Thrombospondin 3

THBS3
Identifiers
Aliases	THBS3 , TSP3, thrombospondin 3
External IDs	OMIM: 188062 MGI: 98739 HomoloGene: 5159 GeneCards: THBS3
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q22 Start 155,195,588 bp [1] End 155,209,051 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 F1|3 39.01 cM Start 89,122,487 bp [2] End 89,134,144 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube tibia right coronary artery left uterine tube tibial nerve canal of the cervix ascending aorta left coronary artery anterior pituitary gastric mucosa Top expressed in spermatocyte lip ankle right lung lobe Ankle joint esophagus spermatid uterus belly cord superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding heparin binding extracellular matrix structural constituent Cellular component perinuclear region of cytoplasm extracellular region extracellular matrix extracellular space collagen-containing extracellular matrix Biological process growth plate cartilage development ossification involved in bone maturation cell-matrix adhesion cell adhesion bone trabecula formation extracellular matrix organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7059 21827 Ensembl ENSG00000169231 ENSMUSG00000028047 UniProt P49746 Q05895 RefSeq (mRNA) NM_001252607 NM_001252608 NM_007112 NM_013691 RefSeq (protein) NP_001239536 NP_001239537 NP_009043 NP_038719 Location (UCSC) Chr 1: 155.2 – 155.21 Mb Chr 3: 89.12 – 89.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Thrombospondin-3 (TSP3) is a protein that in humans is encoded by the THBS3 gene. ^{[5] [6]}

The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. TSP3 has been found to be involved in the regulation of skeletal maturation. ^[7] This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. ^[6] Identified as the gene on chromosome 1 responsible for mediating an associated with genetic susceptibility to SARS-CoV-2 infection. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000169231 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028047 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vos HL, Devarayalu S, de Vries Y, Bornstein P (Jul 1992). "Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family". J Biol Chem. 267 (17): 12192–6. doi: 10.1016/S0021-9258(19)49823-2 . PMID   1601886.
6. "Entrez Gene: THBS3 thrombospondin 3".
7. Hankenson, Kurt (July 2005). "Mice with a Disruption of the Thrombospondin 3 Gene Differ in Geometric and Biomechanical Properties of Bone and Have Accelerated Development of the Femoral Head". Molecular and Cellular Biology. 25 (13): 5599–5606. doi:10.1128/MCB.25.13.5599-5606.2005. PMC   1156967 . PMID   15964815.
8. Niemi, Mari E. K.; et al. (July 2021). "Mapping the human genetic architecture of COVID-19". Nature. 600 (7889): 472–477. doi:10.1038/s41586-021-03767-x. PMC   8674144 . PMID   34237774. S2CID   235776838.

Further reading

• O'Rourke KM, Laherty CD, Dixit VM (1993). "Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers". J. Biol. Chem. 267 (35): 24921–4. doi: 10.1016/S0021-9258(19)73983-0 . PMID   1459996.
• Adolph KW, Long GL, Winfield S, et al. (1995). "Structure and organization of the human thrombospondin 3 gene (THBS3)". Genomics. 27 (2): 329–36. doi:10.1006/geno.1995.1050. PMID   7558000.
• Qabar A, Derick L, Lawler J, Dixit V (1995). "Thrombospondin 3 is a pentameric molecule held together by interchain disulfide linkage involving two cysteine residues". J. Biol. Chem. 270 (21): 12725–9. doi: 10.1074/jbc.270.21.12725 . PMID   7759526.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Qabar AN, Lin Z, Wolf FW, et al. (1994). "Thrombospondin 3 is a developmentally regulated heparin binding protein". J. Biol. Chem. 269 (2): 1262–9. doi: 10.1016/S0021-9258(17)42252-6 . PMID   8288588.
• Bornstein P, Devarayalu S, Edelhoff S, Disteche CM (1993). "Isolation and characterization of the mouse thrombospondin 3 (Thbs3) gene". Genomics. 15 (3): 607–13. doi:10.1006/geno.1993.1114. PMID   8468055.
• Winfield SL, Tayebi N, Martin BM, et al. (1997). "Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease". Genome Res. 7 (10): 1020–6. doi:10.1101/gr.7.10.1020. PMC   310674 . PMID   9331372.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Adolph KW (1999). "Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues". Biochem. Biophys. Res. Commun. 258 (3): 792–6. doi:10.1006/bbrc.1999.0710. PMID   10329465.
• Adolph KW, Bornstein P (2000). "The human thrombospondin 3 gene: analysis of transcription initiation and an alternatively spliced transcript". Mol. Cell Biol. Res. Commun. 2 (1): 47–52. doi:10.1006/mcbr.1999.0148. PMID   10527891.
• Carron JA, Hiscott P, Hagan S, et al. (2001). "Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4". Int. J. Biochem. Cell Biol. 32 (11–12): 1137–42. doi:10.1016/S1357-2725(00)00065-0. PMID   11137453.
• Armstrong DJ, Hiscott P, Batterbury M, Kaye S (2002). "Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype". Int. J. Biochem. Cell Biol. 34 (6): 588–93. doi:10.1016/S1357-2725(01)00157-1. PMID   11943589.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Dalla-Torre CA, Yoshimoto M, Lee CH, et al. (2006). "Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma". BMC Cancer. 6: 237. doi:10.1186/1471-2407-6-237. PMC   1609181 . PMID   17022822.