Thrombospondin 3

Last updated
THBS3
Identifiers
Aliases THBS3 , TSP3, thrombospondin 3
External IDs OMIM: 188062 MGI: 98739 HomoloGene: 5159 GeneCards: THBS3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252607
NM_001252608
NM_007112

NM_013691

RefSeq (protein)

NP_001239536
NP_001239537
NP_009043

NP_038719

Location (UCSC) Chr 1: 155.2 – 155.21 Mb Chr 3: 89.22 – 89.23 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Thrombospondin-3 (TSP3) is a protein that in humans is encoded by the THBS3 gene. [5] [6]

The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. TSP3 has been found to be involved in the regulation of skeletal maturation. [7] This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. [6] Identified as the gene on chromosome 1 responsible for mediating an associated with genetic susceptibility to SARS-CoV-2 infection. [8]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000169231 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028047 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Vos HL, Devarayalu S, de Vries Y, Bornstein P (Jul 1992). "Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family". J Biol Chem. 267 (17): 12192–6. doi: 10.1016/S0021-9258(19)49823-2 . PMID   1601886.
  6. 1 2 "Entrez Gene: THBS3 thrombospondin 3".
  7. Hankenson, Kurt (July 2005). "Mice with a Disruption of the Thrombospondin 3 Gene Differ in Geometric and Biomechanical Properties of Bone and Have Accelerated Development of the Femoral Head". Molecular and Cellular Biology. 25 (13): 5599–5606. doi:10.1128/MCB.25.13.5599-5606.2005. PMC   1156967 . PMID   15964815.
  8. "Mapping the human genetic architecture of COVID-19". Nature. July 2021. doi:10.1038/s41586-021-03767-x. PMID   34237774. S2CID   235776838.

Further reading