P.E.; Fukuhara, C.; Battenberg, E.L.F.; Gautvik, V.T.; Bartlett II, F.S.; et al. (1998). "The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity". Proceedings of the National Academy of Sciences USA . 95 (1, number 1): 322–327. Bibcode:1998PNAS...95..322D. doi: 10.1073/pnas.95.1.322 . PMC   18213 . PMID   9419374.
2. Sakurai, T.; Amemiya, A.; Ishii, M.; Matsuzaki, I.; Chemelli, R.M.; Tanaka, H.; Williams, S.C.; Richardson, J.A.; Kozlowski, G.P.; Wilson, S.; et al. (1998). "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior". Cell . 92 (4, number 4): 573–585. doi: 10.1016/S0092-8674(00)80949-6 . PMID   9491897. S2CID   16294729.
3. "Our People: Thomas Kilduff". SRI International . Retrieved 2013-04-28.
4. Thomas S. Kilduff; Ed S. Lein; Horacio de la Iglesia; Takeshi Sakurai; Ying-hui Fu & Paul Shaw (2008-11-12). "New Developments in Sleep Research: Molecular Genetics, Gene Expression, and Systems Neurobiology". The Journal of Neuroscience . 28 (46): 11814–11818. doi:10.1523/jneurosci.3768-08.2008. PMC   2628168 . PMID   19005045.
5. Kilduff, T.S. & Peyron, C. (2000). "The hypocretin/orexin ligand-receptor system: Implications for sleep and sleep disorders". Trends in Neurosciences. 23 (8, number 8): 359–365. doi: 10.1016/s0166-2236(00)01594-0 . PMID   10906799. S2CID   37955645.
6. "SRI International Research Team Identifies Rare Sleep-Activated Neurons in the Cerebral Cortex". SRI International. 2008-07-21. Retrieved 2013-06-15.
7. Gerashchenko, D.; Wisor, J.P.; Burns, D.; Reh, R.K.; Shiromani, P.J.; Sakurai, T.; de la Iglesia, H.O. & Kilduff, T.S (2008). "Identification of a population of sleep-active cerebral cortex neurons". Proceedings of the National Academy of Sciences USA . 105 (29): 10227–10232. Bibcode:2008PNAS..10510227G. doi: 10.1073/pnas.0803125105 . PMC   2481371 . PMID   18645184.
8. Kilduff, T.S.; Cauli, B. & Gerashchenko, D. (2011). "Activation of cortical interneurons during sleep: an anatomical link to homeostatic sleep regulation?". Trends in Neurosciences. 34 (1, number 1): 10–19. doi:10.1016/j.tins.2010.09.005. PMC   3014438 . PMID   21030095.
9. "SRI International Researcher Named American Association for the Advancement of Science (AAAS) Fellow". SRI International. 2010-01-20. Retrieved 2013-04-28.
10. "Stanford Scientist Thomas Kilduff Joins SRI International as Senior Program Director of Newly Formed Molecular Neurology Group". SRI International. 1999-01-25. Archived from the original on 2000-07-09. Retrieved 2013-04-28.
11. "Candidate: President Elect: Thomas Kilduff, PhD" (PDF). Sleep Research Society . Retrieved 2013-04-20.
12. Kilduff TS, Bowersox SS, Faull KF, et al. (1987). "Modulation of activity of the striatal dopaminergic system during the hibernation cycle". Neuroscience . 7 (9): 2732–2736. doi: 10.1523/JNEUROSCI.07-09-02732.1987 . PMC   6569135 . PMID   3625271.
13. Kilduff TS, Miller JD, Radeke CM, Sharp FR, Heller HC (1990). "14C-2-deoxyglucose uptake in the ground squirrel brain during entrance to and arousal from hibernation". Neuroscience . 10 (7): 2463–2475. doi: 10.1523/JNEUROSCI.10-07-02463.1990 . PMC   6570375 . PMID   2376782.
14. Kilduff TS, Sharp FR, Heller HC (1982). "[14C]2-deoxyglucose uptake in ground squirrel brain during hibernation". Neuroscience . 2 (2): 143–157. doi: 10.1523/JNEUROSCI.02-02-00143.1982 . PMC   6564310 . PMID   6278102.
15. Kilduff TS, Vugrinic C, Lee SL, et al. (1998). "Characterization of the circadian system of NGFI-A and NGFI-A/NGFI-B deficient mice". Journal of Biological Rhythms . 13 (4): 347–357. doi:10.1177/074873098129000174. PMID   9711509. S2CID   7759470.
16. Sutin EL, Dement WC, Heller HC, Kilduff TS (1993). "Light-induced gene expression in the suprachiasmatic nucleus of young and aging rats". Neurobiology of Aging . 14 (5): 441–446. doi:10.1016/0197-4580(93)90102-H. PMID   8247226. S2CID   4044038.
17. Sutin EL, Kilduff TS (1992). "Circadian and light-induced expression of immediate early gene mRNAs in the rat suprachiasmatic nucleus". Molecular Brain Research . 15 (3–4): 281–290. doi:10.1016/0169-328X(92)90119-V. PMID   1331682.
18. Peyron, C.; Faraco, J.; Rogers, W.; Ripley, B.; Overeem, S.; Charnay, Y.; Nevsimalova, S.; Aldrich, M.; Reynolds, D.; Albin, R.; et al. (2000). "A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains". Nature Medicine . 6 (9, number 9): 991–997. doi:10.1038/79690. PMID   10973318. S2CID   18076282.
19. Thannickal, T.; Moore, R.; Y., Nienhuis; R., Ramanathan; L., Gulyani; S., Aldrich; M., Cornford, M. & Siegel, J.M. (2000). "Reduced number of hypocretin neurons in human narcolepsy". Neuron . 27 (3, number 3): 469–474. doi: 10.1016/s0896-6273(00)00058-1 . PMC   8760623 . PMID   11055430. S2CID   5961605.
20. "Fellows". American Association for the Advancement of Science . Retrieved 2013-04-28.
21. "Distinguished Scientist Award". Sleep Research Society.
22. "Thomas Kilduff". Frontiers. Retrieved 2013-07-28.