Thrombospondin 3

THBS3
Identifiers
Aliases	THBS3 , TSP3, thrombospondin 3
External IDs	OMIM: 188062 MGI: 98739 HomoloGene: 5159 GeneCards: THBS3
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q22 Start 155,195,588 bp [1] End 155,209,051 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 F1|3 39.01 cM Start 89,215,180 bp [2] End 89,226,837 bp [2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • heparin binding • extracellular matrix structural constituent Cellular component • perinuclear region of cytoplasm • extracellular region • extracellular matrix • extracellular • collagen-containing extracellular matrix Biological process • growth plate cartilage development • ossification involved in bone maturation • cell-matrix adhesion • cell adhesion • bone trabecula formation • extracellular matrix organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7059	21827
Ensembl	ENSG00000169231	ENSMUSG00000028047
UniProt	P49746	Q05895
RefSeq (mRNA)	NM_001252607 NM_001252608 NM_007112	NM_013691
RefSeq (protein)	NP_001239536 NP_001239537 NP_009043	NP_038719
Location (UCSC)	Chr 1: 155.2 – 155.21 Mb	Chr 3: 89.22 – 89.23 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Thrombospondin-3 (TSP3) is a protein that in humans is encoded by the THBS3 gene. ^{[5] [6]}

The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. TSP3 has been found to be involved in the regulation of skeletal maturation. ^[7] This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000169231 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028047 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vos HL, Devarayalu S, de Vries Y, Bornstein P (Jul 1992). "Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family". J Biol Chem. 267 (17): 12192–6. PMID   1601886.
6. "Entrez Gene: THBS3 thrombospondin 3".
7. Hankenson, Kurt (July 2005). "Mice with a Disruption of the Thrombospondin 3 Gene Differ in Geometric and Biomechanical Properties of Bone and Have Accelerated Development of the Femoral Head". Molecular and Cellular Biology. 25 (13): 5599–5606. doi:10.1128/MCB.25.13.5599-5606.2005. PMC   1156967 . PMID   15964815 . Retrieved 24 February 2015.

Further reading

• O'Rourke KM, Laherty CD, Dixit VM (1993). "Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers". J. Biol. Chem. 267 (35): 24921–4. PMID   1459996.
• Adolph KW, Long GL, Winfield S, et al. (1995). "Structure and organization of the human thrombospondin 3 gene (THBS3)". Genomics. 27 (2): 329–36. doi:10.1006/geno.1995.1050. PMID   7558000.
• Qabar A, Derick L, Lawler J, Dixit V (1995). "Thrombospondin 3 is a pentameric molecule held together by interchain disulfide linkage involving two cysteine residues". J. Biol. Chem. 270 (21): 12725–9. doi: 10.1074/jbc.270.21.12725 . PMID   7759526.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Qabar AN, Lin Z, Wolf FW, et al. (1994). "Thrombospondin 3 is a developmentally regulated heparin binding protein". J. Biol. Chem. 269 (2): 1262–9. PMID   8288588.
• Bornstein P, Devarayalu S, Edelhoff S, Disteche CM (1993). "Isolation and characterization of the mouse thrombospondin 3 (Thbs3) gene". Genomics. 15 (3): 607–13. doi:10.1006/geno.1993.1114. PMID   8468055.
• Winfield SL, Tayebi N, Martin BM, et al. (1997). "Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease". Genome Res. 7 (10): 1020–6. doi:10.1101/gr.7.10.1020. PMC   310674 . PMID   9331372.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Adolph KW (1999). "Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues". Biochem. Biophys. Res. Commun. 258 (3): 792–6. doi:10.1006/bbrc.1999.0710. PMID   10329465.
• Adolph KW, Bornstein P (2000). "The human thrombospondin 3 gene: analysis of transcription initiation and an alternatively spliced transcript". Mol. Cell Biol. Res. Commun. 2 (1): 47–52. doi:10.1006/mcbr.1999.0148. PMID   10527891.
• Carron JA, Hiscott P, Hagan S, et al. (2001). "Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4". Int. J. Biochem. Cell Biol. 32 (11–12): 1137–42. doi:10.1016/S1357-2725(00)00065-0. PMID   11137453.
• Armstrong DJ, Hiscott P, Batterbury M, Kaye S (2002). "Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype". Int. J. Biochem. Cell Biol. 34 (6): 588–93. doi:10.1016/S1357-2725(01)00157-1. PMID   11943589.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Dalla-Torre CA, Yoshimoto M, Lee CH, et al. (2006). "Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma". BMC Cancer. 6: 237. doi:10.1186/1471-2407-6-237. PMC   1609181 . PMID   17022822.