Thrombospondin 3

Last updated
THBS3
Identifiers
Aliases THBS3 , TSP3, thrombospondin 3
External IDs OMIM: 188062 MGI: 98739 HomoloGene: 5159 GeneCards: THBS3
Gene location (Human)
Ideogram human chromosome 1.svg
Chr. Chromosome 1 (human) [1]
Human chromosome 1 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 1q22Start155,195,588 bp [1]
End155,209,051 bp [1]
RNA expression pattern
PBB GE THBS3 209561 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252607
NM_001252608
NM_007112

NM_013691

RefSeq (protein)

NP_001239536
NP_001239537
NP_009043

NP_038719

Location (UCSC) Chr 1: 155.2 – 155.21 Mb Chr 3: 89.22 – 89.23 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Thrombospondin-3 (TSP3) is a protein that in humans is encoded by the THBS3 gene. [5] [6]

The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. TSP3 has been found to be involved in the regulation of skeletal maturation. [7] This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. [6]

Related Research Articles

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Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor.

Collagen, type V, alpha 1

Collagen alpha-1(V) chain is a protein that in humans is encoded by the COL5A1 gene.

MAP2K2

Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene. It is more commonly known as MEK2, but has many alternative names including CFC4, MKK2, MAPKK2 and PRKMK2.

PRKCH

Protein kinase C eta type is an enzyme that in humans is encoded by the PRKCH gene.

ADAMTS1

A disintegrin and metalloproteinase with thrombospondin motifs 1 is an enzyme that in humans is encoded by the ADAMTS1 gene.

ADAM9

Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene.

Thrombospondin-2

Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene.

EIF2S2

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.

Tropomodulin 1

Tropomodulin-1 is a protein that in humans is encoded by the TMOD1 gene.

Syntaxin binding protein 2

Syntaxin-binding protein 2 is a protein that in humans is encoded by the STXBP2 gene.

DYNC1I1

Cytoplasmic dynein 1 intermediate chain 1 is a protein that in humans is encoded by the DYNC1I1 gene.

Thrombospondin 4

Thrombospondin-4 is a protein that in humans is encoded by the THBS4 gene.

MAPKAPK5

MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5 gene. The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases, including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately-spliced transcript variants of this gene encoding distinct isoforms have been reported.

MYO18A

Myosin-XVIIIa is a protein that in humans is encoded by the MYO18A gene.

MTX1

Metaxin 1, also known as MTX1, is a protein which in humans is encoded by the MTX1 gene.

ADAMTS9

A disintegrin and metalloproteinase with thrombospondin motifs 9 is an enzyme that in humans is encoded by the ADAMTS9 gene.

DYNLT3

Dynein, light chain, Tctex-type 3, also known as DYNLT3, is a protein which in humans is encoded by the DYNLT3 gene.

ADAMTS10

A disintegrin and metalloproteinase with thrombospondin motifs 10 is an enzyme that in humans is encoded by the ADAMTS10 gene.

NELL2

Protein kinase C-binding protein NELL2 is an enzyme that in humans is encoded by the NELL2 gene.

Lamin B1

Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000169231 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028047 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Vos HL, Devarayalu S, de Vries Y, Bornstein P (Jul 1992). "Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family". J Biol Chem. 267 (17): 12192–6. PMID   1601886.
  6. 1 2 "Entrez Gene: THBS3 thrombospondin 3".
  7. Hankenson, Kurt (July 2005). "Mice with a Disruption of the Thrombospondin 3 Gene Differ in Geometric and Biomechanical Properties of Bone and Have Accelerated Development of the Femoral Head". Molecular and Cellular Biology. 25 (13): 5599–5606. doi:10.1128/MCB.25.13.5599-5606.2005. PMC   1156967 . PMID   15964815 . Retrieved 24 February 2015.

Further reading